AFM in peak force mode applied to worn siloxane-hydrogel contact lenses

Abstract

The objective of this work is to apply Atomic Force Microscopy in Peak Force mode to obtain topographic characteristics (mean roughness, root-mean-square roughness, skewness, kurtosis) and mechanical characteristics (adhesion, elastic modulus) of HighlightsThe Peak Force mode of AFM provides topographic and mechanical properties.The worn CLs show significant changes in respect to the un-worn CLs.The AFM results can be correlated with clinical test results.The elastic modulus is not the only parameter to consider regarding CL comfort.3

Invariant slow manifolds of an Atomic Force Microscope system under the effects of Lennard-Jones forces and a slow harmonic base motion

“…Abadias et al [24] applied the AFM in peak-force mode to obtain topographic and mechanical characteristics of Siloxane-Hydrogel soft contact lenses. The study was carried out in liquid using cantilevers of silicon nitride of low spring constant (0.1−1N/m) and of natural frequency in liquid between 2 and 20 kHz.…”

Fast automated processing of AFM PeakForce curves to evaluate spatially resolved Young modulus and stiffness of turgescent cells

“…16,[22][23][24] Over the last ten years, the need to lower the limits of spatial detection for addressing the biomolecular processes that control cells response to changes of neighboring environments, has given rise to the development of faster and more accurate force curve measurement technologies, in particular the Peak-Force AFM tapping mode (Bruker technology). 25,26 This mode of force curves acquisition allows a precise control of the sample to AFM probe interactions and a high resolution (nanometer scale) for AFM surface imaging. Methodologies differ according to e.g.…”

In vitro and in vivo effects of ophthalmic solutions on silicone hydrogel bandage lens material Senofilcon A

“…Previous studies investigating interactions between hydrogel contact lenses and the cornea found significant alterations in the surface morphologies of hydrogel contact lenses during use without any eye‐drop medication . The ocular environment itself in general could be prone to create discomfort or pain, and the problems experienced might not be attributed to the usage of eye‐drops alone.…”