Adverse reactions to food*

Bruijnzeel-Koomen, Carla A.F.M.; Ortolani, Claudio; K, Aas; Bindslev‐Jensen, Carsten; Björkstén, Bengt; Moneret‐Vautrin, D.A.; Wüthrich, B

doi:10.1111/j.1398-9995.1995.tb02579.x

Cited by 492 publications

(192 citation statements)

References 59 publications

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“…Adverse reactions to food may be classi®ed as non-immune mediated food intolerance or immune mediated food hypersensitivity (Bruijnzeel-Koomen et al, 1995). Adverse reactions to milk include lactose intolerance caused by lactase (b-galactosidase) de®ciency and milk hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…Transferred antigens stimulate the production of speci®c antibodies which is, however, strictly controlled in healthy subjects (Challacombe & Tomasi, 1980). Appearance of IgE is known to correlate with hypersensitivity reactions but the clinical relevance of IgG, IgA and IgM isotypes produced in response to dietary antigens is obscure (Bruijnzeel-Koomen et al, 1995). Most recently published papers suggest that IgG and IgA may have a role in hypersensitivity reactions (Keller et al, 1996;Marinkovich, 1996;Wutrich, 1996;Awazuhara et al, 1997;Duchen et al, 1997;Kolopp-Sarda et al, 1997;Shimojo et al, 1997;Spuergin et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Milk hypersensitivity in young adults

et al. 1999

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Objective: To estimate the prevalence of milk hypersensitivity in Finnish adults. Design: Cross-sectional study. Subjects: Two hundred men and 206 women aged 27 y randomly recruited from the population register in southwestern Finland. Interventions: The subjects were interviewed about their dairy product consumption, abdominal discomfort after dairy product intake and lactose intolerance. From serum samples, serum reactivity to milk protein and milk-speci®c IgG 1 , IgG 2 , IgG 3 and IgA were measured. Results: About 20% of the subjects reported abdominal discomfort after dairy product intake, whereas only 6.4% had been diagnosed to have lactose intolerance. The amount of milk consumed correlated well with the serum assay results in subjects reporting abdominal discomfort but not in subjects who were free from these symptoms. Among subjects with no record of dairy product restriction or lactose intolerance, those experiencing abdominal discomfort after dairy product intake had signi®cantly higher serum reactivity to milk protein than those without such discomfort. The concentrations of serum milk-speci®c antibodies did not differ between these two groups. The prevalence of milk hypersensitivity in this population was estimated to be 3 ± 6%. Conclusions: Milk hypersensitivity may be as common in adults as in infants. The measurement of serum reactivity to milk protein may prove useful in screening milk hypersensitivity in subjects who have not restricted their dairy product consumption.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Milk hypersensitivity in young adults

et al. 1999

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“…Protein specific IgE-mediated allergic reactions are known to be major in food allergy (17). In recent years, new proteins have been artificially produced in special foods, such as genetically modified foods (18).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Specific Degranulation of Mast Cell Sensitized by Several Allergens in Vitro

Guo

Lin

et al. 2009

Cell Mol Immunol

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Food allergy is a major health issue worldwide. Mast cells play a very important role in the immediate hypersensitivity for which mast cell degranulation needs to be studied extensively. In this study, an approach was taken to study the characteristics of sensitized mast cell degranulation in vitro, which associated with the study of mast cells and animal models. BALB/c mice were immunized respectively by several food allergens, then blood and peritoneal mast cells were collected at different time points. A dynamic determination was carried out between mast cells and serumal IgE. Comparative analysis on sequential time points showed that there was a close coincidence between mast cell degranulation and IgE antibody titers in sensitized BALB/c mice. Furthermore, it is interesting that sensitized mast cells could implement specific degranulation against the challenges in vitro, but the closely tropomyosins induced mast cell degranulation displayed cross reactions. This is very similar to IgE resisting the allergens in vivo. The study disclosed some characteristics on mast cells, coming from sensitized BALB/c mice, degranulation in vitro. Cellular & Molecular Immunology. 2009;6(2):149-153.

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“…Duodenal histology was normal in patients with urticaria and showed mild aspeci®c in¯ammation in the other four subjects; no villous atrophy or eosinophilic in®ltration was detected. Diagnostic procedures, and especially DBPCFC, followed those recommended by the European Academy of Allergology (Bruijnzeel-Koomen et al, 1995). For DBPCFC, the amount of food that elicited symptoms in the blinded tests was the same as in previously performed open studies.…”

Section: A Pilot Studymentioning

confidence: 99%

Heretical thoughts about food hypersensitivity: small bowel manometry as an objective way to document gut reactions

1997

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Background: Food hypersensitivity is a frequent complaint by both pediatric and adult subjects. However, notwithstanding patient' belief about`allergies' related to food stuffs, only a minority of them have actually such a diagnosis substantiated. Moreover, the diagnostic approach to these problems is cumbersome and unsatisfactory, and the objectivation of a food hypersensitivity is often dif®cult. Patients and methods: For these reasons we studied by means of small bowel manometry a small group of patients with food hypersensitivity, and showed abnormal fasting and postprandial ®ndings in those with the gut as a target organ on clinical grounds. Results: Manometric abnormalities were somewhat similar to those previously described in celiac disease, a well recognized food allergy disease. The possible usefulness of this technique in the investigative approach of food hypersensitivity is discussed.

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Adverse reactions to food*

Cited by 492 publications

References 59 publications

Milk hypersensitivity in young adults

Milk hypersensitivity in young adults

Studies on the Specific Degranulation of Mast Cell Sensitized by Several Allergens in Vitro

Heretical thoughts about food hypersensitivity: small bowel manometry as an objective way to document gut reactions

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