Adverse reactions to fluorescein angiography: A comprehensive review of the literature

Kornblau, Ilyse; El-Annan, Jaafar

doi:10.1016/j.survophthal.2019.02.004

Cited by 94 publications

(54 citation statements)

References 75 publications

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“…FA, an invasive method that uses fluorescent dye to visualize retinal vasculature in vivo, is currently the gold standard to evaluate the leakage of MAs. The side effects of the contrast agents, including lightheadedness, nausea and vomiting, as well as rarer instances of allergy and even anaphylaxis, nevertheless limit its application in some DR patients [14,15]. OCT, on the other hand, can capture some, but not all MAs and it also does not address the perfusion status.…”

Section: Introductionmentioning

confidence: 99%

Predictive modelling of thrombus formation in diabetic retinal microaneurysms

Sampani

Zheng

et al. 2020

R. Soc. open sci.

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Microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy (DR). Vision can be reduced at any stage of DR by MAs, which may enlarge, rupture and leak fluid into the neural retina. Recent advances in ophthalmic imaging techniques enable reconstruction of the geometries of MAs and quantification of the corresponding haemodynamic metrics, such as shear rate and wall shear stress, but there is lack of computational models that can predict thrombus formation in individual MAs. In this study, we couple a particle model to a continuum model to simulate the platelet aggregation in MAs with different shapes. Our simulation results show that under a physiologically relevant blood flow rate, thrombosis is more pronounced in saccular-shaped MAs than fusiform-shaped MAs, in agreement with recent clinical findings. Our model predictions of the size and shape of the thrombi in MAs are consistent with experimental observations, suggesting that our model is capable of predicting the formation of thrombus for newly detected MAs. This is the first quantitative study of thrombosis in MAs through simulating platelet aggregation, and our results suggest that computational models can be used to predict initiation and development of intraluminal thrombus in MAs as well as provide insights into their role in the pathophysiology of DR.

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Section: Introductionmentioning

confidence: 99%

Predictive modelling of thrombus formation in diabetic retinal microaneurysms

Sampani

Zheng

et al. 2020

R. Soc. open sci.

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“…Fluorescein angiography nevertheless presents several important shortcomings. The first is a contraindication to perform fluorescein angiography for patients with severe cardiac disease, severe cerebrovascular disease, severe diabetes, and liver cirrhosis [22][23][24]. Moreover, it is impossible to obtain contrast agents for pregnant women [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it is impossible to obtain contrast agents for pregnant women [25,26]. The second shortcoming is the risk of side effects presented by fluorescein angiography, such as anaphylaxis (difficulty of breathing and loss of consciousness) and cardiac arrest [24,27,28]. For this study, the proposed model enables the classification of CNV, DME, drusen, and normal with high accuracy using OCT images alone.…”

Section: Discussionmentioning

confidence: 99%

Classification of optical coherence tomography images using a capsule network

et al. 2020

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Background: Classification of optical coherence tomography (OCT) images can be achieved with high accuracy using classical convolution neural networks (CNN), a commonly used deep learning network for computer-aided diagnosis. Classical CNN has often been criticized for suppressing positional relations in a pooling layer. Therefore, because capsule networks can learn positional information from images, we attempted application of a capsule network to OCT images to overcome that shortcoming. This study is our attempt to improve classification accuracy by replacing CNN with a capsule network. Methods: From an OCT dataset, we produced a training dataset of 83,484 images and a test dataset of 1000 images. For training, the dataset comprises 37,205 images with choroidal neovascularization (CNV), 11,348 with diabetic macular edema (DME), 8616 with drusen, and 26,315 normal images. The test dataset has 250 images from each category. The proposed model was constructed based on a capsule network for improving classification accuracy. It was trained using the training dataset. Subsequently, the test dataset was used to evaluate the trained model.Results: Classification of OCT images using our method achieved accuracy of 99.6%, which is 3.2 percentage points higher than that of other methods described in the literature. Conclusion: The proposed method achieved classification accuracy results equivalent to those reported for other methods for CNV, DME, drusen, and normal images.

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“…69 The role of antihistamine and corticosteroid premedication for dyes is still being debated: The efficacy of premedication for fluorescein is unknown and is actively being discussed. 32,70 For patent blue and isosulfan blue, premedication with corticosteroids is thought to reduce severity of reaction, but not the occurrence of IHR. 4…”

Section: Management Of Patients With Previous Hypersensitivity To Dyesmentioning

confidence: 99%

Adverse reactions during procedures

Schönmann

Brockow

2020

Annals of Allergy, Asthma & Immunology

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Incidences of hypersensitivity reactions to contrast media and dyes are low, but because of their frequent use, the absolute number of hypersensitivity reactions is relevant and represents a clinical problem in allergology. Hypersensitivity reactions can be divided into 2 groups: immediate hypersensitivity (urticaria/angioedema/anaphylaxis) and nonimmediate hypersensitivity reactions (exanthems). Allergological workup (skin tests AE laboratory tests) is helpful to confirm an allergic mechanism and in those in whom the culprit is positive also to select skin test-negative alternatives for future procedures. For patients needing urgent re-administration without the possibility of allergological workup, the decision on avoidance of contrast media or readministration of one other than the culprit agent with premedication and emergency preparedness is based on the severity of the initial reaction. Provocation tests in an allergy department under emergency preparedness may be considered to confirm tolerance to an alternative contrast medium for readministration.

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Adverse reactions to fluorescein angiography: A comprehensive review of the literature

Cited by 94 publications

References 75 publications

Predictive modelling of thrombus formation in diabetic retinal microaneurysms

Predictive modelling of thrombus formation in diabetic retinal microaneurysms

Classification of optical coherence tomography images using a capsule network

Adverse reactions during procedures

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