Aerobic exercise attenuates the effects of ovariectomy and sedentarism on body composition and food intake in female rats

Franco, Frederico Souzalima Caldoncelli; Natali, Antônio José; Costa, Neuza Maria Brunoro

doi:10.1590/1678-9865202134e200263

Cited by 1 publication

(1 citation statement)

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“…Also, the results showed that body mass and AT + DE groups, in which food intake was also the least in the 8th and 10th weeks, suggesting that body mass loss may be associated with energy expenditure with performing exercise and hence food intake may also decrease. In agreement with previous studies, AT can decrease food intake and increase energy consumption (Baek et al, 2020;Franco et al, 2021). Our results support the findings of Baek et al who reported that the AT + HFD (6 weeks, 15-20 m/min, 30-60 min) group was lower body mass in obese rats compared with the obese control group (Baek et al, 2020).…”

Section: Discussionsupporting

confidence: 93%

Hydroalcoholic extract of dill and aerobic training prevents high‐fat diet‐induced metabolic risk factors by improving miR ‐33 and miR ‐223 expression in rat liver

Aliakbari

Saghebjoo

Sarir

et al. 2022

Journal of Food Biochemistry

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Exercise training and medicinal herb supplementation may improve microRNAs (miRNAs) expression associated with obesity. This study aimed to assess the effects of 10 weeks of aerobic training (AT) and dill extract (DE) on miR‐33 and miR‐223 expression of liver in high‐fat diet (HFD)‐induced obese rats. Forty male Wistar rats were fed a defined high‐fat (n = 32) and standard (n = 8, nonobese control [NC]) diet. After obesity induction, obese rats were randomly allocated to four groups: AT, DE, AT + DE, and obese control (OC). Rats were euthanized and plasma and liver tissue samples were collected after the intervention. The liver expression of miR‐33 was lower in the AT, DE, AT + DE, and NC groups compared with the OC group. Also, the liver miR‐223 expression was higher in the AT, DE, AT + DE, and NC groups compared with the OC group. Moreover, the liver expression of miR‐223 in the AT + DE group was higher compared with the AT and DE groups. The AT, DE, AT + DE, and NC groups had lower liver TC compared with the OC group. Also, the plasma level of apolipoprotein B (Apo B) was significantly lower, and liver HDL‐C was significantly higher in the AT + DE and NC groups compared with the OC group. These findings show that long‐term AT combined with the intake of DE may improve the plasma levels of Apo B, and TC and HDL‐C levels in the liver, which is probably due to AT and DE positive effects on miR‐33 and miR‐223 in the liver of obese rats. Practical applications Aerobic training reduces overweight and obesity health problems, however, the duration and intensity of the exercise training distinguish between individuals. We used an integrated approach combining pharmacological and non‐pharmacological as a medical strategy to prevent HFD‐induced metabolic injury in obese rats. The present results discovered that a combination of AT + DE intervention improves the miR‐33 and miR‐223 in the liver of obese rats.

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Section: Discussionsupporting

confidence: 93%