Aerobic or resistance training improves autonomic control of circulation in oophorectomized rats with cardiometabolic dysfunctions: Impact on renal oxidative stress

Brito-Monzani, Janaina de Oliveira; Stoyell‐Conti, Filipe Fernandes; Shecaira, Tânia Plens; Silva, Michel Pablo dos Santos Ferreira; Dias, Danielle da Silva; Bernardes, Nathália; Angelis, Kátia De

doi:10.1016/j.exger.2020.111181

Cited by 4 publications

(4 citation statements)

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“…In fact, there is consistent evidence that antioxidant defense increase in response to aerobic or resistance exercises in cardiac and kidney tissues [ 22 , 61 ]. Exercise training could induce activation of the nuclear factor erythroid 2-relatede factor 2 (Nrf2), which is a most important transcription factor recognized for regulating antioxidant response, acting on a specific portion of DNA, known as AREs (antioxidant response elements), encoding antioxidant enzymes, such as SOD, CAT, and GPx [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Concurrent exercise training induces additional benefits to hydrochlorothiazide: Evidence for an improvement of autonomic control and oxidative stress in a model of hypertension and postmenopause

Ferreira,

Santos Ferreira Silva,

da Silva Dias

et al. 2023

PLoS ONE

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Objective This study aimed to evaluate whether exercise training could contribute to a better modulation of the neurohumoral mechanisms linked to the pathophysiology of arterial hypertension (AH) in postmenopausal hypertensive rats treated with hydrochlorothiazide (HCTZ). Methods Female spontaneously hypertensive rats (SHR) (150−200g, 90 days old) were distributed into 5 hypertensive groups (n = 7–8 rats/group): control (C), ovariectomized (O), ovariectomized treated with HCTZ (OH), ovariectomized submitted to exercise training (OT) and ovariectomized submitted to exercise training and treated with HCTZ (OTH). Ovarian hormone deprivation was performed through bilateral ovariectomy. HCTZ (30mg/kg/day) and concurrent exercise training (3d/wk) were conducted lasted 8 weeks. Arterial pressure (AP) was directly recorded. Cardiac effort was evaluated using the rate-pressure product (RPP = systolic AP x heart rate). Vasopressin V1 receptor antagonist, losartan and hexamethonium were sequentially injected to evaluate the vasopressor systems. Inflammation and oxidative stress were evaluated in cardiac tissue. Results In addition to the reduction in AP, trained groups improved RPP, AP variability, bradycardic (OT: −1.3 ± 0.4 and OTH: −1.6 ± 0.3 vs. O: −0.6 ± 0.3 bpm/mmHg) and tachycardic responses of baroreflex sensitivity (OT: −2.4 ± 0.8 and OTH: −2.4 ± 0.8 vs. O: −1.3 ± 0.5 bpm/mmHg), NADPH oxidase and IL-10/TNF-α ratio. Hexamethonium injection revealed reduced sympathetic contribution on basal AP in OTH group (OTH: −49.8 ± 12.4 vs. O: −74.6 ± 18.1 mmHg). Furthermore, cardiac sympathovagal balance (LF/HF ratio), IL-10 and antioxidant enzymes were enhanced in OTH group. AP variability and baroreflex sensitivity were correlated with systolic AP, RPP, LF/HF ratio and inflammatory and oxidative stress parameters. Conclusion The combination of HCTZ plus concurrent exercise training induced additional positive adaptations in cardiovascular autonomic control, inflammation and redox balance in ovariectomized SHR. Therefore, combining exercise and medication may represent a promising strategy for managing classic and remaining cardiovascular risks in AH.

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Section: Discussionmentioning

confidence: 99%

Concurrent exercise training induces additional benefits to hydrochlorothiazide: Evidence for an improvement of autonomic control and oxidative stress in a model of hypertension and postmenopause

Ferreira,

Santos Ferreira Silva,

da Silva Dias

et al. 2023

PLoS ONE

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“…The mechanisms involved in the increase in BPV are not completely elucidated yet. Importantly, we have showed a relationship between increased BPV and lipoperoxidation [ 8 ], suggesting that the reduction of BP oscillation may contribute to the prevention of target organ damage.…”

Section: Introductionmentioning

confidence: 99%

Impact of exercise training associated with enalapril treatment on blood pressure variability and renal dysfunctions in an experimental model of arterial hypertension and postmenopause

dos Santos Ferreira Silva,

Ferreira,

Shecaira

et al. 2024

PLoS ONE

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Objective In this study, we aimed to investigate the effects of the concurrent exercise training (CET) associated with the enalapril maleate on blood pressure variability (BPV) and renal profile in an experimental model of arterial hypertension (AH) and postmenopause. Methods Female ovariectomized spontaneously hypertensive rats (SHR) were distributed into 4 groups (n = 8/group): sedentary (SO), sedentary + enalapril (SOE), trained (TO) and trained + enalapril (TOE). Both enalapril (3mg/kg) and CET (3 days/week) were conducted during 8 weeks. Blood pressure (BP) was directly recorded for BPV analyses. Renal function, morphology, inflammation and oxidative stress were assessed. Results The SOE, TO e TOE groups presented decreased systolic BP compared with SO. Both trained groups (TO and TOE) presented lower BPV and increased baroreflex sensitivity (TO: 0.76 ± 0.20 and TOE: 1.02 ± 0.40 vs. SO: 0.40 ± 0.07 ms/mmHg) compared with SO group, with additional improvements in TOE group. Creatinine and IL-6 levels were reduced in SOE, TO and TOE compared with SO group, while IL-10 was increased only in TOE group (vs. SO). Enalapril combined with CET promote reduction in lipoperoxidation (TOE: 1.37 ± 0.26 vs. SO: 2.08 ± 0.48 and SOE: 1.84 ± 0.35 μmol/mg protein) and hydrogen peroxide (TOE: 1.89 ± 0.40 vs. SO: 3.70 ± 0.19 and SOE: 2.73 ± 0.70 μM), as well as increase in catalase activity (vs. sedentary groups). The tubulointerstitial injury was lower in interventions groups (SOE, TO and TOE vs. SO), with potentialized benefits in the trained groups. Conclusions Enalapril combined with CET attenuated BPV and baroreflex dysfunctions, probably impacting on end-organ damage, as demonstrated by attenuation in the AH-induced renal inflammations, oxidative stress and morphofunctional impairments in postmenopausal rats.

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“…16 Previously, resistance training did not reverse blood pressure, cardiovascular autonomic and baroreflex impairment in ovarian deprivation model with hypertension or metabolic dysfunction. 17,18 European Society of Cardiology (ESC) and American heart association (AHA) guidelines recommend the combination of aerobic plus resistance training as level of evidence A for cardiovascular prevention in adults. 19,20 Experimentally, cardiovascular effects of resistance 5,17,18 or combined training in ovariectomized animals are scarce, 21,22 as well as aerobic, resistance or combined training comparison in ovariectomized animals.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 European Society of Cardiology (ESC) and American heart association (AHA) guidelines recommend the combination of aerobic plus resistance training as level of evidence A for cardiovascular prevention in adults. 19,20 Experimentally, cardiovascular effects of resistance 5,17,18 or combined training in ovariectomized animals are scarce, 21,22 as well as aerobic, resistance or combined training comparison in ovariectomized animals. 23 Thus, the aim of this study was to compare the cardiovascular and metabolic effects of aerobic, resistance, or combined training (aerobic plus resistance) in an experimental menopause model.…”

Section: Introductionmentioning

confidence: 99%

Combined Exercise Training Promotes More Benefits on Cardiovascular Autonomic Modulation in Ovariectomized Rats Than Isolated Aerobic or Resistance Training

Costa‐Santos¹,

Costa²,

Dos-Santos³

et al. 2023

DMSO

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Introduction: Cardiovascular risk increase after ovarian deprivation has been extensively demonstrated by our research group through cardiovascular autonomic analysis. Interventions involving different types of exercises, such as resistance exercises or combined exercises (aerobic and resistance) have been widely recommended to prevent or minimize neuromuscular decline in postmenopausal women, which is aggravated by a sedentary lifestyle. Experimentally, the cardiovascular effects of resistance or combined training, as well as comparison between aerobic, resistance, and combined training, in ovariectomized animals are scarce. Purpose: In this study, we hypothesized that the combination of aerobic and resistance training may be more effective in preventing muscle mass loss, as well as improving cardiovascular autonomic modulation and baroreflex sensitivity, than aerobic or resistance training individually in ovariectomized rats. Animals and Methods: Female rats were divided into 5 groups: sedentary (C); ovariectomized (Ovx); trained ovariectomized submitted to aerobic training (OvxAT); resistance training (OvxRT); combined training (OvxCT). Exercise training lasted 8 weeks, with the combined group alternating between aerobic training and resistance training every other day. At the end of the study, glycemia and insulin tolerance were evaluated. Arterial pressure (AP) was directly recorded. Baroreflex sensitivity was assessed by heart rate response to changes in arterial pressure. Cardiovascular autonomic modulation was evaluated by spectral analysis. Results: Combined training was the only training regime that increased baroreflex sensitivity for tachycardic response and reduced all systolic blood pressure variability parameters. Furthermore, all animals submitted to exercise training on a treadmill (OvxAT and OvxCT) presented lower systolic, diastolic, and mean pressure, as well as improvements in the autonomic modulation for the heart. Conclusion:Combined training showed to be more effective than isolated aerobic and resistance training, mixing the isolated benefits of each modality. It was the only modality able to increase baroreflex sensitivity to tachycardic responses, reduce arterial pressure and all parameters of vascular sympathetic modulation.

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Aerobic or resistance training improves autonomic control of circulation in oophorectomized rats with cardiometabolic dysfunctions: Impact on renal oxidative stress

Cited by 4 publications

References 48 publications

Concurrent exercise training induces additional benefits to hydrochlorothiazide: Evidence for an improvement of autonomic control and oxidative stress in a model of hypertension and postmenopause

Concurrent exercise training induces additional benefits to hydrochlorothiazide: Evidence for an improvement of autonomic control and oxidative stress in a model of hypertension and postmenopause

Impact of exercise training associated with enalapril treatment on blood pressure variability and renal dysfunctions in an experimental model of arterial hypertension and postmenopause

Combined Exercise Training Promotes More Benefits on Cardiovascular Autonomic Modulation in Ovariectomized Rats Than Isolated Aerobic or Resistance Training

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