Aerobic Exercise with Mediterranean-DASH Intervention for Neurodegenerative Delay Diet Promotes Brain Cells’ Longevity despite Sex Hormone Deficiency in Postmenopausal Women: A Randomized Controlled Trial

Abstract

Objective. To investigate the combined impact of aerobic exercise and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on brain cells longevity in spite of sex hormones deficiency in obese postmenopausal women. Design. A parallel randomized clinical trial. Subjects/Patients. Sixty-eight eligible postmenopausal women were randomly assigned to one of two groups, one experimental and one control. The participants’ age ranged from 60 to 75 years, and their body mass index ranged from 30 to 39.9 kg/m2. Methods. An experimental group whose members followed moderate-intensity treadmill exercise three times/week for three months with MIND diet and a control group whose members followed the MIND diet only. In addition to serum sex hormones, pre- and post-12-week assessments were performed to measure serum sex hormones as well as cognitive and functional levels. Results. The experimental group showed after intervention highly significant changes ( p < 0.01 ) in sex hormones, cognitive functions, and functional levels compared with the control group ( p < 0.05 ). In addition, no correlation was found between the measured variables in both groups after intervention ( p > 0.05 ). Conclusion. Aerobic exercise combined with the MIND diet improves cognitive and functional levels and substitutes sex hormones deficiency in postmenopausal women, which affects the longevity of brain health.

Effectiveness of Aerobic Exercise with Laughter Therapy on Functional, Cognitive, and Psychological Well-Being in The Elderly: A Randomized Controlled Clinical Trial

“…Six-weeks of aerobic exercise and laughter therapy resulted in a significant increase in 6-MWTD, FIM, and MMSE scores (p <0.001) when compared to aerobic exercise alone (p <0.001), as noticed in this study, which is consistent with Dos Anjos et al (29) , who reported a significant impact of moderate intensity aerobic exercise on functional capacity in diabetic elderly (p <0.001), and Elsayed et al (30) results, which showed a significant effect of aerobic exercise on functional and cognitive level in elderly women (p <0.05).…”

Outcomes addressed in randomized controlled lifestyle intervention trials in community‐dwelling older people with (sarcopenic) obesity—An evidence map

“…Of 57,721 unique records, 109 articles of 54 studies were included in the evidence map as they provided information on outcomes assessed (Figure 1 and Table S4). 34–87 The unique accession numbers from all database searches are available upon request.…”

“…Obesity and sarcopenic obesity (SO) in older adults are major public health issues, due to their increasing prevalence. 1,2 Obesity prevalence among older adults (60 years and older) ranges from 20.9% in Europe to 43.3% in the United States. [3][4][5] The prevalence of SO is difficult to establish due to the different definitions and cutoffs applied.…”

Associations of the MIND Diet with Cardiometabolic Diseases and Their Risk Factors: A Systematic Review

“…Twelve of the studies were conducted in Iran, 39–41 , 49 , 53 , 54 , 57–59 , 61–63 one of which was an RCT. 40 The rest of the studies spanned across Egypt, 65 China, 42 , 51 , 64 the United States 48 , 55 , 56 , 60 and Australia. 47 , 50 , 52 …”