Aerobic exercise and dual-task training combination is the best combination for improving cognitive status, mobility and physical performance in older adults with mild cognitive impairment

UYSAL, İsmail; Başar, Selda; Aysel, Süleyman; Kalafat, Devrim; Büyüksünnetçi, Ali Önder

doi:10.1007/s40520-022-02321-7

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…Concerning quality of life measures, comparable beneficial effects were recorded following both training regimens. In line with this, the trial results of Uysal et al [57] proved that aerobic exercise and dual-task training are the best combination for improving cognitive status, mood, and quality of life in older adults with MCI.…”

Section: Discussionmentioning

confidence: 70%

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Ayed,

Aouichaoui,

Ammar

et al. 2024

EJIHPE

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Background: This study investigated whether combining simultaneous physical and cognitive training yields superior cognitive outcomes compared with aerobic training alone in individuals with mild cognitive impairment (MCI) and whether these benefits persist after four weeks of detraining. Methods: Forty-four people with MCI (11 males and 33 females) aged 65 to 75 years were randomly assigned to an 8-week, twice-weekly program of either aerobic training (AT group, n = 15), aerobic training combined with cognitive games (ACT group, n = 15), or simply reading for controls (CG group, n = 14). Selective attention (Stroop), problem-solving (Hanoi Tower), and working memory (Digit Span) tasks were used to assess cognitive performances at baseline, in the 4th (W4) and 8th weeks (W8) of training, and after 4 weeks of rest (W12). Results: Both training interventions induced beneficial effects on all tested cognitive performance at W4 (except for the number of moves in the Hanoi tower task) and W8 (all p <0.001), with the ACT group exhibiting a more pronounced positive impact than the AT group (p < 0.05). This advantage was specifically observed at W8 in tasks such as the Stroop and Tower of Hanoi (% gain ≈40% vs. ≈30% for ACT and AT, respectively) and the digit span test (% gain ≈13% vs. ≈10% for ACT and AT, respectively). These cognitive improvements in both groups, with the greater ones in ACT, persisted even after four weeks of detraining, as evidenced by the absence of a significant difference between W8 and W12 (p > 0.05). Concerning neuropsychological assessments, comparable beneficial effects were recorded following both training regimens (all p < 0.05 from pre- to post-intervention). The control group did not show any significant improvement in most of the cognitive tasks. Conclusions: The greater mid-term and long-lasting effects of combined simultaneous physical–cognitive training underscores its potential as a cost-effective intervention for the prevention and management of cognitive decline. While these results are valuable in guiding optimal physical and mental activity recommendations for adults with MCI, further neurophysiological-based studies are essential to offer robust support and deepen our understanding of the mechanisms underlying these promising findings.

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Section: Discussionmentioning

confidence: 70%

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Ayed,

Aouichaoui,

Ammar

et al. 2024

EJIHPE

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“…In coproduction of a multimodal intervention for people with mild memory concerns, a focus on addressing mental wellbeing and support to meet personalised goals emerged (Cooper et al, 2021). Such approaches were evaluated in lower quality multimodal studies and showed some promise (Uysal et al, 2023; Young et al, 2017). While almost all included trials reported a cognitive primary outcome, other outcomes, such as personalised goal attainment have been used in dementia non-pharmacological trials, as they can be more sensitive to, and perhaps more possible to change (Cooper et al, 2024).…”

Section: Discussionmentioning

confidence: 99%

“…Quantitative analysis was performed with R version 4.2.2 using R Studio (Posit team, 2023), and the packages readxl and metafor. For studies that included more than one intervention group, we included the comparison with the control group that demonstrated the greatest positive effect, which in both cases was the more intensive intervention (Lam et al, 2015; Uysal et al, 2023).…”

Section: Methodsmentioning

confidence: 99%

“…We were able to include 5/9 of these studies in our meta-analysis, of which only two were associated with outcomes favouring the intervention. These evaluated individual, thrice weekly balance, cardio, strength and cognitively challenging activities facilitated by a physiotherapist with experience (Uysal et al, 2023) and a holistic, multicomponent health intervention group, involving strategies to manage cognitive loss and promotion of healthy lifestyle, led by a social worker that had worked for two years with neurocognitive conditions (Young et al, 2017). Three of the studies included in metanalysis did not find significant results (Yu et al, 2019;Lam et al, 2015;Law et al, 2019; See Table 2/Figure 4).…”

Section: Studies Rated As Lower Quality (N=9)mentioning

confidence: 99%

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Lifestyle interventions for dementia prevention in Low- and Middle-Income Countries: A systematic review

Espinoza Jeraldo,

Zabihi,

Miranda-Castillo

et al. 2024

Preprint

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By 2050, two-thirds of people with dementia will live in Low- and Middle-Income Countries (LMICs). Efforts to adapt and test multi-modal prevention interventions focusing on lifestyle changes for people at risk of dementia are being developed predominantly in higher income countries, for people with and without cognitive symptoms. However, there is evidence that needs may differ between these groups. We systematically reviewed Randomized Controlled Trials (RCTs) evaluating non-pharmacological interventions in individuals with Mild Cognitive Impairment (MCI) and Subjective Cognitive Decline (SCC) in LMICs. We analysed study quality using the Mixed Methods Assessment Tool (MMAT), meta-analysed and synthesized evidence. We included 25 RCTs, from six countries (most in China, n=17), involving 1304 participants. Across the 15 studies for which there was sufficient data to meta-analyse, we found significant positive effects on cognitive outcomes favouring interventions [1.49 (standardised mean difference, 95% Confidence Interval= 1.06-1.93)]. There was significant publication bias. Using an a priori standard framework, we classified interventions into exercise, multidomain, and arts/creative expression. Group exercise [1.67, 1.24-2.11, n=8]. and multidomain [1.22, 0.22-2.21, n=5] had replicated evidence of effectiveness. There was insufficient data to meta-analyse the creative arts category. We identified one high quality, multi-modal intervention, which combined Chinese mind-body exercises and health education, reporting a positive outcome. The first robust dementia prevention trials are underway in LMICs, evaluating effectiveness of models developed in higher income countries. We propose greater consideration and investment in development of interventions that account for specific LMIC contexts from the outset, so they are acceptable and used by local services.HighlightsThere was evidence that group exercise and multimodal interventions were effective for people with memory concerns in LMICs.We identified publication bias in meta-analyses; the open science agenda is critical to improving care in LMICs and reducing global inequalities.Most included studies were conducted in China, reflecting a need for high-quality evidence from underrepresented regions, including Africa and Latin America.We propose greater investment in developing interventions that account for specific LMIC contexts from the outset, so they are acceptable and used by local services.

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“…Although there are various reports, controversy exists about dual-task interventions for the rehabilitation of patients with cognitive impairment and the efficacy of exercise programs to improve mood, depression, physical function, and ADL, along with improving cognitive function in older adults with cognitive impairment, is still insufficient. A recent systematic review and meta-analysis has reported positive effects of dual-task exercise on cognition and motor function in older adults with cognitive impairment, but several studies included in the systematic review compared experimental groups with control groups such as health education and placebo activities, not active comparators [ 29 ]. Studies in which the risk of selection bias existed were also included.…”

Section: Introductionmentioning

confidence: 99%

Effects of dual-task resistance exercise on cognition, mood, depression, functional fitness, and activities of daily living in older adults with cognitive impairment: a single-blinded, randomized controlled trial

Baek,

Hyeon,

Kim

et al. 2024

BMC Geriatr

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Background Regular exercise is emphasized for the improvement of functional capacity and independence of older adults. This study aimed to compare the effects of a dual-task resistance exercise program and resistance exercise on cognition, mood, depression, physical function, and activities of daily living (ADL) in older adults with cognitive impairment. Methods A total of 44 older adults participated in the study. Participants were randomly allocated to an experimental group (n = 22) performing a dual-task resistance exercise program for cognitive function improvement and a control group (n = 22) performing a resistance exercise program. Both groups performed the exercise for 40 min per session, three times a week, for 6 weeks (18 sessions). Cognition, mood, depression, functional fitness, and ADL were quantified before and after the intervention using the Mini-Mental State Examination (MMSE), profile of mood states (POMS), geriatric depression scale (GDS), senior fitness test (SFT), and Korean version of ADL, respectively. Results There was a significant time and group interaction on the MMSE (p = 0.044). There were no significant time and group interactions in the POMS, GDS, SFT, or ADL. Cognitive function (p < 0.001), mood (p < 0.001), depression (p < 0.001), functional fitness (p < 0.001), and ADL (p < 0.001) significantly improved after dual-task resistance exercise, and cognitive function (p < 0.001), mood (p < 0.001), depression (p < 0.001), functional fitness (p < 0.001), and ADL (p < 0.001) significantly improved after resistance exercise. Conclusions Dual-task resistance exercise is more effective than resistance exercise in improving cognitive function in older adults with cognitive impairment. Both dual-task resistance exercise and resistance exercise improves mood, depression, functional fitness, and ADL after the intervention. We propose using dual-task resistance exercises for cognitive and physical health management in the older adults with cognitive impairment. Trial registration This study was registered with the Clinical Research Information Service (WHO International Clinical Trials Registry Platform) (Registration ID, KCT0005389; Registration date, 09/09/2020).

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Aerobic exercise and dual-task training combination is the best combination for improving cognitive status, mobility and physical performance in older adults with mild cognitive impairment

Cited by 8 publications

References 52 publications

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Mid-Term and Long-Lasting Psycho–Cognitive Benefits of Bidomain Training Intervention in Elderly Individuals with Mild Cognitive Impairment

Lifestyle interventions for dementia prevention in Low- and Middle-Income Countries: A systematic review

Effects of dual-task resistance exercise on cognition, mood, depression, functional fitness, and activities of daily living in older adults with cognitive impairment: a single-blinded, randomized controlled trial

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