Horizontal and vertical distributions of aerosol properties in the Taklimakan Desert (TD), North central region of China (NCR),North China Plain(NCP), and Yangtze River Delta (YRD) were investigated by statistical analysis using Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) L3 data from 2007 to 2020, to identify the similarities and differences in atmospheric aerosols in different regions, and evaluate the impact of pollution control policies developed in China in 2013 on aerosol properties in the study area. The aerosol optical depth (AOD) distribution had substantial seasonal and spatial distribution characteristics. AOD had high annual averages in TD (0.38), NCP (0.49), and YRD (0.52). However, these rates showed a decline post-implementation of the long-term pollution control policies; AOD values declined by 5%, 13.8%, 15.5%, and 23.7% in TD, NCR, NCP, and YRD respectively when comparing 2014–2018 to 2007–2013, and by 7.8%, 11.5%, 16%, and 10.4% when comparing 2019–2020 to 2014–2018. The aerosol extinction coefficient showed a clear regional pattern and a tendency to decrease gradually as height increased. Dust and polluted dust were responsible for the changes in AOD and extinction coefficients between TD and NCR and NCP and YRD, respectively. In TD, with change of longitude, dust aerosol first increased and then decreased gradually, peaking in the middle. Similarly in NCP, polluted dust aerosol first increased and then decreased, with a maximum value in the middle. The elevated smoke aerosols of NCP and YRD were significantly higher than those observed in TD and NCR. The high aerosol extinction coefficient values (>0.1 km−1) were mainly distributed below 4 km, and the relatively weak aerosol extinction coefficients (>0.001 km−1) were mainly distributed between 5–8 km, indicating that the high-altitude long-range transport of TD and NCR dust aerosols affects NCP and YRD.