Aeromonas salmonicida infection kinetics and protective immune response to vaccination in sablefish (Anoplopoma fimbria)

CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues

“…The colocalization of CD10 and ASMA in normal lumpfish retina is intriguing but requires further study. The CD10 expression in normal retina is also reminiscent of the expression of CD10 in sable fish brain (47). Since ASMA is known to be expressed by neural crest cell derived lineages (69,70), further work could explore if ASMA-like expression in C. lumpus retina is functionally related to CD10 or other properties of retinal nervous tissue in health and disease states.…”

“…The high number of CD10+ cells in myxozoan infected ocular cartilage tissue raises questions about the level of specificity of this immune response. While lumpfish are known to express genes coding for components of specific immune responses (i.e., as mediated by T and B lymphocytes) and have been demonstrated to mount measurable specific immune responses (42,47,59,60), less is known about innate immune responses in lumpfish. However, lumpfish B lymphocytes are known to be phagocytic (60), suggesting that unique forms of innate immunity could exist in lumpfish.…”

“…In addition, amino acids 450-550 of the human CD10 protein sequence share 22 regions of 100% identity with the lumpfish CD10 orthologue. Moreover, we have recently successfully utilized this anti-CD10 antibody to stain CD10 positive cells in an experimental infection scenario in various tissues of other teleosts (47). Using this antibody we identified specific and distinctive CD10 expression in lumpfish head kidney, a tissue rich in lymphoid cells (48), and in the lumpfish eye ( Figure 11).…”

Status of sablefish, Anoplopoma fimbria, aquaculture

“…Sablefish susceptibility to atypical A. salmonicida strain J410, a strain isolated from infected cultured sablefish, was also demonstrated in a study by Vasquez et al (2020) (Table 5). The authors developed a model of infection kinetics, finding that atypical A. salmonicida strain J410 has lower virulence in sablefish than some A. salmonicida strains infecting trout, but still exhibits high morbidity.…”

“…The delivery route that is most effective for protecting fish depends on variables, such as fish size, the pathogen and its route of infection, water temperature, safety, and ontological development of the host (Dadar et al, 2017;Sudheesh & Cain, 2017). Thus far, injectable and immersion vaccines have been tested for use in sablefish with the pathogen A. salmonicida (Arkoosh et al, 2018;Vasquez et al, 2020).…”