Aetiology and outcome in 53 cases of native valve staphylococcal endocarditis

Abstract

SummaryWithin the last 30 years the profile of infective endocarditis has altered considerably with regard to microbiological causation, clinical features, and natural history. A contributory factor has undoubtedly been the development of potent antibiotics and their sometimes indiscriminate use. The increase in intravenous drug abuse in urban centres, the use of immunosuppressive agents, and the use of prosthetic heart valves have also all contributed. Although cardiac surgery in the uninfected heart provides a perfect environment for infective endocarditis, the improved design of prosthetic valves and the enhanced long-term survival and decreased immediate operative risk, means that surgery is viewed as the best option in many cases. In a series of 53 cases of staphylococcal endocarditis from a national endocarditis survey, those risk factors which influenced outcome were analysed. Thirty out of 53 patients had predisposing heart disease. Mortality was 39.6%. Statistical analysis revealed that attributable mortality was significantly associated with skin infection, systemic embolisation, and inappropriate therapy. Interestingly, surgical treatment was associated with better outcome.

Staphylococci in cattle and buffaloes with mastitis in Dakahlia Governorate, Egypt

“…It is used by the food-processing industry as a starter culture for meat fermentation (Resch et al, 2008). Although this bacterium is normally not associated with human infections (Otto, 2004), it has been isolated from some cases of endocarditis (Hricak et al, 1999), pyelonephritis (Tselenis-Kotsowilis et al, 1982), urinary tract infections (Orrett and Shurland, 1998), and corneal infections (Pinna et al, 1999). Additionally, some isolates of S. xylosus have virulence genes such as the one encoding elastase, which cleaves human IgA and IgG (Bedidi-Madani et al, 1998).…”

Koyun Kırkımı Sırasında İnsanlara Bulaşabilecek Bakteriler ve Antibiyotik Dirençlilik Profillerinin Belirlenmesi

“…Benzer şekilde Staphylococcus xylosus'da birçok endokardit, üriner sistem enfeksiyonları vb. enfeksiyonlardan izole edilmiştir [19,28]. Aynı zamanda S. xylosus izolatlarının çoğu, nalidiksik asit, novobiocin ve penisilline karşı dirençli bulunmuşlardır [38].…”