Aerosolized hyaluronic acid decorated, ferulic acid loaded chitosan nanoparticle: A promising asthma control strategy

Dhayanandamoorthy, Yamini; Antoniraj, M. Gover; Kandregula, Chaya A. Babu; Kandasamy, Ruckmani

doi:10.1016/j.ijpharm.2020.119958

Cited by 50 publications

(22 citation statements)

References 45 publications

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“…In vitro drug release, mucoadhesive properties, in vitro cell viability and permeability studies, stability studies [194] Mn-TMC NPs Ionic gelation (TPP) Etofylline (ETO) Asthma treatment Sustained drug release, biodegradation studies, stability, safety, and aerodynamic behavior [195] HA/CS NPs Self-assembly Ferulic acid (FA) Asthma treatment In vivo inhalation toxicity assessment [196]…”

Section: Rifampicin (Rif) Tuberculosis Treatmentmentioning

confidence: 99%

“…They are effective for lung cancer treatment in association with improved drug accumulation inside the tumors due to facilitating their passive as well as active delivery [193,228]. NPs are also used to treat mucus hypersecretion and severe inflammatory lung diseases namely asthma [196], cystic fibrosis, and chronic obstructive pulmonary disease [195] due to their ability to provide sustained drug release, overcome airway hypersecretion, and target diseased cells or tissues through matrix decoration with a homing device.…”

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

“…Vibrating mesh nebulizers are recognized as the most efficient actuation technique over conventional inhalers for drug deposition. Dhayanandamoorthy et al [196] explored hyaluronic acid (HA) decorated, ferulic acid (FA) loaded chitosan NPs (FA-HA/CS NPs) aerosolized using vibrating mesh nebulizer as a strategic combination of drug, nanocarrier, and delivery device for effective asthma control. In vivo inhalation toxicity assessment confirmed safety, while FA-HA/CS NPs prophylaxis mitigated the inflammation, airway hypersensitivity, and remodeling in OVA-induced mice models of asthma.…”

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

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Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

299

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Rifampicin (Rif) Tuberculosis Treatmentmentioning

confidence: 99%

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

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Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

299

120

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“…According to the developers of this product, Novochizol aerosols can provide a therapeutic dose to a patient for a period ranging from 25 min to 3 h. Using chitosan as nanoparticle provides a lot of benefits such as low toxicity and biodegradability in both in vitro and in vivo model. Furthermore, research on chitosan shows very good applicability in drug transport to lungs [33]. Therefore, chitosan nanoparticle may be the potential alternative to use it in transport of drug against SARS-CoV-2.…”

Section: Nanoparticle As Therapeutic Agent Against Covid-19mentioning

confidence: 99%

New insights into application of nanoparticles in the diagnosis and screening of novel coronavirus (SARS-CoV-2)

et al. 2021

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Novel coronavirus disease 2019 is by far the worst pandemic disease in the current millennium. The first human-tohuman transmission was observed in December 2019 in China and is caused by the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected millions of people within months across the globe. SARS-CoV-2 is a spike protein enveloped virus with particle-like characteristics and a diameter of 60-140 nm. Real-time PCR, reverse transcriptase PCR, isothermal PCR, immunological-based detection technique and nano-based diagnostic system have been explained for the identification and differentiation of different types of virus including SARS-COV-2. Synthetic nanoparticles can closely mimic the virus and interact strongly with its virulent proteins due to their morphological similarities. Some of the antiviral nanomaterials are also discussed, for example zinc oxide nanoparticle is an antiviral agent with a tetrapod morphology that mimics the cell surface by interacting with the viral capsid. It suppressed the viral proteins upon UV radiation due to reaction caused by photocatalysis. Hence, nanoparticle-based strategies for tackling viruses have immense potential. The second part of the review points to the latest in vitro and in vivo procedures for screening viral particles and the usage of nanoparticles in diagnostic and therapeutics. This would be beneficial for early detection and assists for the safe and effective therapeutic management of COVID-19.

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“…[ 23–25 ] Nanoencapsulation has become an alternative for improving delivery of both CUR and FA in oral delivery, as studies have shown that several types of nanovehicles can be used in order to increase water solubility, permeability and protection to the low pH of the stomach. [ 26–29 ] In this work, both native and chemical modified (acetylation and citric acid cross‐linking) cassava starch SNPs were used for nanoencapsulation of FA and CUR. Studies were focused in understanding the effect of the chemical modification of SNPs on encapsulation efficiency of both bioactive molecules.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Release Kinetics of Bioactive Molecules from Native and Modified Starch Nanoparticles into Food and Gastric Simulants

2021

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Starch nanoparticles (SNPs) show great potential to be used as carriers of bioactive molecules, due to their biocompatibility and relative easy synthesis. Furthermore, SNPs can be tailored to have specific properties through chemical modifications such as acetylation and citric acid cross linking, among others. Curcumin (CUR) and ferulic acid (FA) are two polyphenols extracted from turmeric and corn, respectively, that are known for several biological activities, specially their antioxidant capability. In this paper, native (NSNP), acetylated (ASNP) and citric acid cross‐linked (CaSNP) starch nanoparticles are used as carries of CUR and FA. Structural characterization through FTIR and XRD shows that bioactive molecules are incorporated into the starch carriers, and that specific interactions, specially hydrogen bonds, allows higher encapsulation in the modified SNPs. Likewise, release kinetics in food simulant media are studies. Mathematical modeling shows that diffusion is the main force for both CUR and FA release, and that kinetics are heavily influenced by the nature of the release media.

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Aerosolized hyaluronic acid decorated, ferulic acid loaded chitosan nanoparticle: A promising asthma control strategy

Cited by 50 publications

References 45 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

New insights into application of nanoparticles in the diagnosis and screening of novel coronavirus (SARS-CoV-2)

Comparison of the Release Kinetics of Bioactive Molecules from Native and Modified Starch Nanoparticles into Food and Gastric Simulants

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