Aerobic exercise abolishes cTBS-induced suppression of motor cortical excitability

Singh, Amaya M.; Duncan, Robin E.; Staines, Richard

doi:10.1016/j.neulet.2016.09.027

Cited by 17 publications

(12 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that, after the GXT, CSE in the affected side did not increase more significantly could be simply due to a reduction of the neuroplastic potential after stroke. 59 Indeed, in young individuals without disability, 18,55 one bout of exercise has shown to reduce the suppressing effects of cTBS on CSE. In contrast, in individuals with chronic stroke, one bout of exercise does not amplify the facilitatory effects that intermittent TBS has shown to have on CSE, 24 suggesting that after stroke, neuroplasticity is less responsive to change with exercise.…”

Section: Discussionmentioning

confidence: 99%

A Single Bout of High-Intensity Interval Training Improves Motor Skill Retention in Individuals With Stroke

Nepveu

Thiel

Tang

et al. 2017

Neurorehabil Neural Repair

153

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

A Single Bout of High-Intensity Interval Training Improves Motor Skill Retention in Individuals With Stroke

Nepveu

Thiel

Tang

et al. 2017

Neurorehabil Neural Repair

153

View full text Add to dashboard Cite

show abstract

“…Due to various interacting and dynamically changing parameters, caution must be given to those moderating parameters that could significantly impact the interaction between both techniques, possibly leading to the abolishment of any effect (see Singh et al, 2016). As outlined, moderating parameters of AE and tDCS, such as exercise and electric intensity, tDCS polarity, exercise and tDCS duration, and timing of tDCS, provoke modifications on several levels of the human organism, even with only one application.…”

Section: Discussionmentioning

confidence: 99%

A Review of Acute Aerobic Exercise and Transcranial Direct Current Stimulation Effects on Cognitive Functions and Their Potential Synergies

Steinberg

Pixa

Fregni

2019

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Today, several pharmaceutic and non-pharmaceutic approaches exist to treat psychiatric and neurological diseases. Because of the lack of treatment procedures that are medication free and without severe side effects, transcranial direct current stimulation (tDCS) and aerobic exercise (AE) have been tested to explore the potential for initiating and modulating neuroplasticity in the human brain. Both tDCS and AE could support cognition and behavior in the clinical and non-clinical context to improve the recovery process within neurological or psychiatric conditions or to increase performance. As these techniques still lack meaningful effects, although they provide multiple beneficial opportunities within disease and health applications, there is emerging interest to find improved tDCS and AE protocols. Since multimodal approaches could provoke synergetic effects, a few recent studies have begun to combine tDCS and AE within different settings such as in cognitive training in health or for treatment purposes within clinical settings, all of which show superior effects compared to single technique applications. The beneficial outcomes of both techniques depend on several parameters and the understanding of neural mechanisms that are not yet fully understood. Recent studies have begun to directly combine tDCS and AE within one session, although their interactions on the behavioral, neurophysiological and neurochemical levels are entirely unclear. Therefore, this review: (a) provides an overview of acute behavioral, neurophysiological, and neurochemical effects that both techniques provoke within only one single application in isolation; (b) gives an overview regarding the mechanistic pathways; and (c) discusses potential interactions and synergies between tDCS and AE that might be provoked when directly combining both techniques. From this literature review focusing primarily on the cognitive domain in term of specific executive functions (EFs; inhibition, updating, and switching), it is concluded that a direct combination of tDCS and AE provides multiple beneficial opportunities for synergistic effects. A combination could be useful within non-clinical settings in health and for treating several psychiatric and neurologic conditions. However, there is a lack of research and there are several possibly interacting moderating parameters that must be considered and more importantly must be systematically investigated in the future.

show abstract

“…via increased cerebral blood flow and upregulated BDNF), whereas engaging in exercise following rTMS may have a consolidating effect, maintaining an environment conducive to neuroplasticity (Hendrikse et al, 2017). Indeed, there is some evidence that performing exercise prior to (McDonnell et al, 2013), or following (Singh, Duncan, & Staines, 2016) a single dose of cTBS, has different effects on cortical excitability. Further, a bout of exercise performed four hours after learning increases memory retention (van Dongen, Kersten, Wagner, Morris, & Fernández, 2016), indirectly supporting the notion that exercise enhances consolidation of altered cortical dynamics.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

The effects of multi-day rTMS and cardiorespiratory fitness on working memory and local GABA concentration

Hendrikse

Thompson

Suo

et al. 2020

Preprint

View full text Add to dashboard Cite

Working memory (WM) refers to the capacity to temporarily retain and manipulate finite amounts of information; a critical process in complex behaviours such as reasoning, comprehension, and learning. This cognitive function is supported by a parietal-prefrontal network and linked to the activity of key brain neurotransmitters, such as gamma-aminobutyric acid (GABA). Impairments in WM are seen in a range of psychiatric and neurological disorders, and there are currently no effective methods of remediating WM deficits. In this study, we analysed secondary outcome measures from a trial investigating the effects of multi-day rTMS on cognition. Participants received four days of 20 Hz rTMS to an individualised region of left parietal cortex in one week, and an individualised region of pre-supplementary motor area (pre-SMA) in a separate week. We assessed changes to WM function before and after each week of stimulation (N = 39), and changes to GABA concentration before and after stimulation in week one using MR spectroscopy (N = 18 per stimulation condition). We hypothesised that multi-day parietal rTMS would enhance WM and reduce GABA concentration, but this was not observed. Instead, we report some evidence of improved WM function and increased GABA concentration following pre-SMA rTMS, although this effect was variable across individuals. Additionally, we found that higher cardiorespiratory fitness was associated with greater WM improvement following pre-SMA stimulation. While there are a number of factors known to influence the response to rTMS, increasing cardiorespiratory fitness may provide a novel approach to enhance cognitive outcomes. Given the clinical utility of both exercise and rTMS, future studies are required to determine whether additive effects may be achieved when applied in tandem.

show abstract

Aerobic exercise abolishes cTBS-induced suppression of motor cortical excitability

Cited by 17 publications

References 44 publications

A Single Bout of High-Intensity Interval Training Improves Motor Skill Retention in Individuals With Stroke

A Single Bout of High-Intensity Interval Training Improves Motor Skill Retention in Individuals With Stroke

A Review of Acute Aerobic Exercise and Transcranial Direct Current Stimulation Effects on Cognitive Functions and Their Potential Synergies

The effects of multi-day rTMS and cardiorespiratory fitness on working memory and local GABA concentration

Contact Info

Product

Resources

About