By the middle of the 20 th Century, following the groundbreaking work of Esther Boserup, feminist analysis began to acknowledge the active participation of African women in their countries' economic systems as producers. However, it was quite obvious, even to Boserup that while there was no doubt about women's participation, historically the gains from trade devolve disproportionately to men, a problem compounded by the fact that the institutions that manage the trading system locally, nationally, regionally and globally are dominated by men. Unfortunately, contemporary awareness that the gains from trade are uneven has not yielded the transformation of the global political economy such that the observed disparities are corrected. These disparities have extraordinary distributional consequences for gender equality, since they stimulate differential responses between economic sectors, producers, regions in national and international economic systems, between advanced industrial and post industrial developed countries as compared with the predominantly agrarian, nonindustrial, developing nations, or the Northern and Southern hemispheres, as well as between and within African countries. Advancements in trade and the profitability therefrom have generated prodigious amounts of wealth. Invariably, some of the gainers from trade are women. But even as some women gain from trade, most others suffer and are excluded from the benefits of trade. Given that the world has also widely acknowledged that there is a need to promote gender equity and equality, and many international instruments attest to this commitment, why are the disparities in gains from trade in the global economic system still heavily weighted in favor of men as compared with women? Facilitating equitable and equal gains from trade not only contributes to actualizing stated commitments to end all forms of discrimination against women, the goals of the Beijing Declaration and Platform of Action, and the achievement of the Millennium Development Goals, it also devolves positively to the enhancement of human well-being. Given that African countries have affirmed their commitment to these various international instruments and purport to be seized of the necessity of achieving gender equality, concrete gains in gender equality in trade would more demonstrably underline their commitment. With a focus on: The Multilateral Trading System and WTO Agreements; Economic Partnership Agreements (EPAs) and their impacts on African Women; and Regional Trade Agreements (RTAs): Lessons Learned from RECs (and possibly SROs), this paper will consider post 1945 African political economy, examine the continued parlous gains made by African women and attempt to explain the domestic and international causes and consequences of their marginalization. It will also suggest some remedies.