Afferent connections of the thalamic paraventricular and parataenial nuclei in the rat — a retrograde tracing study with iontophoretic application of Fluoro-Gold

Chen, Sheng; Su, Hong-Sen

doi:10.1016/0006-8993(90)91570-7

Cited by 113 publications

(98 citation statements)

References 24 publications

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“…Laterally, labeling was further modest in the centrolateral, laterodorsal, ventrolateral, ventromedial, and parafascicular nuclei, as well as in the posterior thalamic nuclear group and zona incerta. These results are generally consistent with previous findings of direct projections from the anterior claustrum to both the submedius thalamic nucleus (Yoshida et al, 1992) and many other thalamic nuclei (Groenewegen, 1988;Chen and Su, 1990).…”

Section: Efferent Connections Of the Anterior Claustrumsupporting

confidence: 83%

“…These discrepancies could be explained by differences in the tract-tracing properties of FG as compared with Fast Blue or Diamidino Yellow. That is, injections of both Fast Blue and Diamidino Yellow usually produce tissue damage in the injection site (Schmued and Fallon, 1986;Sloniewski et al, 1986a), so that the tracers can be taken up by damaged fibers of passage (Schmued and Fallon, 1986), whereas FG appears not to be taken up by fibers of passage at the ejection site, as shown by the present results (see control ejections below) as well as previous studies (Schmued and Fallon, 1986;Pieribone and Aston-Jones, 1988;Chen and Su, 1990;Moga and Moore, 1997). In addition, FG does not leak out of labeled cells (Schmued and Fallon, 1986) and thus differs from Fast Blue and Diamidino Yellow, which can diffuse out of labeled cells (Schmued and Fallon, 1986).…”

Section: Afferent Connections Of the Anterior Claustrumsupporting

confidence: 77%

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Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

et al. 2001

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The claustrum has been implicated in the kindling of generalized seizures from limbic sites. We examined the susceptibility of the anterior claustrum itself to kindling and correlated this with an anatomical investigation of its afferent and efferent connections.Electrical stimulation of the anterior claustrum resulted in a pattern of rapid kindling with two distinct phases. Early kindling involved extremely rapid progression to bilaterally generalized seizures of short duration. With repeated daily kindling stimulations, early-phase generalized seizures abruptly became more elaborate and prolonged, resembling limbic-type seizures as triggered from the amygdala. We suggest that the rapid rate of kindling from the anterior claustrum is an indication that the claustrum is functionally close to the mechanisms of seizure generalization.In support of our hypothesis, we found significant afferent, efferent, and often reciprocal connections between the anterior claustrum and areas that have been implicated in the generation of generalized seizures, including frontal and motor cortex, limbic cortex, amygdala, and endopiriform nucleus. Additional connections were found with various other structures, including olfactory areas, nucleus accumbens, midline thalamus, and brainstem nuclei including the substantia nigra and the dorsal raphe nucleus. The anatomical connections of the anterior claustrum are consistent with its very high susceptibility to kindling and support the view that the claustrum is part of a forebrain network of structures participating in the generalization of seizures.

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Section: Efferent Connections Of the Anterior Claustrumsupporting

confidence: 83%

Section: Afferent Connections Of the Anterior Claustrumsupporting

confidence: 77%

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

et al. 2001

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“…The lamina terminalis is now well established as a primary site for osmoreception in the brain (12,36,37,55,69,70). Furthermore, based on injections of tracers in the OVLT but not restricted to it, there appear to be efferent connections from the region to the dorsal midline of the thalamus (4,10,14,15,23,61). The present study provides functional evidence, in the form of Fos labeling following osmotic challenges, that the OVLT relays osmotic signals directly to the dorsal midline of the thalamus, which contains the paraventricular and medial part of the dorsomedial thalamic nucleus.…”

Section: Discussionmentioning

confidence: 99%

“…, periaqueductal gray (33), and thalamus (10,50), suggesting that the lamina terminalis may be important for physiological responses to osmotic signals other than neuroendocrine regulation. Thirst has been described as a homeostatic or primal emotion (16,19) whereby inner feelings (e.g., urge to breathe, hunger, thirst, desire for sleep, fatigue) provide motivating emotions essential for survival.…”

mentioning

confidence: 99%

The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst

Hollis¹,

McKinley²,

D'Souza³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst. Am J Physiol Regul Integr Comp Physiol 294: R1390-R1401, 2008. First published January 30, 2008 doi:10.1152/ajpregu.00869.2007The pathways involved in the emotional aspects of thirst, the arousal and affect associated with the generation of thirst and the motivation to obtain satiation, have been studied but remain poorly understood. Rats were therefore injected with the neurotropic virus pseudorabies in either the insular or cingulate cortex. After 2 days of infection, pseudorabies-positive neurons were identified within the thalamus and lamina terminalis. In a separate group of rats, the retrograde tracer cholera toxin subunit b (CTb) was used in combination with either isotonic (0.15 M NaCl) or hypertonic (0.8 M NaCl) saline (1 ml/100 g body wt ip). Rats injected with CTb in the insular cortex and stimulated with hypertonic saline had increased numbers of Fos/CTb double-positive neurons in the paraventricular, rhomboid, and reuniens thalamic nuclei, whereas those rats injected with CTb in the cingulate cortex and challenged with hypertonic saline had increased numbers of Fos/CTb double-positive neurons in the medial part of the mediodorsal, interanteromedial, anteromedial, and ventrolateral part of the laterodorsal thalamic nuclei. Rats injected with CTb in the dorsal midline of the thalamus and challenged with hypertonic saline had increased numbers of Fos/CTb double-positive neurons within the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus, and insular cortex but not the subfornical organ. A small proportion of the CTb-positive neurons in the OVLT were immunopositive for transient receptor potential vanilloid 1, a putative osmoresponsive membrane protein. These results identify functional thalamocortical pathways involved in relaying osmotic signals to the insular and cingulate cortex and may provide a neuroanatomical framework for the emotional aspects of thirst. organum vasculosum; subfornical organ; hypertonic saline; pseudorabies; cholera toxin THE LAMINA TERMINALIS, which contains the organum vasculosum of the lamina terminalis (OVLT), subfornical organ, and median preoptic nucleus, relays osmotic and endocrine signals to the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus to regulate vasopressin secretion (36,38,44,45,55,64,69,70). Putative osmoresponsive membrane proteins expressed within the lamina terminalis, transient receptor potential vanilloid (TRPV) 1 and TRPV4, are important for osmoreception and subsequent vasopressin secretion following hyperosmotic stimulation (12,30,31,59). The lamina terminalis contains efferent projections to regions other than the PVN and SON (34,39,46), including the lateral hypothalamus (4), periaqueductal gray (33), and thalamus (10, 50), suggesting that the lamina terminalis may be important for physiological responses to osmotic signals other than neuroendocr...

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“…In our study, the only brain region that displayed acid-induced and Ca v 3.2-dependent positive pERK staining is PVA. Retrograde tracing studies in rat (Peschanski and Besson, 1984;Chen and Su, 1990;Otake et al, 1995;Novak et al, 2000;Krout et al, 2002) show that PVA receives projections from regions that are important in generating pain perception such as ACC, CeA, parabrachial area (PB), PAG, dorsal and medial raphe nucleus, and nucleus raphe magnus (Price, 2000;Millan, 2002). Although PVA is not commonly known as the pain matrix in the brain, increased c-Fos expression and pERK staining in PVA have been reported in several pain models in rat and mouse (Bullitt, 1990;Davies et al, 1997;Gioia et al, 2001;Chung et al, 2007;Nishii et al, 2008;Zhang et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Ca_v3.2 T-Type Ca²⁺Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain

Chen

Liu²,

Chang³

et al. 2010

J. Neurosci.

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Treatments for chronic musculoskeletal pain, such as lower back pain, fibromyalgia, and myofascial pain syndrome, remain inadequate because of our poor understanding of the mechanisms that underlie these conditions. Although T-type Ca 2ϩ channels (T-channels) have been implicated in peripheral and central pain sensory pathways, their role in chronic musculoskeletal pain is still unclear. Here, we show that acid-induced chronic mechanical hyperalgesia develops in Ca v 3.1-deficient and wild-type but not in Ca v 3.2-deficient male and female mice. We also show that T-channels are required for the initiation, but not maintenance, of acid-induced chronic muscle pain. Blocking T-channels using ethosuximide prevented chronic mechanical hyperalgesia in wild-type mice when administered intraperitoneally or intracerebroventricularly, but not intramuscularly or intrathecally. Furthermore, we found an acid-induced, Ca v 3.2 T-channeldependent activation of ERK (extracellular signal-regulated kinase) in the anterior nucleus of paraventricular thalamus (PVA), and prevention of the ERK activation abolished the chronic mechanical hyperalgesia. Our findings suggest that Ca v 3.2 T-channel-dependent activation of ERK in PVA is required for the development of acid-induced chronic mechanical hyperalgesia.

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Afferent connections of the thalamic paraventricular and parataenial nuclei in the rat — a retrograde tracing study with iontophoretic application of Fluoro-Gold

Cited by 113 publications

References 24 publications

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst

Ca_v3.2 T-Type Ca²⁺Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain

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Afferent connections of the thalamic paraventricular and parataenial nuclei in the rat — a retrograde tracing study with iontophoretic application of Fluoro-Gold

Cited by 113 publications

References 24 publications

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst

Cav3.2 T-Type Ca2+Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain

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Ca_v3.2 T-Type Ca²⁺Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain