Adverse Reactions to Tetracycline, Penicillin and an Oleandomycin-Penicillin Mixture Used in the Long-Term Therapy of Chronic Pulmonary Disease

Sobel, Stuart; Lichter, Edward A.; Davis, J.; Dowling, Harry F.; Lepper, Mark H.; Jackson, G. G.

doi:10.1097/00000441-196203000-00009

Cited by 7 publications

(2 citation statements)

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“…Tolerance of long-term oral antibiotics is a clear factor that may affect compliance and was recognised early on in antibiotic studies. 54 Aerosolised antibiotics began to be formally studied as potential means of delivering long-term antibacterial therapy to the diseased airways in the 1980s. With direct delivery to the lungs, systemic absorption could be anticipated to be minimal, with a lower risk of adverse systemic effects.…”

Section: Oral Antibioticsmentioning

confidence: 99%

CME: Non-cystic fibrosis bronchiectasis

2011

J R Coll Physicians Edinb

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Bronchiectasis is a chronic debilitating condition. Pathologically, a vicious cycle of infection and inflammation exists in the permanently damaged airways with patients suffering a persistent cough, chronic daily sputum production and recurrent chest infections. Once termed an 'orphan disease', the prevalence of bronchiectasis has become increasingly recognised over the past few decades. The associated burden of disease in terms of respiratory morbidity, effect on patients' healthrelated quality of life and the economic cost of long term management is significant and it has become apparent that more research into its causes and management is urgently needed. This article reviews what is currently known about bronchiectasis, its pathophysiology, aetiology and management strategies.

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Section: Oral Antibioticsmentioning

confidence: 99%

CME: Non-cystic fibrosis bronchiectasis

2011

J R Coll Physicians Edinb

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“…In a recent review of the adverse reactions observed by our group, Sobel and coauthors 25 reported that upper gastrointestinal symptoms were more frequent in patients receiving penicillin or a penicillinoleadomycin mixture, while diarrhea was more common in patients receiving tetracycline. During 36 months of observation, a skin rash was seen once in conjunction with tetracycline therapy and once in a patient receiving oleandomycin and penicillin.…”

Section: Adverse Reactions To Antibioticsmentioning

confidence: 98%