AES and EELS study of alumina model catalyst supports

Stará, I.; Zeze, Dagou A.; Matolín, Vladimı́r; Pavluch, J.; Gruzza, B.

doi:10.1016/s0169-4332(96)00582-x

Cited by 26 publications

(8 citation statements)

References 18 publications

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“…Comparison to references shows no Al oxides have plasmon peaks at 15 eV. [19] This result confirms that Al-rich regions are formed at and near the pore edge due to the preferential desorption of O.…”

Section: Resultssupporting

confidence: 67%

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al₂O₃ Nanopore Sensors

Venkatesan

Shah

Zuo

et al. 2010

Adv Funct Materials

169

166

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A new solid-state, Al2O3 nanopore sensor with enhanced surface properties for the real-time detection and analysis of individual DNA molecules is reported. Nanopore formation using electron beam based decomposition transformed the local nanostructure and morphology of the pore from an amorphous, stoichiometric structure (O to Al ratio of 1.5) to a hetero-phase crystalline network, deficient in O (O to Al ratio of ~0.6). Direct metallization of the pore region was observed during irradiation, thereby permitting the potential fabrication of nano-scale metallic contacts in the pore region with potential application to nanopore-based DNA sequencing. Dose dependent phase transformations to purely γ and/or α-phase nanocrystallites were also observed during pore formation allowing for surface charge engineering at the nanopore/fluid interface. DNA transport studies revealed an order of magnitude reduction in translocation velocities relative to alternate solid-state architectures, accredited to high surface charge density and the nucleation of charged nanocrystalline domains. The unique surface properties of Al2O3 nanopore sensors makes them ideal for the detection and analysis of ssDNA, dsDNA, RNA secondary structures and small proteins. These nano-scale sensors may also serve as a useful tool in studying the mechanisms driving biological processes including DNA-protein interactions and enzyme activity at the single molecule level.

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Section: Resultssupporting

confidence: 67%

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al₂O₃ Nanopore Sensors

Venkatesan

Shah

Zuo

et al. 2010

Adv Funct Materials

169

166

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show abstract

“…These results are caused by the removal of oxygen from the sapphire surface to form an Al-terminated surface. The removal of oxygen and the shift of the Al-O peak towards lower energy were also reported by Stara et al [24] when the sapphire surface was heated under vacuum or ion bombardment. Although the surface treatment methods are different, all treatments have similar effects on shifting the Al-O peak due to the removal of oxygen from the sapphire surface.…”

Section: Resultssupporting

confidence: 77%

2H-silicon carbide epitaxial growth on c-plane sapphire substrate using an AlN buffer layer and effects of surface pre-treatments

Luong

Tran

et al. 2015

Electron. Mater. Lett.

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“…The diffraction pattern of figure 19b confirms that initial electron beam exposure to the amorphous material nucleates several crystal phases. [141] This result confirms that Al-rich regions are formed at and near the pore edge due to the preferential desorption of O.…”

Section: Electron Diffractionsupporting

confidence: 67%

Solid-State Nanopore Sensors for Nucleic Acid Analysis

Venkatesan

Bashir

2011

Nanopores

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Nanopore DNA analysis is an emerging technique that involves electrophoretically driving DNA molecules through a nano-scale pore in solution and monitoring the corresponding change in ionic pore current. This versatile approach permits the label-free, amplification-free analysis of charged polymers (single stranded DNA, double stranded DNA and RNA) ranging in length from single nucleotides to kilobase long genomic DNA fragments with subnanometer resolution.Recent advances in nanopores suggest that this low-cost, highly scalable technology could lend itself to the development of third generation DNA sequencing technologies, promising rapid and reliable sequencing of the human diploid genome for under $1000.Here, we report the development of versatile, nano-manufactured Al 2 O 3 solid-state nanopores and nanopore arrays for rapid, label-free, single-molecule detection and analysis of DNA and protein. This nano-scale technology has proven to be reliable, affordable, and mass producible, and allows for integration with VLSI processes. A detailed characterization of nanopore performance in terms of electrical noise, mechanical robustness and materials analysis is provided, and the functionality of this technology in experimental DNA biophysics is explored.A framework for the application of this technology to medical diagnostics and sequencing is also presented. Specifically, studies involved the detection of DNA-protein complexes, a viable strategy in screening methylation patterns in panels of genes for early cancer detection, and the creation of lipid bilayer coated nanopore sensors, useful in creating hybrid biological/solid-state nanopores for DNA sequencing applications.The concept of a gated nanopore is also presented with preliminary results. The fabrication of this novel system has been enabled by the recent discovery of graphene, a highly versatile material with remarkable electrical and mechanical properties. Direct modulation of the nanopore conductance was observed through the application of potentials to the graphene gate.These exciting results suggest this technology could potentially be useful in slowing down or trapping a DNA molecule in the pore, thereby enabling solid-state nanopore sequencing.iii

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AES and EELS study of alumina model catalyst supports

Cited by 26 publications

References 18 publications

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al₂O₃ Nanopore Sensors

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al₂O₃ Nanopore Sensors

2H-silicon carbide epitaxial growth on c-plane sapphire substrate using an AlN buffer layer and effects of surface pre-treatments

Solid-State Nanopore Sensors for Nucleic Acid Analysis

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AES and EELS study of alumina model catalyst supports

Cited by 26 publications

References 18 publications

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al2O3 Nanopore Sensors

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al2O3 Nanopore Sensors

2H-silicon carbide epitaxial growth on c-plane sapphire substrate using an AlN buffer layer and effects of surface pre-treatments

Solid-State Nanopore Sensors for Nucleic Acid Analysis

Contact Info

Product

Resources

About

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al₂O₃ Nanopore Sensors

DNA Sensing Using Nanocrystalline Surface‐Enhanced Al₂O₃ Nanopore Sensors