Aetiology of osteochondritis dissecans. Failure to establish a familial background

Petrie, P. W. R.

doi:10.1302/0301-620x.59b3.893517

Cited by 95 publications

(31 citation statements)

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“…In our situation, both twins presented with OCD of the left side and one twin presented with a bilateral occurrence. Our findings support those of Petrie [17], who also suggested genetics play a role in the formation of OCD. However, in that paper and our study, genetic causation could not be established.…”

Section: Discussionsupporting

confidence: 92%

Case Report: Osteochondritis Dissecans in Twins

Mackie

Wilkins

2010

Clinical Orthopaedics &Amp; Related Research

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Osteochondritis dissecans is a lesion of subchondral bone with subsequent involvement of the overlying cartilage. Although the etiology of the disease is unknown, mechanical, traumatic, and ischemic etiologies have been suggested, in addition to developmental and genetic factors. There are several treatment options depending on the stage of the disease and surgeon preference. The use of a fresh osteochondral allograft for treatment of a lesion of the femoral condyle is relatively new, and we report its use in a unique situation involving identical twins who both presented with osteochondritis dissecans of the same anatomic location within 2 years of each other. Since these were identical lesions in identical twins, this commonality supports the suggestion that some genetic component may be present in the etiology, especially in this situation where a genetic connection existed. We recommend genetic studies to determine the extent of genetic influence on the disease.

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Section: Discussionsupporting

confidence: 92%

Case Report: Osteochondritis Dissecans in Twins

Mackie

Wilkins

2010

Clinical Orthopaedics &Amp; Related Research

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“…An autosomal-dominant inheritance pattern is espoused by at least two separate authors [58,68]. However, disputing the evidence of familial inheritance, Petrie [67] reported on a radiographic examination of first-degree relatives and discovered only 1.2% with an OCD. Although genetics may still play a role, the association remains elusive.…”

Section: Etiologymentioning

confidence: 99%

A Review of Knowledge in Osteochondritis Dissecans: 123 Years of Minimal Evolution from König to the ROCK Study Group

Edmonds

Polousky

2013

Clinical Orthopaedics &Amp; Related Research

215

223

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Background Osteochondritis dissecans (OCD) was first described to provide an explanation for the nontraumatic development of loose bodies within a joint. Despite many reports on the subject, there remains no clear understanding of the etiology, natural history, or treatment. Questions/purposes This review was undertaken to delineate (1) the etiology of OCD; (2) the presentation and locations; (3) the most appropriate imaging modalities; and (4) the most effective treatment strategies. Methods We reviewed the English literature using a database compiled from a Medline search for ''osteochondritis dissecans''. We identified 1716 publications, 1246 of which were in English. After exclusions, we reviewed 748 articles and of these cited 85. The observations of each study were then synthesized into this report. Results There appears to be no consensus concerning the etiology of OCD lesions. The presentations and locations are variable, but the knee, ankle, and elbow are most commonly involved. Although plain film assessment is important in OCD, there appears to be a trend toward the use of MRI, but the preferred sequences are in evolution. We found no consensus on the treatment of these lesions, related in part to the lack of agreement of methods for assessing outcomes. Conclusions Despite more than a century of study, we have made little advancement in our understanding of OCD. A study group has been formed to address this issue and actively seeks to answer these unknown issues regarding OCD.

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“…Although Petrie first concluded that OCD does not have a familial association in 1977, multiple case reports have been published since then that demonstrate a potentially heritable genetic component to the etiology of OCD [20]. Specifically, many of these recent case reports have described OCD lesions in sets of monozygotic twins, including some in which the appearance of the lesions themselves is identical [5,9,15,17,19,21].…”

Section: Introductionmentioning

confidence: 99%