Aerobic exercise improves microvascular dysfunction in fructose fed hamsters

Boa, B.C.S.; Costa, Ramon R.; Souza, M.G.C.; Cyrino, Fátima Z. G. A.; Paes, L.S.; Miranda, Marcos L.; Carvalho, Jorge José de

doi:10.1016/j.mvr.2014.02.012

Cited by 14 publications

(13 citation statements)

References 38 publications

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“…Moreover, fructose is used faster than glucose, and more is converted to liver glycogen, thus an increase in the hepatic glycogen concentration was shown by us and others (Décombaz et al 2011;Basaranoglu et al 2013) in this model. All of these parameters were significantly attenuated in exercised-trained rats, indicating that maintenance of glucose homeostasis might be involved in the beneficial effects of physical training in metabolic diseases (Boa et al 2014;Machado et al 2014).…”

Section: Discussionmentioning

confidence: 97%

“…All of these parameters were significantly attenuated in exercised‐trained rats, indicating that maintenance of glucose homeostasis might be involved in the beneficial effects of physical training in metabolic diseases (Boa et al . ; Machado et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Aerobic exercise training may effectively mitigate fructose‐induced MS in rats, and it has been shown that it reduces visceral fat, increases high‐density lipoprotein–cholesterol, lowers plasma TAG and insulin concentrations and improves the homeostasis model assessment of insulin resistance (HOMA‐IR) and insulin signalling (Boa et al . ; Stanišić et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the intervention of exercise recovers hyperinsulinaemia and ameliorates insulin sensitivity to levels similar to the control animals, preventing the development of a prediabetic state (Kawamura et al 2002;Machado et al 2014). Aerobic exercise training may effectively mitigate fructose-induced MS in rats, and it has been shown that it reduces visceral fat, increases high-density lipoprotein-cholesterol, lowers plasma TAG and insulin concentrations and improves the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin signalling (Boa et al 2014;Stanišić et al 2016).…”

Section: Discussionmentioning

confidence: 99%

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Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Frantz

Medeiros

Giori

et al. 2017

Experimental Physiology

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What is the central question of this study? What are the effects of exercise training on the hepatic renin-angiotensin system and their contribution to damage resulting from fructose overload in rats? What is the main finding and its importance? Exercise training attenuated the deleterious actions of the angiotensin-converting enzyme/angiotensin II/angiotensin II type 1 receptor axis and increased expression of the counter-regulatory (angiotensin-converting enzyme 2/angiotensin (1-7)/Mas receptor) axis in the liver. Therefore, our study provides evidence that exercise training modulates the hepatic renin-angiotensin system, which contributes to reducing the progression of metabolic dysfunction and non-alcoholic fatty liver disease in fructose-fed rats. The renin-angiotensin system (RAS) has been implicated in the development of metabolic syndrome. We investigated whether the hepatic RAS is modulated by exercise training and whether this modulation improves the deleterious effects of fructose overload in rats. Male Wistar rats were divided into (n = 8 each) control (CT), exercise control (CT-Ex), high-fructose (HFr) and exercise high-fructose (HFr-Ex) groups. Fructose-drinking rats received d-fructose (100 g l ). After 2 weeks, CT-Ex and HFr-Ex rats were assigned to a treadmill training protocol at moderate intensity for 8 weeks (60 min day , 4 days per week). We assessed body mass, glucose and lipid metabolism, hepatic histopathology, angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) activity, the angiotensin concentration and the expression profile of proteins affecting the hepatic RAS, gluconeogenesis and inflammation. Neither fructose overload nor exercise training influenced body mass gain and serum ACE and ACE2 activity. The HFr group showed hyperinsulinaemia, but exercise training normalized this parameter. Exercise training was effective in preventing hepatic steatosis and in preventing triacylglycerol and glycogen accumulation. Furthermore, exercise improved the response to the deleterious effects of HFr overload by normalizing the gluconeogenesis pathway and the protein levels of interleukin-6 and tumour necrosis factor-α. The HFr rats displayed increased hepatic ACE activity and protein expression and angiotensin II concentration, which were attenuated by exercise training. Exercise training restored the ACE2/angiotensin-(1-7)/Mas receptor axis. Exercise training may favour the counter-regulatory ACE2/angiotensin-(1-7)/Mas receptor axis over the classical RAS (ACE/angiotensin II/angiotensin II type 1 receptor axis), which could be responsible for the reduction of metabolic dysfunction and the prevention of non-alcoholic fatty liver disease.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Frantz

Medeiros

Giori

et al. 2017

Experimental Physiology

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“…Studies have suggested that these improvements in HR may be due to increased vagal activity [17]. Boa et al [18] have demonstrated that aerobic ET undertaken for 4 weeks, following 20 weeks of fructose overload in young male hamsters, may improve microvascular and endothelium dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

et al. 2016

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The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40–60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)- SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.

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Low intensity exercise prevents disturbances in rat cardiac insulin signaling and endothelial nitric oxide synthase induced by high fructose diet

Stanišić

Korićanac

Ćulafić

et al. 2016

Molecular and Cellular Endocrinology

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Aerobic exercise improves microvascular dysfunction in fructose fed hamsters

Cited by 14 publications

References 38 publications

Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Exercise training modulates the hepatic renin–angiotensin system in fructose‐fed rats

Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

Low intensity exercise prevents disturbances in rat cardiac insulin signaling and endothelial nitric oxide synthase induced by high fructose diet

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