In the pursuit of a lighter composite wing design, fast and effective methodologies for sizing and validating the wing members (e.g., spar, ribs, skins, etc.) are required. In the present paper, the preliminary design methodology of an airliner main composite wing, which has an innovative multispar configuration instead of the conventional two-spar design, is investigated. The investigated aircraft wing is a large-scale composite component, requiring an efficient analysis methodology; for this purpose, the initial wing sizing is mostly based on simplified Finite Element (FE) stress analysis combined to analytically formulated design criteria. The proposed methodology comprises three basic modules, namely, computational stress analysis of the wing structure, comparison of the stress–strain results to specific design allowable and a suitable resizing procedure, until all design requirements are satisfied. The design constraints include strain allowable for the entire wing structure, stability constraints for the upper skin and spar webs, as well as bearing bypass analysis of the riveted/bolted joints of the spar flanges/skins connection. A comparison between a conventional (2-spar) and an innovative 4-spar wing configuration is presented. It arises from the comparison between the conventional and the 4-spar wing arrangement, that under certain conditions the multispar configuration has significant advantages over the conventional design.