African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation

Li, Yuhui; Peng, Jiangling; Xu, Zhihong; Xiong, Ming; Wu, Haoming; Wang, Suyun; Zheng, Haixue; Zhu, Guoqiang; Ran, Yong; Wang, Yan-Yi

doi:10.1128/jvi.01942-22

Cited by 18 publications

(9 citation statements)

References 25 publications

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“…Gene fragment CD2v (EP402R) has a sequence of 1083 bp, encoding protein that has significant roles in immune evasion and infection process (Li et al, 2023). This protein is also important in erythrocyte binding, together with other proteins found on the membrane such as p54, p22 and p12 (Vlasova et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Genetic analysis of African swine fever virus in Bali based on p72 and CD2v Genes

Putu Andarisa Widyastiti,

I Gusti Ngurah Kade Mahardika,

Ida Bagus Kade Suardana

2024

Int. J. Sci. Technol. Res. Arch

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African Swine Fever (ASF) has caused negative effects in the swine industry in various countries of the world, including Indonesia. Bali is one of the most severely affected provinces in Indonesia. Phylogenetic study to determine the genotype and serogroup of the ASF virus found in Bali has never been done before. In this study, virus was obtained from an infected spleen sample, designated as Bali/2023, and two gene fragments, namely p72 (B646L) and CD2v (EP402R), were then amplified by PCR and sequenced by Sanger method. The DNA sequences of p72 and CD2v virus was then compared with sequences from other countries for genetic analysis. The results showed that Bali/2023 virus is genetically very close to viruses found in other Asian countries, mainly viruses isolated in China and Vietnam in 2019. These genetic analyses results placed Bali/2023 virus in genotype II and serogroup 8.

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Section: Resultsmentioning

confidence: 99%

Genetic analysis of African swine fever virus in Bali based on p72 and CD2v Genes

Putu Andarisa Widyastiti,

I Gusti Ngurah Kade Mahardika,

Ida Bagus Kade Suardana

2024

Int. J. Sci. Technol. Res. Arch

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“…MGF360–9 L interacts with and degrades STAT1 and STAT2 via the apoptosis and proteasome pathways ( Zhang et al., 2022b ). pS273R and pA104R lead to the degradation of STAT2 and attenuation of STAT1 phosphorylation, respectively ( Chen et al., 2023 ; Li et al., 2023 ). pI215L triggers the degradation of IRF9 and STAT2 through autophagy-lysosome and proteasome pathways, respectively ( Li et al., 2022 ; Riera et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

African Swine Fever Virus pF778R Attenuates Type I Interferon Response by Impeding STAT1 Nuclear Translocation

Chen

Liu

et al. 2023

Virus Research

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“…Thereby, the downstream of TBK1 is negatively regulated [85]. The immunosuppression protein S273R of ASFV interacts with STAT2 and recruited the E3 ubiquitin ligase DCS1, leading to K48-linked polyubiquitin chains at K55 of STAT2, subsequently prompting the degradation of STAT2 via the proteasome pathway [86]. The ubiquitination serves as a modification mechanism utilized by various viruses that influences the normal functions of signaling pathway by interacting with specific proteins.…”

Section: Other Modulationsmentioning

confidence: 99%

African Swine Fever Virus Immunosuppression and Virulence Related Gene

Huang,

Li,

Xia

et al. 2024

Preprint

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African swine fever virus (ASFV), a highly contagious pathogen characterized by a complex structure and a variety of immunosuppression proteins, causes hemorrhagic, acute, and aggressive infectious disease that severely injure the pork product and industry. However, there is no effective vaccine or treatment. The main reasons are not only the complex mechanisms that lead to immunosuppression, but also the unknown functions of various proteins. This review summarizes the interaction between ASFV and host immune system, along with the involvement of virulence related genes and proteins, as well as the corresponding molecular mechanism of immunosuppression of ASFV, encompassing pathways such as cGAS-STING, NF-κB, JAK/STAT, apoptosis, and other modulation. The aim is to summarize the dynamic process during the ASFV infection and entry into host cell, provide a rational insight into development of vaccine and a better clear knowledge of how ASFV impacts host.

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African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation

Abstract: ASF is an acute disease in domestic pigs caused by infection with ASFV. ASF has become a global threat with devastating economic and ecological consequences.

Cited by 18 publications

References 25 publications

Genetic analysis of African swine fever virus in Bali based on p72 and CD2v Genes

Genetic analysis of African swine fever virus in Bali based on p72 and CD2v Genes

African Swine Fever Virus pF778R Attenuates Type I Interferon Response by Impeding STAT1 Nuclear Translocation

African Swine Fever Virus Immunosuppression and Virulence Related Gene

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