Aetiology of Steatorrhoea

Frazer, A. C.

doi:10.1136/bmj.2.4529.641

Cited by 23 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frazer and Sammons (4) noted that lipids isolated from the lumen of the intestinal tract of rats had a high hydroxyl value and concluded that monoglyceride was present. Later Frazer (5) reported, without presenting experimental details, that he had found monoglycerides in the intestinal tracts of human subjects. The formation and presence of monoglycerides in the intestinal tract during the digestion of fat has been reported in the dog (6), rat (3,4,(7)(8)(9), cat (10), monkey (8), and man (5,11).…”

mentioning

confidence: 99%

Digestion of Neutral Fats by Human Subjects 1

Harris¹,

Chamberlain²,

Benedict³

1955

J. Clin. Invest.

View full text Add to dashboard Cite

Several theories have been advanced to describe the digestion of fats in animals and in humans. Of these, two have been popular. The hydrolytic theory (1) suggests that triglycerides are broken down completely to fatty acids and glycerol which are then absorbed into the intestinal wall. The particulate theory (2) suggests that triglycerides are partially hydrolyzed in the intestinal lumen to monoglycerides, diglycerides, and fatty acids. The partial glycerides, fatty acids, and bile salts cause a fine emulsification of the remaining triglyceride. This emulsion, containing triglycerides, then enters the intestinal wall.Much indirect evidence exists for the formation of partial glycerides during fat digestion. Reiser, Bryson, Carr, and Kuiken (3) analyzed the lipids recovered from the thoracic ducts of rats fed tagged triglyceride and concluded that the major portion of ingested fat is hydrolyzed to monoglyceride prior to absorption. Frazer and Sammons (4) noted that lipids isolated from the lumen of the intestinal tract of rats had a high hydroxyl value and concluded that monoglyceride was present. Later Frazer (5) reported, without presenting experimental details, that he had found monoglycerides in the intestinal tracts of human subjects. The formation and presence of monoglycerides in the intestinal tract during the digestion of fat has been reported in the dog (6), rat (3, 4, 7-9), cat (10), monkey (8), and man (5, 11).Theoretically the formation of two isomeric monoglycerides is possible when a triglyceride is digested to monoglyceride. It was not until the recent work of Mattson, Benedict, Martin, and Beck (7) that 2-monoglycerides were shown to 1

show abstract

mentioning

confidence: 99%

Digestion of Neutral Fats by Human Subjects 1

Harris¹,

Chamberlain²,

Benedict³

1955

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…to suppose that the vitamin-B deficiency is intimately related to the aetiology of the fat-absorption defect (Frazer, 1947).…”

mentioning

confidence: 99%

A New Mechanism of Vitamin Deprivation

Ac¹

1949

BMJ

Self Cite

View full text Add to dashboard Cite

“…Faulty utilization of vitamin A has been described in cases of alcoholic cirrhosis (Patek and Haig, 1939). Faulty phosphorylation was thought to account for certain riboflavin deficiencies (Verzar and Laszt, 1936), but the relationship of this deficiency to the adrenal cortex has not been substantiated (Nelson, 1940;Ferrebee, 1940 (Howe, 1920;Hess and Abramson, 1931 to suppose that the vitamin-B deficiency is intimately related to the aetiology of the fat-absorption defect (Frazer, 1947 This competition hypothesis would account for the exacerbation of vitamin deficiencies and diarrhoea associated with heavy growth and high-level invasion of intestinal bacteria. This bacterial invasion may be related to fixation of pH as a result of achlorhydria, and possibly the presence of suitable food materials due to delayed absorption.…”

mentioning

confidence: 99%