Adverse reactions to bactrim® — a retrospective view

Hell, K

doi:10.1007/bf01643193

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The main reported ADRs were cutaneous disorders, hematological disorders, and kidney failure. They were consistent with those described in the existing literature [2,8,9]. A recent study showed a 20% incidence of hyperkalemia with cotrimoxazole antibiotic treatment, compared with 5% with ceftriaxone [10].…”

Section: Discussionsupporting

confidence: 91%

“…It has long been considered as a welltolerated antibiotic agent and was therefore used until the 1980s as a first-line treatment in a broad field of indications for acute and chronic infections [1]. This widespread use for decades has enabled to identify and precisely describe many cotrimoxazole-induced adverse drug reactions (ADRs), such as cutaneous, liver, blood, or kidney disorders, sometimes serious and even life-threatening [2,3]. Official recommendations have been progressively changed; indications have been restricted and contraindications, new precautions for use and special warnings including drug interactions have been mentioned in the Summary of Product Characteristics (SPC).…”

Section: Introductionmentioning

confidence: 99%

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Adverse drug reactions induced by cotrimoxazole: Still a lot of preventable harm

Coppry

Duret

Berdaï

et al. 2021

Fundamemntal Clinical Pharma

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Owing to a broad spectrum and low cost antimicrobial, cotrimoxazole is largely prescribed. However, its use is associated with various adverse drug reactions (ADRs) that warrant to ensure rational prescribing. This study aimed to describe spontaneous reports of cotrimoxazole ADRs and to evaluate the quality of prescription in patients who had ADRs. Suspected cotrimoxazole-induced ADRs cases reported to the Bordeaux regional pharmacovigilance center (France) during a 5-year period were described. Seriousness was assessed according to international criteria. Quality of prescription was assessed by compliance with the Summary of Product Characteristics (SPC) and relevance of cotrimoxazole indication. Then, an ADR was considered as preventable if the cotrimoxazole indication was not relevant, or potentially preventable if indication was relevant but the prescription was not compliant with the SPC. A total of 96 cases were analyzed: median age was 60.5 years (range: 4-94); 59.4% of patients were male. ADRs were mostly cutaneous disorders (n = 46) and hematological disorders (n = 25). A total of 60 serious ADRs occurred in 55 patients. Prescribers complied with all SPC recommendations in 21.9% of cases. Indication of cotrimoxazole was relevant or highly relevant in 41 cases. In 58% of cases, the occurrence of a cotrimoxazole-induced ADR would have been preventable or potentially preventable. In a context of increasing interest for this antibiotic to treat infections due to resistant bacteria, physicians should be more aware of the potential consequences of inappropriate prescribing cotrimoxazole and reserve its use when there is no alternative and under suitable monitoring.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Adverse drug reactions induced by cotrimoxazole: Still a lot of preventable harm

Coppry

Duret

Berdaï

et al. 2021

Fundamemntal Clinical Pharma

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“…TMP-SMX therapy-related toxicity is frequent. They often include myelosuppression, hepatoxicity, and renal insufficiency [24] . Not obtaining drug levels and choosing reduced versus conventional standard doses of TMP-SMX to cause less toxicity is not supported by any evidence.…”

Section: Discussionmentioning

confidence: 99%

Observational study of the clinical utility of sulfamethoxazole serum level monitoring in the treatment of brain abscesses due to Nocardia species

et al. 2022

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Although there is a lack of data in trimethoprim-sulfamethoxazole (TMP-SMX) serum monitoring utility for invasive nocardial infections, therapeutic drug monitoring is widely used to optimize dosing and avoid adverse reactions that may cause treatment interruption. We retrospectively reviewed all adults who received TMP-SMX to treat nocardial brain abscess and had SMX serum level testing from 2010 to 2020. Twenty-two patients received treatment with TMP-SMX for Nocardia species brain abscess and 16 (72.7%) had a reported SMX level, with a median patient age of 65.5 years (interquartile range, IQR 59.5–72.5). Compared to those who did not have a documented SMX serum level, patients with SMX levels had a shorter median course of TMP-SMX treatment (322 days [IQR 188–365] vs. 365 [IQR 224–365]; P = .31) and higher therapeutic induction dose (10 [62.5%] vs. 3 [50%]; P = .92). Similarly, they were more frequently on hemodialysis (3 [13.6%] vs. 1 [4.5%]; P = > .99). The median peak level was 158.5 (IQR 120–218) μg/mL, collected at 2 hours (75%) post-administration in the induction phase (81.3%). Patients with documented SMX levels had fewer reported drug toxicity (5 [31.3%] vs. 4 [66.7%]; P = .1) than those without SMX levels. Among the five patients who reported TMP-SMX-related toxicity, 4 (80%) had an SMX peak level >150 μg/mL. There was no difference in the cure, relapse, and death rates among the two groups. While SMX level was not associated with Nocardia species brain abscess cure rates and mortality, most patients with SMX peak >150 μg/mL experienced drug toxicity.

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Application of International Consensus Meeting Criteria for Classifying Drug-Induced Liver Disorders

Bussières

Habra

1995

Ann Pharmacother

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Adverse reactions to bactrim® — a retrospective view

Cited by 3 publications

References 9 publications

Adverse drug reactions induced by cotrimoxazole: Still a lot of preventable harm

Adverse drug reactions induced by cotrimoxazole: Still a lot of preventable harm

Observational study of the clinical utility of sulfamethoxazole serum level monitoring in the treatment of brain abscesses due to Nocardia species

Application of International Consensus Meeting Criteria for Classifying Drug-Induced Liver Disorders

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