Afghan Chehelghoza (Pinus gerardiana L.) Pine Nut Diet Enhances the Learning and Memory in Male Rats

Alami, Kawsar; Mousavi, Sayed Yousof

doi:10.2147/nds.s278350

Cited by 11 publications

(10 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[10] Nature gifts various plants and fruits to humans. [11] Medicinal plants are a part of complementary and alternative medicines that are widely used by many people, especially in developing countries. Researchers all over the world are also focused on the effect of medicinal plants and their constituents on diabetes, because of their fewer side effects than synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

Self Cite

View full text Add to dashboard Cite

The prevalence of type 2 diabetes is increasing and considered a major cause of mortality in the world. Medicinal plants are a part of complementary and alternative medicine, which have wide use in the treatment of diabetes. Besides, combination therapy as an effective therapeutic strategy is highly recommended for controlling hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Rheum Ribes L. and Urtica Dioica L. extracts either alone or in combination on blood glucose level in type 2 diabetic rats. Diabetes was induced by single-dose administration of Streptozotocin (50 mg/kg) in rats. Diabetic rats were received intraperitoneal administration of R. Ribes aqueous extract (40 and 60 mg/kg), U. Dioica aqueous-alcoholic extract (100 and 200 mg/kg), and their combination for 21 days. The fasting blood glucose and body weight of rats were determined on 0, 7 th , 14 th , and 21 st days. The results showed that R. Ribes extract (40 and 60 mg/kg), U. Dioica extract (200 mg/kg), and their combination could significantly decrease the blood glucose level on 0, 7 th , 14 th , and 21 st days (P<0.0001). Only 200 mg/kg of U. Dioica had a positive effect on the bodyweight loss of diabetic rats (P<0.01). It can be concluded that Afghan R. Ribes and U. Dioica extracts and their combination have a hypoglycemic effect. However, their combinations do not show any synergic or antagonistic effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

Self Cite

View full text Add to dashboard Cite

show abstract

“…The time spent in the target quadrant and brain weight were significantly increased in rats receiving 12 and 25% P. gerardiana diet ( p < .05). Moreover, in 25% of P. gerardiana ‐treated rats, spontaneous alternation and crossing rate, the time spent in, and the number of entries into open arms were significantly different from the control groups, indicating the beneficial effects of P. gerardiana in improving spatial working and reference memory, increasing the brain weight, and reducing anxiety behavior (Alami & Mousavi, 2020).…”

Section: Resultsmentioning

confidence: 99%

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Iranshahy

Javadi

Sahebkar

2022

Phytotherapy Research

View full text Add to dashboard Cite

In Persian Medicine (PM), PD (brain‐based tremor) is a known CNS disorder with several therapeutic and preventive options. In their medical textbooks and pharmacopeias, Persian great scientists such as Rhazes (854–925 AD), Avicenna (980–1037 AD), and Jorjani (1042–1136 AD), have discussed pharmacological and nutritional strategies for the prevention, slowing progression, and treatment of PD. In the present study, we surveyed plant‐ and animal‐based foods recommended by PM for the prevention and treatment of CNS‐related tremors. In vivo and in‐vitro pharmacological evidence supporting the beneficial effects of PM‐recommended foods in prevention and alleviating PD, major active phytochemicals along with the relevant mechanisms of action were studied. Several PM plants possess potent antioxidant, antiinflammatory, and PD preventing properties. Garlic and allicin, cabbage and isothiocyanates, chickpea seed and its O‐methylated isoflavones biochanin A and formononetin, cinnamon, and cinnamaldehyde, saffron and its crocin, crocetin, and safranal, black cumin and its thymoquinone, black pepper and piperine, pistachio and genistein and daidzein, and resveratrol are among the most effective dietary itemsagainst PD. They act through attenuating neurotoxin‐induced memory loss and behavioral impairment, oxidative stress, and dopaminergic cell death. PM‐recommended foods can help alleviate PD progression and also discovering and developing new neuroprotective anti‐PD pharmaceuticals.

show abstract

“…(Duan et al 2017). Investigations on Chilgoza pine ecology (Kumar et al 2013), seed germination (Saeed and Thanos 2006), genetic variability of phenotypic traits (Kant et al 2006a), seed protein properties (Cai et al 2013), storage and drying treatments (Malik et al 2013;Thakur et al 2014), and morphometric characters (Ranot and Shrama 2015) have been carried out in other countries, especially in India and Pakistan, and also in Afghanistan (Khurram and Shalizi 2016;Safari et al 2017;Alami and Mousavi 2020). In natural populations of P. gerardiana, high levels of genetic variation at RAPD (Randomly Amplified Polymorphism DNA) markers were found within populations in India (Kant et al 2006b).…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity and fine-scale spatial genetic structure of the near-threatened Pinus gerardiana in Gardiz, Afghanistan

Moosavi¹,

Budde²,

Mueller³

et al. 2022

plecevo

View full text Add to dashboard Cite

Background and aims – Chilgoza pine (Pinus gerardiana) is a near-threatened tree species from the north-western Himalayas. This species is the economically most important pine in Afghanistan because of its edible nuts; however, its distribution range is disjunct and restricted to a few isolated regions. The IUCN lists Chilgoza as a near threatened species because of overexploitation of its nuts and a declining population trend. This research is the first in-depth analysis of the genetic variability and structure of Chilgoza in Afghanistan using microsatellite markers. Material and methods –We tested cross-amplification of 44 SSR markers developed for pine species. Eight polymorphic EST-SSRs were genotyped in a natural Chilgoza population in Gardiz, Afghanistan. To evaluate the genetic diversity, fine-scale spatial genetic structure (SGS), signatures of bottleneck events, and the effective population size, 191 trees were sampled and genotyped. Based on the diameter at breast height, individuals were classified as young or old trees. Key results – Genetic variation in the whole population was moderate. For individual markers, He ranged from 0.130 to 0.515 (mean = 0.338) and Ho from 0.118 to 0.542 (mean = 0.328). The expected heterozygosity in young trees was slightly lower than in old trees. The SGS was stronger for young trees (Sp = 0.0100) than for old trees (Sp = 0.0029). Heterozygosity excess analysis detected no recent population size reduction, but the M ratio revealed an ancient and prolonged bottleneck in the Chilgoza population. Conclusion – Identification of suitable EST-SSRs for future studies of natural Chilgoza populations provides important tools for the conservation of the species. Despite the moderate genetic variation in Gardiz, scarcity of natural regeneration is likely to reduce the genetic variation and adaptability in future generations. Our results indicated a slight decrease in genetic diversity and stronger SGS in young trees calling for conservation measures fostering natural regeneration.

show abstract

Afghan Chehelghoza (Pinus gerardiana L.) Pine Nut Diet Enhances the Learning and Memory in Male Rats

Cited by 11 publications

References 45 publications

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Genetic diversity and fine-scale spatial genetic structure of the near-threatened Pinus gerardiana in Gardiz, Afghanistan

Contact Info

Product

Resources

About