Epidemiology of Coagulase‐Negative Staphylococci and Infections Caused by These Organisms

Rogers, Kathie L.; Fey, Paul D.; Rupp, Mark E.

doi:10.1002/9781444308464.ch15

Cited by 6 publications

(5 citation statements)

References 318 publications

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“…In the CoNS group, S. epidermidis is the most frequently isolated nosocomial pathogen associated with bacteremia, postoperative wounds, infection due to peripheral and central venous catheters, prosthetic valves, and other indwelling medical devices. 4 5 Various other CoNS have also been implicated in blood stream infections (BSI), including S. haemolyticus , S. hominis , S. lugdunensis , S. schleiferi , S. simulans , S. capitis , and S. warneri . 6 7 Therefore, the present study was designed to determine the spectrum of pathogens causing BSI in neonates admitted in NICU of a tertiary care center in the city of Varanasi, with special reference to proportion and antimicrobial susceptibility profile of CoNS.…”

Section: Introductionmentioning

confidence: 99%

Coagulase-Negative Staphylococci in Neonatal Blood: How Concerning?

et al. 2023

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Objective Coagulase-negative staphylococci (CoNS) are being implicated as one of the leading causes of bloodstream infection (BSI). To study the spectrum, prevalence, and antimicrobial susceptibility of CoNS causing BSI in neonates. Materials and Methods A cross-sectional study was done in level III neonatal intensive care unit (NICU). Blood samples in automated culture bottles were processed as per the standard technique. Previously validated methods were followed for the characterization of CoNS and for AST of standard antibiotics by Kirby Bauer disk diffusion and vancomycin by agar dilution. The prevalence of causative organisms and susceptibility of CoNS were statistically analyzed. Categorical variables were compared by chi-square or Fisher's exact probability tests. Result In total, 1,365 blood samples (1,365 neonates) were studied, of which 383 (28.05%) were positive and 982 (71.94%) were negative. Gram-positive organisms (GPC) predominated (n = 238; 62.14%) (p < 0.001) with 41.77% (160/383) S. aureus and 13.83% (53/383) CoNS. CoNS included S. epidermidis (19, 38%), S. haemolyticus (7, 14%), S. hominis (6, 12%), S. simulans (6,12%), S. capitis (5,10%), S. cohnii (4, 8%), S. warneri (1, 2%), and S. xylosus (1, 2%). The susceptibility to netilmicin, linezolid, and vancomycin was 100% (p ≤ 0.001), and 54% (n = 27) had vancomycin MIC of 0.125 μg/mL but methicillin-resistant CoNS (MRCoNS) was 70%. Methicillin-susceptible (MS) CoNS had lower MIC of vancomycin (p < 0.05) than MRCoNS. Conclusion The spectrum of pathogens causing BSI in neonates is changing with predominance of GPC and among CoNS, S. epidermidis. Considerable proportion of MRCoNS with the emergence of MIC creep for vancomycin requires immediate attention.

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Section: Introductionmentioning

confidence: 99%

Coagulase-Negative Staphylococci in Neonatal Blood: How Concerning?

et al. 2023

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“…[2][3] This bacterium is now a leading cause of biomedical device-associated infections due to its propensity to form robust biofilms on abiotic surfaces. [3][4][5][6][7][8] This biofilm lifestyle, combined with its increasing antibiotic resistance, makes treating S. epidermidis infections with traditional antibacterial drugs difficult. 2-3, 6, 9-11 Playing an important role in the pathogenesis of S. epidermidis infections is the accessory gene regulator (agr) system, 12-17 a cell-cell communication system that allows the bacteria to sense population density and coordinate gene expression at high cell numbers to initiate group behaviors.…”

Section: Introductionmentioning

confidence: 99%

Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency

et al. 2019

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We report the solution-phase structures of native signal peptides and related analogs capable of either strongly agonizing or antagonizing the AgrC quorum sensing (QS) receptor in the emerging pathogen Staphylococcus epidermidis. Chronic S. epidermidis infections are often recalcitrant to traditional therapies due to antibiotic resistance and formation of robust biofilms. The accessory gene regulator (agr) QS system plays an important role in biofilm formation in this opportunistic pathogen, and the binding of an autoinducing peptide (AIP) signal to its cognate transmembrane receptor (AgrC) is responsible for controlling agr. Small molecules or peptides capable of modulating this binding event are of significant interest as probes to investigate both the agr system and QS as a potential antivirulence target. We used NMR spectroscopy to characterize the structures of the three native S. epidermidis AIP signals and five non-native analogs with distinct activity profiles in the AgrC-I receptor from S. epidermidis. These studies revealed a suite of structural motifs critical for ligand activity. Interestingly, a unique β-turn was present in the macrocycles of the two most potent AgrC-I modulators-in both an agonist and an antagonistthat was distinct from the macrocycle conformation in the less-potent AgrC-I modulators and in the native AIP-I itself. This previously unknown β-turn provides a structural rationale for these ligands' respective biological activity profiles. Development of analogs to reinforce the β-turn resulted in our first antagonist with subnanomolar potency in AgrC-I, while analogs designed to contain a disrupted β-turn were dramatically less potent relative to their parent compounds. Collectively, these studies provide new insights into the AIP:AgrC interactions crucial for QS activation in S. epidermidis and advance the understanding of QS at the molecular level.

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“…Bakteri Staphylococcus epidermis ini secara alami hidup di membran kulit dan membran mukosa pada manusia. Menurut (Otto, 2012) bakteri Staphylococcus epidermidis umumnya telah resisten terhadap antibiotik penisilin dan metisilin, sedangkan penelitian yang dilakukan oleh Rogers et al, (2009) (Tacconelli et al, 2018).…”

Section: Pendahuluanunclassified

Uji Aktivitas Antibakteri Ekstrak Etanol Daun Suruhan (Peperomia Pellucida L.Kunth) Terhadap Bakteri Staphylococcus Aureus dan Staphylococcus Epidermidis

Herdiansyah,

Bariun,

Dewi

2023

jpmw

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Jerawat sering terjadi dikarenakan bakteri Staphylococcus aureus dan Staphylococcus epidermidis. Tujuan penelitian ini adalah untuk mengetahui aktivitas ekstrak daun suruhan (Peperomia pellucida L.Kunth) terhadap pertumbuhan bakteri Staphylococcus aureus dan Staphylococcus epidermis. Penelitian ini merupakan penelitian analitik dengan menggunakan sampel daun suruhan (Peperomia pellucida L.Kunth) yang diekstraksi dengan metode maserasi menggunakan pelarut etanol 96% dipekatkan dalam rotary evaporator hingga mendapatkan ekstrak yang kental. Selanjutnya pengujian aktivitas antibakteri ekstrak etanol daun suruhan (Peperomia pellucida L.Kunth) dengan konsentrasi 20%, 25% dan 30% serta negatife (DMSO) dan positif (klindamisin®) yang dibuat 3 replikasi dilakukan dengan metode paper disk. Analisis data menggunakan SPSS one-way ANOVA dan dilanjutkan dengan uji LSD. Hasil penelitian penunjukan bahwa ekstrak daun suruhan (Peperomia pellucida L.Kunth) memiliki aktivitas bakteri terhadap Staphylococcus aureus dan Staphylococcus epidermidis pada konsentrasi 20%,25% dan 30% dengan kategori lemah < 5 mm, untuk bakteri Staphylococcus aureus dan untuk bakteri Staphylococcus epidermidis memiliki kategori sedang dengan nilai 5-10 mm. Untuk uji LSD memiliki perbedanaan antara sampel ekstrak daun suruhan (Peperomoa pellucida L.Kunth) dengan konsentrasi 20%,25% dan 30% dengan kontrol positif (klindamisin), dimana sampel daun suruhan (peperomia pellucida L.Kunth) dengan konsentrasi 20%,25% dan 30% memiliki hasil berbeda signifikan sedangkan kontrol positif (klindamisin) memiliki hasil signifikan.

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Epidemiology of Coagulase‐Negative Staphylococci and Infections Caused by These Organisms

Cited by 6 publications

References 318 publications

Coagulase-Negative Staphylococci in Neonatal Blood: How Concerning?

Coagulase-Negative Staphylococci in Neonatal Blood: How Concerning?

Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency

Uji Aktivitas Antibakteri Ekstrak Etanol Daun Suruhan (Peperomia Pellucida L.Kunth) Terhadap Bakteri Staphylococcus Aureus dan Staphylococcus Epidermidis

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