Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study

Abiad, Hala Feghali; Alameddine, Valeria Modica; Hallit, Souheil; Torbey, Paul-Henry; Mroueh, Salman; Yazbek, Nelly; Asmar, Edgard; Hage, Pierre; Fares, George Abi; Samarani, Marie; Khalife, Marie-Claude Fadous

doi:10.1007/s11356-019-07234-z

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…Additionally, school-age asthma accounted for 40.6% of the sample and 48.5% of the children taking SPT. Although there was no difference in the percentages of sensitizations to specific aeroallergens, the percentage of overall aeroallergen sensitization was higher in school-age children than in younger ones (93.8% vs 72.1%, p=0.001), which is similar to previous studies ( 16 , 18 ). It may be related to dynamic of IgE levels by age.…”

Section: Discussionsupporting

confidence: 90%

Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations

Thao,

Kien,

Tuan

et al. 2023

Med Arch

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Background: Allergic asthma represents the most popular phenotype of childhood asthma and is characterized by eosinophilic airway inflammation associated with specific immunoglobulin E (IgE) antibodies sensitization to various allergens, as evidenced by serology or skin prick test.2 Sensitization to indoor aeroallergens is associated with severe asthma and severe asthma exacerbations. Objective: This study aimed to identify the prevalence of aeroallergen sensitization and its associated factors in children with an asthma exacerbation in Vietnam. Methods: A cross-sectional study was conducted at Children’s Hospital 1, Ho Chi Minh City (HCMC). Children who were aged 3 to 15 and admitted to the hospital with moderate or severe asthma exacerbation were recruited to the study. Data was collected from interviews and medical records. SPT was used to identify aeroallergen sensitization. The association between school-age, living area, and passive smoking with the odds of aeroallergen sensitization was assessed using a multivariable logistic regression. Results: The prevalence of aeroallergen sensitization was 82.6% and this figure in school-age children was higher than that in preschool-age ones (93.8% vs 72.1%, p=0.001). School-age, living in HCMC, and passive smoking significantly increased the odds of aeroallergen sensitization in asthmatic children with adjusted OR [95%CI] as 6.9 [2.1-23.3], 4.1 [1.5-11.5], and 2.9 [1.0-8.4], respectively. Asthmatic children with aeroallergen sensitization required more hours to resolve an asthma exacerbation than those without (22.4 vs 15.2, p=0.006). Conclusion: Aeroallergen sensitization was common in hospitalized children with moderate or severe asthma exacerbation. It is necessary to establish environmental policy and screening practices of aeroallergen sensitization to improve the quality of asthma management for Vietnamese children.

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Section: Discussionsupporting

confidence: 90%

Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations

Thao,

Kien,

Tuan

et al. 2023

Med Arch

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“…Compared with a recent national cross‐sectional study conducted from 2008 to 2018, HDMs were still the most popular aeroallergens in China 16 . In our study, HDMs and pollens sensitization was observed in nearly half of the cases of AA patients in the eastern and western regions, respectively, consistent with Lebanese asthmatic patients 17 . Similarly, relevant results were observed in Southeast Asia and Asia areas, reporting a high sensitization rate to HDMs in the Philippines (97.4%), 18 Singapore (68.5%), 19 Thailand (65.0%), 20 and South Korea (21.4%) 21 .…”

Section: Discussionsupporting

confidence: 61%

“… 16 In our study, HDMs and pollens sensitization was observed in nearly half of the cases of AA patients in the eastern and western regions, respectively, consistent with Lebanese asthmatic patients. 17 Similarly, relevant results were observed in Southeast Asia and Asia areas, reporting a high sensitization rate to HDMs in the Philippines (97.4%), 18 Singapore (68.5%), 19 Thailand (65.0%), 20 and South Korea (21.4%). 21 Moreover, in comparison with the former study (13.38%), 22 a slight increase in the sensitization rate of HDMs (20.0%) in western regions, indicating that more importance should be attached to co‐sensitization to mites when doctors diagnose allergy patients in western areas.…”

Section: Discussionmentioning

confidence: 68%

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Zhang,

Luo,

et al. 2023

Clinical & Translational All

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Background: This cross-sectional study aimed to identify latent sensitization profiles of asthma patients in mainland China, unveiling the association between regional differences and sensitization patterns.Methods: 1056 asthma participants from 10 medical centers divided into eastern and western cohorts were clustered into four individual sensitization patterns, respectively, by using an unsupervised statistical modeling method, latent class analysis (LCA), based on the levels of 12 aeroallergens specific IgE reactivities.

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“…Since asthmaassociated allergic sensitization represented about 80% and 90% of the cases. 18,19 In our study, it might be that subjects who underwent an rtRT-PCR-SARS-CoV-2 test could be mainly those with non-atopic asthma.…”

Section: Discussionmentioning

confidence: 84%

Low prevalence of asthma in Mexican children and adults with a positive rtRT-PCR test for SARS-CoV-2: a cross-sectional study during the 2020 pandemic

Bedolla-Barajas

Morales-Romero

Bedolla-Pulido

et al. 2021

aei

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Background: It has recently been argued that asthma does not increase the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. If so, the prevalence of asthma in subjects diagnosed with COVID-19 should be lower than in the general population. Objective: To determine the prevalence of asthma in Mexican children and adults with SARS-CoV-2 infection.Methods: A public database of the Epidemiological Surveillance System for Viral Respiratory Disease in Mexico was analyzed. Those who underwent the real-time reverse transcriptase-polymerase chain reaction-SARS-CoV-2 (rtRT-PCR-SARS-CoV-2) test from February 27 to June 21, 2020, were included. In addition to the prevalence of asthma, some factors associated with it were investigated. Results: Data from 417,366 subjects were analyzed. Asthma prevalence in children, adults, and global were 3.7%, 3.3%, and 3.3%, respectively. Although the asthma prevalence was lower in SARS-CoV-2 positive over negative patients, significant differences were only found in adults (2.8% vs. 3.7% respectively; odds ratio (OR) = 0.74; 95% confidence interval (CI): 0.71–0.77); but not in children (3.5% vs. 3.8%, respectively; OR = 0.91; 95%CI: 0.76–1.10). Multivariate analysis showed in younger than 18 years that girls and immunosuppression were factors associated with a decrease in the odds to develop asthma. In adults, asthma was positively associated with females, obesity, smoking, immunosuppression, chronic obstructive pulmonary disease, arterial hypertension, and cardiovascular disease.

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Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study

Cited by 9 publications

References 25 publications

Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations

Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Low prevalence of asthma in Mexican children and adults with a positive rtRT-PCR test for SARS-CoV-2: a cross-sectional study during the 2020 pandemic

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