Afferent connections of the nucleus accumbens with the amygdaloid body and the dopaminergic mesencephalic formations of the cat brain

Gorbachevskaya, A. I.

doi:10.1007/bf01185947

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…McDonald (1991) clarified the topographic organization of rat amygdalostriatal projections in partial agreement with earlier suggestions (Gorbachevskaya, 1990, 1991; Groenewegen et al, 1980; Kelley et al, 1982; Kita and Kitai, 1990; Krettek and Price, 1978; Russchen et al, 1985). First, a rostral–caudal topography indicates that the rostral two-thirds of the BLA projects to the dorsal stri- atum, but the most caudal BLA does not; instead, the caudal BLA selectively innervates the medial NAc (McDonald, 1991).…”

Section: Cortical-like Topographic Projection Of Basal Amygdala Tsupporting

confidence: 88%

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Zorrilla

Koob

2013

Neuroscience & Biobehavioral Reviews

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In MacLean’s triune brain, the amygdala putatively subserves motivated behavior by modulating the “reptilian” basal ganglia. Accordingly, Ann Kelley, with Domesick and Nauta, influentially showed that amygdalostriatal projections are much more extensive than were appreciated. Caudal of the anterior commissure, the entire striatum receives afferents from deep basal nuclei of the amygdala. They highlighted that amygdalar projections to the rostral ventromedial striatum converged with projections from the ventral tegmental area and cingulate cortex, forming a “limbic striatum”. Orthologous topographic projections subsequently were observed in fish, amphibians, and reptiles. Subsequent functional studies linked acquired value to action via this neuroanatomical substrate. From Dr. Kelley’s work evolved insights into components of the distributed, interconnected network that subserves motivated behavior, including the nucleus accumbens shell and core and the striatal-like extended amygdala macrostructure. These heuristic frameworks provide a neuroanatomical basis for adaptively translating motivation into behavior. The ancient amygdala-to-striatum pathways remain a current functional thread not only for stimulus–response valuation, but also for the psychopathological plasticity that underlies addictionrelated memory, craving and relapse.

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Section: Cortical-like Topographic Projection Of Basal Amygdala Tsupporting

confidence: 88%

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Zorrilla

Koob

2013

Neuroscience & Biobehavioral Reviews

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“…For fibertracts connecting the NAc to the VTA in the present study we could not identify a morphological correlate in the current fiber-dissectionstudies. However, MacNiven, Leong, and Knutson (2020) described two similar main fiber connections, which they refer to as inferior and superior NAc-VTA tract in their DWI-and tractography-based structural analysis of the medial forebrain bundle and results from numerous tract-tracing-studies also confirmed this particular pathway (Beckstead, Domesick, & Nauta, 1979;Gorbachevskaya, 1991;Herkenham, Edley, & Stuart, 1984;Zahm & Heimer, 1993). Moreover, Coenen et al had entirely characterized the medial forebrain bundle (MFB) for the human brain using MRI and global fiber-tracking (Coenen et al, 2018).…”

Section: Anatomical Validation Of Fiber-connectionsmentioning

confidence: 99%

Nucleus accumbens projections: Validity and reliability of fiber reconstructions based on high‐resolution diffusion‐weighted MRI

Rusche

Kaufmann

Voges

2021

Human Brain Mapping

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Clinical effects of deep brain stimulation are largely mediated by the activation of myelinated axons. Hence, increasing attention has been paid in the past on targeting white matter tracts in addition to gray matter. Aims of the present study were:(i) visualization of discrete afferences and efferences of the nucleus accumbens (NAc), supposed to be a major hub of neural networks relating to mental disorders, using probabilistic fiber tractography and a data driven approach, and (ii) validation of the applied methodology for standardized routine clinical applications. MR-data from 11 healthy subjects and 7 measurement sessions each were acquired on a 3T MRIscanner. For probabilistic fiber tracking the NAc as a seed region and the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), amygdala (AMY), hippocampus (HPC), dorsomedial thalamus (dmT) and ventral tegmental area (VTA) as target regions were segmented for each subject and both hemispheres. To quantitatively assess the reliability and stability of the reconstructions, we filtered and clustered the

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“…Autoradiography [6,7] has been used to study the organization of the descending connections of the central part of the AB with brainstem structures [4], particularly the midbrain reticular formation, the substantia nigra, the nucleus ruber, and the ventral part of the central gray matter. Injections of horseradish peroxidase into brain stem structures [7] (the nucleus ruber and the midbrain reticular formations) were followed by the detection of labeled neurons in the medial part of the central nucleus of the AB, with occasional neurons being found in the magnocellular part of the basal nucleus.…”

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confidence: 99%

Structural organization of the thoracic nucleus of the spinal cord of the cat after destruction of the amygdaloid body of the brain

Flegontova

1999

Neurosci Behav Physiol

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The amygdaloid body (AB) of the brain has long been of interest as a structure which in anatomical and functional terms occupies an intermediate position between the neocortex and subcortical formations [9], as a part of the limbic system with integrative and modulating influences on a number of basic body functions [5, 11,15,16]. Autoradiography [6,7] has been used to study the organization of the descending connections of the central part of the AB with brainstem structures [4], particularly the midbrain reticular formation, the substantia nigra, the nucleus ruber, and the ventral part of the central gray matter. Injections of horseradish peroxidase into brain stem structures [7] (the nucleus ruber and the midbrain reticular formations) were followed by the detection of labeled neurons in the medial part of the central nucleus of the AB, with occasional neurons being found in the magnocellular part of the basal nucleus. After injection of horseradish peroxidase into the substantia gelatinosa of the posterior horn of the first cervical segment of the spinal cord, only occasional labeled neurons were seen in the medial part of the central nucleus of the AB [6].Analysis of published data [7,8] leads to the conclusion that the structural and functional connections of the AB with brain and, particularly, spinal cord formations have received inadequate study [11]. The connections of the AB with sensory centers of the spinal cord (including the thoracic nucleus) have not been the subject of direct investigations in humans or animals [13,14].

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Afferent connections of the nucleus accumbens with the amygdaloid body and the dopaminergic mesencephalic formations of the cat brain

Cited by 3 publications

References 6 publications

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Nucleus accumbens projections: Validity and reliability of fiber reconstructions based on high‐resolution diffusion‐weighted MRI

Structural organization of the thoracic nucleus of the spinal cord of the cat after destruction of the amygdaloid body of the brain

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