Aetiology of Acute Gastro-Enteritis in Children at Saint Camille Medical Centre, Ouagadougou, Burkina Faso

Simporé, Jacques; Ouermi, Djénèba; Ilboudo, D.; Kabre, A; Zeba, Boukaré; Pietra, Virginio; Pignatelli, S.; Nikiema, Jean‐Baptiste; Kabré, Gustave B.; Caligaris, Silvio; Schumacher, Fabian; Castelli, Francesco

doi:10.3923/pjbs.2009.258.263

Cited by 29 publications

(31 citation statements)

References 24 publications

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“…Yersiniosis is the third most frequent bacterial disease causing human enteric infections in Europe [10], but reports of this disease are extremely infrequent in developing countries. In West Africa, only few countries reported the isolation of Yersinia from clinical cases [11–20], most likely because an active search for these bacteria is not performed. This is supported by the observation that in Nigeria, where studies were carried out to specifically look for this pathogen in human and animal samples, Yersinia strains were isolated [15–19].…”

Section: Discussionmentioning

confidence: 99%

“…enterocolitica represents the third cause of bacterial diarrhea in Europe, after campylobacteriosis and salmonellosis [10] reports of human yersiniosis are scarce in West Africa. A systematic survey of children with diarrhea in Ouagadougou (Burkina Faso) allowed the isolation of Yersinia strains from 1.7% of the stools tested [11]. However, no indication of the species or biotype of the strains was provided, making difficult to estimate whether these isolates corresponded to saprophytic or pathogenic species.…”

Section: Introductionmentioning

confidence: 99%

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Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

et al. 2017

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BackgroundEnteropathogenic Yersinia circulate in the pig reservoir and are the third bacterial cause of human gastrointestinal infections in Europe. In West Africa, reports of human yersiniosis are rare. This study was conducted to determine whether pathogenic Yersinia are circulating in pig farms and are responsible for human infections in the Abidjan District.Methodology/Principal findingsFrom June 2012 to December 2013, pig feces were collected monthly in 41 swine farms of the Abidjan district. Of the 781 samples collected, 19 Yersinia strains were isolated in 3 farms: 7 non-pathogenic Yersinia intermedia and 12 pathogenic Yersinia enterocolitica bioserotype 4/O:3. Farm animals other than pigs and wild animals were not found infected. Furthermore, 2 Y. enterocolitica 4/O:3 strains were isolated from 426 fecal samples of patients with digestive disorders. All 14 Y. enterocolitica strains shared the same PFGE and MLVA profile, indicating their close genetic relationship. However, while 6 of them displayed the usual phage type VIII, the other 8 had the highly infrequent phage type XI. Whole genome sequencing and SNP analysis of individual colonies revealed that phage type XI strains had unusually high rates of mutations. These strains displayed a hypermutator phenotype that was attributable to a large deletion in the mutS gene involved in DNA mismatch repair.Conclusions/SignificanceThis study demonstrates that pathogenic Y. enterocolitica circulate in the pig reservoir in Côte d'Ivoire and cause human infections with a prevalence comparable to that of many developed countries. The paucity of reports of yersiniosis in West Africa is most likely attributable to a lack of active detection rather than to an absence of the microorganism. The identification of hypermutator strains in pigs and humans is of concern as these strains can rapidly acquire selective advantages that may increase their fitness, pathogenicity or resistance to commonly used treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

et al. 2017

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“…But we have no statistical data indicating that these dead children have died from malnutrition. In addition we know that other studies have shown that, among malnourished children, some had viral infections (rotavirus, adenovirus, HIV) [17], bacterial and parasitic infections that cause diarrhea and dehydration, leading them to death. …”

Section: Discussionmentioning

confidence: 99%

Effects of a Cereal and Soy Dietary Formula on Rehabilitation of Undernourished Children at Ouagadougou, in Burkina Faso

Douamba

Martinetto²,

Pietra

et al. 2012

Journal of Nutrition and Metabolism

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The New Misola consists of millet soybean, peanut, vitamins, minerals, and industrial amylase. Our objective is to demonstrate that porridge made from local grains and legumes restores the nutritional balance of malnourished children. The study was carried on 304 malnourished children aged 6–48 months including 172 girls and 132 boys from Saint Camille Medical Centre. At the beginning, these malnourished children had a WHZ z-score of −3.10 and a WAZ z-score of −3.85, which reflected, according to WHO, a severe malnutrition. After eight weeks of nutritional rehabilitation, a normal WHZ of −1.41 was obtained. These children recovered more than those in a similar study performed in 2006 with the old formula of Misola. This study shows that malnutrition remains a public health problem in Burkina Faso. It should be necessary that public health services and the epidemiologists work in synergy with nutritionists and “nutrigenetics” in order to combat malnutrition efficiently.

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“…Epidemiological studies of adenovirus in infants and children with acute gastroenteritis have shown its importance in both developed and developing countries (6,10,11,17,18,23,31,39,43,49). Next to rotavirus, enteric adenovirus has been shown to be the most common cause of pediatric viral gastroenteritis in Kolkata (31).…”

Section: Discussionmentioning

confidence: 99%

Circulation of a Novel Pattern of Infections by Enteric Adenovirus Serotype 41 among Children below 5 Years of Age in Kolkata, India

et al. 2011

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Aetiology of Acute Gastro-Enteritis in Children at Saint Camille Medical Centre, Ouagadougou, Burkina Faso

Cited by 29 publications

References 24 publications

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

Effects of a Cereal and Soy Dietary Formula on Rehabilitation of Undernourished Children at Ouagadougou, in Burkina Faso

Circulation of a Novel Pattern of Infections by Enteric Adenovirus Serotype 41 among Children below 5 Years of Age in Kolkata, India

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