Aflatoxin B1 – a potential endocrine disruptor – up-regulates CYP19A1 in JEG-3 cells

Storvik, Markus; Huuskonen, Pasi; Kyllönen, Taija; Lehtonen, Šárka; El-Nezami, Hani; Auriola, Seppo; Pasanen, Markku

doi:10.1016/j.toxlet.2011.01.028

Cited by 53 publications

(34 citation statements)

References 32 publications

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“…It is known that AFB 1 is metabolized by cytochrome P450 (CYPs) enzymes (Buhler and Wang-Buhler 1998). Furthermore, Storvik et al (2011) and Huuskonen et al (2013) supported that AFB 1 increases the expression of CYP19A1 in human placenta cells. More specifically, Huuskonen et al (2013) indicated that AFB 1 affected the placental steroid hormone synthesizing, metabolizing, and conjugating enzymes and that these alterations may lead to anomalies in the foetoplacental hormonal homeostasis, while Storvik et al (2011) suggested that AFB 1 , after being metabolized in aflatoxicol, had effects on genes important for endocrine regulation in placental cells.…”

Section: Discussionmentioning

confidence: 91%

“…Recently, AFB 1 has been categorized as a potential endocrine disruptor (Storvik et al 2011). It is known that AFB 1 is metabolized by cytochrome P450 (CYPs) enzymes (Buhler and Wang-Buhler 1998).…”

Section: Discussionmentioning

confidence: 99%

“…The risk was found to be more serious in high-risk countries, such as Egypt (Piekkola et al 2012). Furthermore, Storvik et al (2011) indicated that chronic exposure to AFB 1 might cause endocrine disruption in the human foetoplacental unit due to its effect on the expression of aromatase enzymes (P450s or CYPs enzymes), categorizing AFB 1 as a potential endocrine disruptor.…”

Section: Introductionmentioning

confidence: 99%

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Effect of prolonged aflatoxin B<sub>1</sub> administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --

Kourousekos

Theodosiadou

Lymberopoulos

et al. 2015

Czech J. Anim. Sci.

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ABSTRACT:The effect of prolonged aflatoxin B 1 (AFB 1 ) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the anoestrus period was investigated. Thirty Greek indigenous goats were used; 10 goats received, per os, 50 μg (treated group T50) and 10 goats received 100 μg (treated group T100) AFB 1 /day/head, respectively, for 31 days, while 10 goats served as controls (C). Blood samples were collected from each goat twice a week to determine serum oestradiol-17β and progesterone concentrations by radioimmunoassay. Multiple linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum oestradiol-17β concentration over group (C = 0, T50 = 50, T100 = 100), in a dosedependent manner, and a significant (P < 0.05) negative dependence over time (0-31 days, from the onset to the end of AFB 1 administration). Linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum progesterone concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner. Pearson's correlation coefficient revealed a significant (P < 0.05) positive correlation between blood serum oestradiol-17β and progesterone concentration, but only in the goats of the control group. In conclusion, the prolonged administration of 100 or even of 50 μg AFB 1 /day/head during the anoestrus period, increased blood serum oestradiol-17β and progesterone concentrations of goats, in a dose-dependent manner, and in the treated groups disturbed the positive correlation between oestradiol-17β and progesterone concentration shown in the goats of the control group.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of prolonged aflatoxin B<sub>1</sub> administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --

Kourousekos

Theodosiadou

Lymberopoulos

et al. 2015

Czech J. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…Storvik et al (2011) and Huuskonen et al (2013) supported that aflatoxin B 1 increases the expression of a cytochrome enzyme (CYP19A1) in human placenta cells. More specifically, Huuskonen et al (2013) indicated that aflatoxin B 1 affected the placental steroid hormone synthesizing, metabolizing and conjugating enzymes.…”

mentioning

confidence: 80%

“…More specifically, Huuskonen et al (2013) indicated that aflatoxin B 1 affected the placental steroid hormone synthesizing, metabolizing and conjugating enzymes. These alterations may lead to anomalies in the foetoplacental hormonal homeostasis, while Storvik et al (2011) suggested that aflatoxin B 1 , after being metabolized in aflatoxicol, had effects on genes that were important for endocrine regulation in placental cells.…”

mentioning

confidence: 99%

Effects of aflatoxins on male reproductive system: A review

Kourousekos¹,

Theodosiadou

2018

J Hellenic Vet Med Soc

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ABSTRACT. Mycotoxins constitute toxic substances produced by certain species of fungi. Among other mycotoxins, aflatoxins are considered to be really dangerous, since they are characterized as carcinogenic for animals and humans. The consumption of aflatoxins through feeds or foods could lead to deleterious effects on animals' or humans' health. Research on animals has shown that the general body condition as well as some of the blood parameters, mainly those of the liver could be negatively affected with aflatoxin administration. Regarding the reproductive system, although not extensively studied, some investigators support the negative effects of aflatoxins either on females or on males. More specifically, in male, the size and weight of the genital organs, the spermatogenesis, the number, the motility and the morphology of sperm cells as well as hormones' concentrations could be affected after exposure of the animals to aflatoxins, making infertility problems more frequent. Most studies refer to laboratory and less to productive animals, while only two studies refer to the possible problems of infertility on men due to aflatoxins. Since reproduction consists one of the most important sectors of animal husbandry, special attention should be paid to nutrition so that the possibility of the aflatoxin consumption by animals would be eliminated, the animal health especially regarding the reproductive system would be protected and economic losses would be ameliorated.

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Mycotoxins

Gupta¹

2017

Nutritional Management of Equine Diseases and Special Cases

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Aflatoxin B1 – a potential endocrine disruptor – up-regulates CYP19A1 in JEG-3 cells

Cited by 53 publications

References 32 publications

Effect of prolonged aflatoxin B<sub>1</sub> administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --

Effect of prolonged aflatoxin B<sub>1</sub> administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --

Effects of aflatoxins on male reproductive system: A review

Mycotoxins

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