Afebrile Benign Convulsion Associated With Mild Gastroenteritis

Abstract

Background:Benign convulsion with mild gastroenteritis is a new clinical entity that occurs in children who are otherwise healthy.Method:This cohort study held among patients with afebrile convulsion and accompanying gastroenteritis in a tertiary children hospital during a 2-year period. Demographic and clinical data were analyzed. Neurodevelopmental milestones were observed during a follow-up period of 12 to 24 months.Results:Twenty-five patients aged 3 to 48 months with female predominance were enrolled. Ninety-three percent of cases experienced generalized tonic-clonic seizures. One-third of seizures occurred in clusters. Primary laboratory findings and electroencephalography were normal except for 3 with few epileptic waves. During the follow-up period, no seizure recurrence happened. Long-term antiepileptic treatment was unnecessary.Conclusion:Afebrile convulsion accompanying mild gastroenteritis is a convulsive disorder with reassuring prognosis. Due to its benign course, comprehensive neurodiagnostic evaluation and long-term antiepileptic drugs are usually avoidable.

Clinical Implications of Ketosis in Children with Benign Convulsions with Mild Gastroenteritis

“…As reported previously, repetitive seizures are a unique characteristic of CwG, with a reported prevalence of 33-75% among these patients. [19][20][21] The current results indicate that severe ketosis is not significantly associated with seizure recurrence in the ED in comparison with nonsevere ketosis (53.3% vs. 37.0%, p=0.307), or with the risk of such recurrence (OR= 1.943, p=0.309). Although ketosis during a ketogenic diet achieves seizure reduction in children with refractory epilepsy, it is unknown whether elevated ketones directly inhibit seizures.…”

Clinical characteristics, treatment, and long-term outcomes in children suffering from benign convulsions with mild gastroenteritis: a retrospective study

“…All children showed normal psychomotor development. Therefore, prescription of long-term antiepileptics is not recommended [ 12 ].…”

“…BCWG seizures are often clustered, with generalized tonic-clonic seizures forming the most common type of seizure cluster, although focal or secondary generalized seizures are also observed [ 7 , 12 , 15 ]. Consistent with previous reports, we found that tonic or generalized tonic-clonic seizures were the most common types of seizures associated with BCWG; however, it is very likely that BCWG originated as a focal event as spikes were observed in the EEG tests that were localized to various regions of the cortex.…”

Comparison of clinical characteristics between cluster and isolated seizures associated with benign convulsions with mild gastroenteritis

“…[2] Interestingly, cluster seizures are also highly frequent in benign convulsions with mild gastroenteritis (CWG), which is a common cause of afebrile convulsions in children. [3] According to previous studies, Cluster seizures were observed in 13%-75% of patients with CWG. [4][5][6] With the absence of a previous history of convulsions in children with CWG, cluster seizures early in the course of this disease can easily cause anxiety in the family.…”