AFM studies of the crystallization and habit modification of an excipient material, adipic acid

Incidence of crystal growth conditions on the formation of macroscopic liquid inclusions in ciclopirox crystals

“…It was often highlighted in the literature that impurities are prompt to induce morphological changes through their adsorption on a growing face [25,27,35]. In order to assess this hypothesis in the case of ciclopirox, the influence of impurities was studied using two strategies.…”

Anomalous Particle Size Shift During Post-milling Storage

“…To prepare crystallised adipic acid, 99% pure adipic acid purchased from Sigma-Aldrich was re-crystallised in ultra-pure water using a batch cooling crystallisation method (13). The crystals were vacuum filtered, subsequently dried for 24 h in oven at a temperature of 55°C and then stored for 24 h in a dessicator using phosphorus pentoxide.…”

Following the surface response of caffeine cocrystals to controlled humidity storage by atomic force microscopy

“…An incorrect species could be an impurity or one of the cocrystal components aligned out of sequence. Pinning sites are regularly observed when impurities are added as growth modifiers to organic crystals (Keel et al, 2004;Thompson et al, 2004). If steps were prevented from propagating parallel to the crystal face then instead movement could be directed normal to the face, resulting in the observed growth.…”