Aetiological distribution of pulmonary hypertension and the value of transthoracic echocardiography screening in the respiratory department: A retrospective analysis from China

Abstract

Methods The aetiological composition and clinical characteristics of patients with pulmonary hypertension (PH) hospitalised in the respiratory department were retrospectively analysed, as well as the correlation between transthoracic echocardiography (TTE) and right heart catheterization (RHC) for evaluating pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP). Results Of 731 patients, 544 (74.42%) were diagnosed with PH by RHC. Pulmonary arterial hypertension (PAH) was the most common type of PH, accounting for 30.10%; PH due to lung disease and/or hypoxia accounted for 20.79%, and PH due to pulmonary artery obstructions accounted for 19.29%. TTE has the highest specificity for diagnosing PH due to pulmonary artery obstructions. The specificity was 0.9375, the sensitivity was 0.7361 and the area under the ROC curve (AUC) was 0.836. PASP, and mPAP estimated by TTE were different for various types of PH. In terms of PASP, TTE overestimated PASP in PH due to lung disease and/or hypoxia, but there was no significant difference compared with RHC (P > 0.05). TTE underestimates PAH patients' PASP compared with RHC. In terms of mPAP, TTE underestimated the mPAP of all types of PH, as there was a significant difference in the TTE‐estimated mPAP of patients with PAH compared with RHC but not on other types of PH. Pearson correlation analysis of TTE and RHC showed a moderate overall correlation (rPASP 0.598, P < 0.001; rmPAP 0.588, P < 0.001). Conclusions Among the patients with PH in the respiratory department, patients with PAH accounted for the majority. TTE has high sensitivity and specificity for the diagnosis of PH due to pulmonary artery obstructions in the respiratory department.

Derivation and Internal Validation of Prediction Models for Pulmonary Hypertension Risk Assessment in a Cohort Inhabiting Tibet, China

“…A clinical study involving 731 patients in China found no significant difference between RHC and TTE in assessing sPAP in PH caused by hypoxia. Furthermore, Pearson correlation analysis between RHC and TTE demonstrated a moderate overall correlation (Hong et al, 2023;McGoon et al, 2004;Xu & Jing, 2009).…”

“…Furthermore, Pearson correlation analysis between RHC and TTE demonstrated a moderate overall correlation (Hong et al, 2023;McGoon et al, 2004;Xu & Jing, 2009).…”

“…The copyright holder for this preprint this version posted April 30, 2024. ; https://doi.org/10.1101/2024.04.29.24306542 doi: medRxiv preprint Furthermore, Pearson correlation analysis between RHC and TTE demonstrated a moderate overall correlation (Hong et al, 2023;McGoon et al, 2004;Xu & Jing, 2009).…”