Afferents to the medial nucleus of the trapezoid body and their collateral projections

Kuwabara, N.; DiCaprio, Ralph A.; Zook, John M.

doi:10.1002/cne.903140405

Cited by 188 publications

(158 citation statements)

References 57 publications

Supporting

Mentioning

142

Contrasting

Order By: Relevance

“…Afferent and efferent connections of the MNTB are also changing during this age (Kandler and Friauf 1993;Kim and Kandler 2003;Kuwabara et al 1991), which is the age used for patch-clamp studies. If indeed some MNTB principal cells do receive multiple calyces, it will be important to determine whether this is a transitory phenomenon during development like that seen in the other instances of strong single inputs or whether it persists in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

Bergsman¹,

Camilli²,

McCormick³

2004

Journal of Neurophysiology

View full text Add to dashboard Cite

The calyx of Held is a giant nerve terminal that forms a synapse directly onto the principal cells of the medial nucleus of the trapezoid body (MNTB) in the mammalian auditory brain stem. This central synapse, which is involved in sound localization, has become widely used for studying synaptic transmission. Anatomical studies of this nucleus have indicated that each principal cell is innervated by only one calyx. Here we use previously established electrophysiological criteria of excitatory postsynaptic current amplitude, kinetics, and transmitter type, as well as other characteristics commonly reported for this synapse, to examine the input properties of principal neurons. Our findings indicate that some principal cells receive more than one strong excitatory input. These inputs meet previously established electrophysiological criteria for identification as calyceal nerve terminals. Implications for the execution and analysis of experiments to avoid errors due to such multiple inputs are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

Bergsman¹,

Camilli²,

McCormick³

2004

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…Cant and Hyson, 1992, Spirou and Berrebi, 1997, Spirou et al, 1998; and a contralateral projection to superior paraolivary nucleus or dorsomedial periolivary nucleus that sends a GABAergic projection to the inferior colliculus (e.g. Kuwabara et al, 1991, Smith et al, 1991, Kulesza and Berrebi, 2000. Other projections to the VNLL and the ipsilateral LSO (in certain species) have been reported (Friauf and Ostwald, 1988, Kuwabara et al, 1991, Smith et al, 1991.…”

Section: Relationship To Morphological Cell Types In Cnmentioning

confidence: 98%

“…Their primary termination sites appear to be on cells in brainstem nuclei that provide inhibitory inputs to other regions. These include the large calyx of Held terminals onto glycinergic cells of the contralateral medial nucleus of the trapezoid body (MNTB) that provide inhibitory inputs to LSO and MSO cells (Glendenning et al, 1985, Kuwabara et al, 1991, Banks and Smith, 1992, Cant and Hyson, 1992, Smith et al, 1998, Chirila et al, 2007 (Kopp-Scheinpflug et al, 2008, this issue), terminals onto neurons of the ipsilateral lateral nucleus of the TB that provide inhibitory inputs to MSO cells (e.g. Cant and Hyson, 1992, Spirou and Berrebi, 1997, Spirou et al, 1998; and a contralateral projection to superior paraolivary nucleus or dorsomedial periolivary nucleus that sends a GABAergic projection to the inferior colliculus (e.g.…”

Section: Relationship To Morphological Cell Types In Cnmentioning

confidence: 99%

“…Kuwabara et al, 1991, Smith et al, 1991, Kulesza and Berrebi, 2000. Other projections to the VNLL and the ipsilateral LSO (in certain species) have been reported (Friauf and Ostwald, 1988, Kuwabara et al, 1991, Smith et al, 1991.Which neurons show enhanced phase-locking relative to the AN? The phenomenon is surprisingly common, especially at "tail frequencies".…”

mentioning

confidence: 95%

See 1 more Smart Citation

The volley theory and the spherical cell puzzle

Joris

Smith

2008

Neuroscience

View full text Add to dashboard Cite

Temporal coding in the auditory nerve is strikingly transformed in the cochlear nucleus. In contrast to fibers in the auditory nerve, some neurons in the cochlear nucleus can show "picket fence" phaselocking to low-frequency pure tones: they fire a precisely timed action potential at every cycle of the stimulus. Such synchronization enhancement and entrainment is particularly prominent in neurons with the spherical and globular morphology, described by Osen (1969). These neurons receive large axosomatic terminals from the auditory nerve -the endbulbs and modified endbulbs of Held -and project to binaural comparator nuclei in the superior olivary complex. The most popular model to account for picket fence phase-locking is monaural coincidence detection. This mechanism is plausible for globular neurons, which receive a large number of inputs. We draw attention to the existence of enhanced phase-locking and entrainment in spherical neurons, which receive too few endbulb inputs from the auditory nerve to make a coincidence detection of endbulb firings a plausible mechanism of synchronization enhancement.Keywords temporal coding; binaural; synchronization; amplitude modulation; cochlear nucleus; jitter Biological taxonomy is always fraught with splitting vs. lumping difficulties. Kirsten Osen's morphological parcellation of the cochlear nucleus (CN) (Osen, 1969) was a landmark achievement because it hit exactly the right level along the splitter-lumper dimension. Her parcellation proved to dovetail very well with the physiological parcellation of response categories based on responses to short tone bursts (Kiang et al., 1965a, Pfeiffer, 1966. Other studies lent further credence to Osen's scheme in terms of projections patterns (Warr, 1982) and intrinsic electrical properties (Oertel, 1999). Osen's insightful observations have thus served as an organizational principle which enabled the remarkable progress in the understanding of this nucleus in the 1970s and 1980s.The study of the CN highlights one of the most interesting features of the auditory system: its morphological and physiological specializations to process temporal information in the acoustic waveform. We focus here on temporal processing and two neuron types, called the spherical and globular cells by Osen, and point out an unsolved puzzle.Address for correspondence: Philip X. Joris, Lab Auditory Neurophysiology, Campus GHB O&N2, Herestraat 49 bus 1021, B-3000 Leuven, Belgium, Phone: +32 16 34 57 41, Fax: +3216 33 04 93, Philip.Joris@med.kuleuven.be. Section editor: Prof. Ole Petter Ottersen Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers tha...

show abstract

“…The LSO receives excitatory inputs from SBCs in the ipsilateral VCN (Cant and Casseday 1986;Cant and Benson 2003). Inhibitory inputs originate in the ipsilateral medial nucleus of the trapezoid body (MNTB) which are driven by globular bushy cells (GBCs) in the contralateral VCN (Kuwabara et al 1991;Smith et al 1991).…”

Section: Type X and Tail Unitsmentioning

confidence: 99%

Effects of Unilateral Acoustic Trauma on Tinnitus-Related Spontaneous Activity in the Inferior Colliculus

Ropp

Tiedemann

Young

et al. 2014

JARO

View full text Add to dashboard Cite

This study describes the long-term effects of soundinduced cochlear trauma on spontaneous discharge rates in the central nucleus of the inferior colliculus (ICC). As in previous studies, single-unit recordings in Sprague-Dawley rats revealed pervasive increases in spontaneous discharge rates. Based on differences in their sources of input, it was hypothesized that physiologically defined neural populations of the auditory midbrain would reveal the brainstem sources that dictate ICC hyperactivity. Abnormal spontaneous activity was restricted to target neurons of the ventral cochlear nucleus. Nearly identical patterns of hyperactivity were observed in the contralateral and ipsilateral ICC. The elevation in spontaneous activity extended to frequencies well below and above the region of maximum threshold shift. This lack of frequency organization suggests that ICC hyperactivity may be influenced by regions of the brainstem that are not tonotopically organized. Sound-induced hyperactivity is often observed in animals with behavioral signs of tinnitus. Prior to electrophysiological recording, rats were screened for tinnitus by measuring gap pre-pulse inhibition of the acoustic startle reflex (GPIASR). Rats with positive phenotypes did not exhibit unique patterns of ICC hyperactivity. This ambiguity raises concerns regarding animal behavioral models of tinnitus. If our screening procedures were valid, ICC hyperactivity is observed in animals without behavioral indications of the disorder. Alternatively, if the perception of tinnitus is strictly linked to ongoing ICC hyperactivity, our current behavioral approach failed to provide a reliable assessment of tinnitus state.

show abstract

Afferents to the medial nucleus of the trapezoid body and their collateral projections

Cited by 188 publications

References 57 publications

Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

The volley theory and the spherical cell puzzle

Effects of Unilateral Acoustic Trauma on Tinnitus-Related Spontaneous Activity in the Inferior Colliculus

Contact Info

Product

Resources

About