Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Kim, Doo Young; Kim, Jae-Hyung; Park, Si-Woon

doi:10.1111/ecc.13050

Cited by 10 publications

(5 citation statements)

References 40 publications

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“…If a decrease in muscle force is classically observed in patients with breast cancer post‐CT, 36,37 we demonstrated that the reduction in knee extensor muscle force occurred within the first 8 weeks of treatment, emphasizing early skeletal muscle deconditioning. With no reduction in leg skeletal muscle mass during CT, the reduction in muscle force is likely explained by neural alterations 26 .…”

Section: Discussionmentioning

confidence: 64%

Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Mallard

Hucteau

Schött

et al. 2022

Cancer

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Background Fatigue is a hallmark of breast cancer and is associated with skeletal muscle deconditioning. If cancer‐related fatigue occurs early during chemotherapy (CT), the development of skeletal muscle deconditioning and its effect on exercise capacity remain unclear. The aim of this study was to investigate the evolution of skeletal muscle deconditioning and exercise capacity in patients with early‐stage breast cancer during CT. Methods Patients with breast cancer had a visit before undergoing CT, at 8 weeks, and at the end of chemotherapy (post‐CT). Body composition was determined through bioelectrical impedance analysis. Knee extensor, handgrip muscle force and fatigue was quantified by performing maximal voluntary isometric contractions and exercise capacity using the 6‐min walking test. Questionnaires were also administered to evaluate quality of life, cancer‐related fatigue, and physical activity level. Results Among the 100 patients, reductions were found in muscle mass (−2.3%, p = .002), exercise capacity (−6.7%, p < .001), and knee extensor force (−4.9%, p < .001) post‐CT, which occurred within the first 8 weeks of treatment with no further decrease thereafter. If muscle fatigue did not change, handgrip muscle force decreased post‐CT only (−2.5%, p = .001), and exercise capacity continued to decrease between 8 weeks and post‐CT (−4.6%, p < .001). Quality of life and cancer‐related fatigue were impaired after 8 weeks (p < .001) and remained stable thereafter, whereas the physical activity level remained stable during chemotherapy. Conclusions Similar to cancer‐related fatigue, skeletal muscle deconditioning and reduced exercise capacity occurred early during breast cancer CT. Thus, it appears essential to prevent these alterations through exercise training implemented during CT.

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Section: Discussionmentioning

confidence: 64%

Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Mallard

Hucteau

Schött

et al. 2022

Cancer

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“…Aerobic exercise promotes the ability to perform moderate to vigorous ET within the abilities of the respiratory, cardiovascular, and muscular systems to integrate physiological and functional states for a prolonged period of time [ 121 ], which can be accessed via aerobic capacity [ 122 ]. A poor aerobic capacity has been associated with a markedly increased risk of premature death [ 123 ] and the development of several non-communicable diseases [ 124 ], including cancer [ 125 ].…”

Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Rocha-Rodrigues

Matos

Afonso

et al. 2021

IJMS

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Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.

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“…Cardiorespiratory fitness (CRF) improves physical and cognitive function and is associated with a lower risk of cardiovascular disease, 1 diabetes, and cancer 2 ; fewer postsurgical complications 3 ; and improved health-related quality of life. 4 , 5 An expanding body of evidence suggests that CRF can be increased preoperatively, improving postoperative outcomes. 3 , 6 , 7 Surgical recovery increases postoperative oxygen consumption by up to 50% 8 , 9 in response to inflammation and to promote tissue healing.…”

Section: Introductionmentioning

confidence: 99%

Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major Surgery

et al. 2023

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ImportancePreoperative high-intensity interval training (HIIT) is associated with improved cardiorespiratory fitness (CRF) and may improve surgical outcomes.ObjectiveTo summarize data from studies comparing the association of preoperative HIIT vs standard hospital care with preoperative CRF and postoperative outcomes.Data SourcesData sources included Medline, Embase, Cochrane Central Register of Controlled Trials Library, and Scopus databases with no language constraints, including abstracts and articles published before May 2023.Study SelectionThe databases were searched for randomized clinical trials and prospective cohort studies with HIIT protocols in adult patients undergoing major surgery. Thirty-four of 589 screened studies met initial selection criteria.Data Extraction and SynthesisA meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Data were extracted by multiple independent observers and pooled in a random-effects model.Main Outcomes and MeasuresThe primary outcome was change in CRF, as measured by either peak oxygen consumption (V̇o2 peak) or 6-Minute Walk Test (6MWT) distance. Secondary outcomes included postoperative complications; hospital length of stay (LOS); and changes in quality of life, anaerobic threshold, and peak power output.ResultsTwelve eligible studies including 832 patients were identified. Pooled results indicated several positive associations for HIIT when compared with standard care either on CRF (V̇o2 peak, 6MWT, anaerobic threshold, or peak power output) or postoperative outcomes (complications, LOS, quality of life), although there was significant heterogeneity in study results. In 8 studies including 627 patients, there was moderate-quality evidence of significant improvement in V̇o2 peak (cumulative mean difference, 2.59 mL/kg/min; 95% CI, 1.52-3.65 mL/kg/min; P &lt; .001). In 8 studies including 770 patients, there was moderate-quality evidence of a significant reduction in complications (odds ratio, 0.44; 95% CI, 0.32-0.60; P &lt; .001). There was no evidence that HIIT differed from standard care in hospital LOS (cumulative mean difference, −3.06 days; 95% CI, −6.41 to 0.29 days; P = .07). The analysis showed a high degree of heterogeneity in study outcomes and an overall low risk of bias.Conclusions and RelevanceThe results of this meta-analysis suggest that preoperative HIIT may be beneficial for surgical populations through the improvement of exercise capacity and reduced postoperative complications. These findings support including HIIT in prehabilitation programs before major surgery. The high degree of heterogeneity in both exercise protocols and study results supports the need for further prospective, well-designed studies.

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Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Cited by 10 publications

References 40 publications

Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major Surgery

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