Aflatoxin exposure produces serum alphafetoprotein elevations and marked oval cell proliferation in young male Pekin ducklings

Investigation of the Biochemical and Histological Changes Induced by Zearalenone Mycotoxin on Liver in Male Mice and the Protective Role of Crude Venom Extracted from Jellyfish <i>Cassiopea Andromeda</i>

“…Normally, no production of this marker occurs in the adult cells, but it can be secreted when these cells transformed to cancer cells. Similar finding was observed by Sell et al [23] and Abdel-Wahhab et al [24] who found that aflatoxins feeding to ducks for longer term and rats for 6 days produced an elevation in the level of serum AFP. Our result may be attributed to estrogen like effect of ZEN, because estrogens can interact with specific receptors called estrogen receptors (ER) in the liver and exerting a number of toxic effects, including liver adenomas and hepatocarcinomas [25,26].…”

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

“…Similarly, Verma et al, (2004) reported a significant decrease in the relative weight of the bursa of Fabricius when birds were exposed to diets having 2000 ppb AF. Similar reduction in BBR and moderate histopathological changes have been reported in broilers (Giambrone et al, 1985;Marquez and Hernandez, 1995), laying hens (Dafalla et al, 1987), ducks (Sell et al, 1998;Khajarern and Khajarern, 1999) and wild turkeys (Quist et al, 2000) when birds were fed diets having various levels of AF (100 to 500 ppb). In addition, vacuolation of liver cells and cellular depletion in the follicle medulla of the bursa Fabricii has been reported to be produced as an indication of aflatoxicosis by feeding lower levels of AF (100 ppb) over a long-term period of 42 days (Espada et al, 1992).…”

Interaction of aflatoxin B1and fumonisin B1in mice causes immunotoxicity and oxidative stress: Possible protective role using lactic acid bacteria

“…Aflatoxin B 1 (AFB 1 ) has been implicated as an etiological factor, apart from hepatitis B virus, in development of human liver cancer (van Rensburg et al, 1985). In transgenic mice it was shown that over-expression of the hepatitis B virus large peptide envelope acted synergistically with AFB 1 in impacting on neoplastic development and other forms of chronic liver damage (Sell et al, 1998). Other studies have indicated that fumonisin B 1 (FB 1 ) is also a hepato-carcinogen in BD IX rats; another study reported on its nephro-carcinogenicity in Fischer rats and liver of B 6 C 3 F 1 mice (Howard et al, 2001).…”