Aerobic Exercise Attenuates Kidney Injury, Improves Physical Performance, and Increases Antioxidant Defenses in Lungs of Adenine-Induced Chronic Kidney Disease Mice

Moecke, Débora Melissa Petry; Martins, Gisele Henrique Cardoso; Garlet, Thaine Cristina; Bonorino, Kelly Cattelan; Luciani, Marília Gabriela; Bion, Monique; Santos, Barbara dos; Gevaerd, Monique da Silva; Filho, Jamil Assreuy; Santos, Adair Roberto Soares; Vieira, Dioracy Fonterrada; Dafré, Alcir Luiz; Kunzler, Deborah de Camargo Hizume

doi:10.1007/s10753-022-01643-y

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…Previous studies have supported that CT increases the efficiency of immune function, decreases serum levels of markers of inflammation, and also suppresses nuclear factor‐κB (NF‐κB) signalling and its proinflammatory targets interleukin (IL)‐6 and TNF‐α in rats (Liu & Chang, 2018 ; Petersen & Pedersen, 2005 ). It has been shown that exercise can increase antioxidant defences in mouse lungs and other tissues and prevent lipid peroxidation and oxidative damage to proteins in lung damage (Moecke et al., 2022 ; So et al., 2021 ). Therefore, considering the role of exercise in altering the balance of oxidative and anti‐oxidative species, we aimed to compare the pretreatment and therapeutic effects of continuous training on acute lung injury by Mtx.…”

Section: Introductionmentioning

confidence: 99%

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Rajizadeh,

Hosseini,

Bahrami

et al. 2023

Experimental Physiology

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Methotrexate (Mtx) is used to treat various diseases, including cancer, arthritis and other rheumatic diseases. However, it induces oxidative stress and pulmonary inflammation by stimulating production of reactive oxygen species and cytokines. Considering the positive effects of physical activity, our goal was to investigate the preventive and therapeutic role of continuous training (CT) on Mtx‐induced lung injury in rats. The rats were divided into five groups of 14 animals: a control group (C); a continuous exercise training group (CT; healthy rats that experienced CT); an acute lung injury with Mtx group (ALI); a pretreatment group with CT (the rats experienced CT before ALI induction), and a post‐treatment group with CT (the rats experienced CT after ALI induction). One dose of 20 mg/kg Mtx intraperitoneal was administered in the Mtx and training groups. Forty‐eight hours after the last exercise session all rats were sacrificed. According to our results, the levels of tumour necrosis factor‐α (TNF‐α), malondialdehyde (MDA), myeloperoxidase (MPO), GATA binding protein 3 (GATA3) and caspase‐3 in the ALI group significantly increased compared to the control group, and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), interleukin‐10 (IL‐10), forkhead box protein 3 (FOXP3), and T‐bet decreased. In contrast, compared to the acute lung injury group, pretreatment and treatment with CT reduced TNF‐α, MDA, MPO, GATA3 and caspase‐3 and increased SOD, GPX, TAC, IL‐10, FOXP3 and T‐bet levels. The effects of CT pretreatment were more significant than the effects of CT post‐treatment. Continuous exercise training effectively reduced oxidative stress and inflammatory cytokines and ameliorated Mtx‐induced injury, and the effects of CT pretreatment were more significant than the effects of CT post‐treatment.New Findings What is the central question of this study? Considering the high prevalence of lung injury in society, does exercise as a non‐pharmacological intervention have ameliorating effects on lung injury? What is the main finding and its importance? Exercise can have healing effects on the lung after pulmonary injury through reducing inflammation, oxidative stress and apoptosis. Considering the lower side effects of exercise compared to drug treatments, the results of this study may be useful in the future.

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Section: Introductionmentioning

confidence: 99%

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Rajizadeh,

Hosseini,

Bahrami

et al. 2023

Experimental Physiology

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Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease

Okamoto,

Kasukawa,

Nozaka

et al. 2024

Applied Sciences

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This study evaluated changes over time in skeletal muscle atrophy, expressions of skeletal muscle anabolic and catabolic genes, and mitochondrial activity by skeletal muscle type in an adenine-induced chronic kidney disease (CKD) model. A CKD model was successfully established by feeding male Wistar rats a 0.75% adenine diet for 4 weeks starting at 8 weeks of age. Control and CKD groups were sacrificed at 12 and 20 weeks of age. The back muscles were analyzed histologically, and succinate dehydrogenase (SDH) staining was performed to evaluate mitochondrial activity. Gene expressions of myogenic determination gene number 1 and myogenin as indicators of muscle anabolism, atrogin-1 and muscle RING-finger protein-1 (MuRF1) as indicators of muscle catabolism, and peroxisome proliferator-activated receptor-γ coactivator-1-α as a marker of mitochondrial biogenesis were assessed. Type I and type II muscle cross-sectional areas (CSAs) were decreased at 12 weeks, but type I muscle CSA was recovered at 20 weeks. SDH staining was lower in CKD than in control rats at 12 weeks, but no significant difference was observed at 20 weeks. Increased expressions of myogenin, atrogin-1, and MuRF-1 were observed only at 12 weeks, but no differences were observed at 20 weeks. The adenine-induced CKD rat model appears to show changes in muscle atrophy over time.

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Aerobic Exercise Attenuates Kidney Injury, Improves Physical Performance, and Increases Antioxidant Defenses in Lungs of Adenine-Induced Chronic Kidney Disease Mice

Cited by 2 publications

References 62 publications

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease

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