Ag@Fe3O4@C nanoparticles for multi-modal imaging-guided chemo-photothermal synergistic targeting for cancer therapy

Wang, Mingqian; Liang, Ying; Zhang, Zhicheng; Ren, Guohong; Liu, Yajun; Wu, Shishan; Shen, Jian

doi:10.1016/j.aca.2019.08.035

Cited by 48 publications

(28 citation statements)

References 43 publications

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“…Moreover, chemo-photothermal combination therapy can augment cell membrane permeability [119,120]. Accordingly, many nanosystems for combined PTT and chemotherapy, including inorganic NPs [121], micelles [122], and polymeric NPs [123], have been developed. Nevertheless, a few critical issues lowered the therapeutic outcomes, such as uncontrolled release and low-dose drug accumulation in tumor tissue.…”

Section: Photothermal Chemotherapymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Photothermal Chemotherapymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…By contrast, efficient anti-tumor effects were noticed in BP-P/D and BP-P-Apt/D groups compared with free DOX. This is attributed to more accumulation of DOX in tumor sites due to EPR effects (Cheng et al, 2017d;Wang et al, 2019b). Besides, BP-P-Apt/D showed a more effective tumor ablation effect than BP-P/D, implying a good tumor targeting ability of Apt.…”

Section: In Vivo Therapeutic Effectmentioning

confidence: 99%

Zinc Ion-Stabilized Aptamer-Targeted Black Phosphorus Nanosheets for Enhanced Photothermal/Chemotherapy Against Prostate Cancer

Gao

Teng

Zhang

et al. 2020

Front. Bioeng. Biotechnol.

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Prostate cancer is the second most common malignancy among men worldwide. However, conventional chemotherapy, such as taxane therapy, fails to exhibit efficient treatment for almost half of the patients. In this study, a nano-drug delivery system based on black phosphorus nanosheets (BP NSs) was developed, which was then employed as a multifunctional nanoplatform for targeted combinational chemo-photothermal therapy against prostate cancer. Zinc ion (Zn 2+), which has been proven to be able to inhibit prostate cancer cell proliferation, was also introduced into this system. Zn 2+ coordination could not only enhance the therapeutic effect of combined chemophotothermal therapy, but also improve the intrinsic instability of BP NSs through the stabilization of its lone pair electrons. The in vivo study showed the outstanding performance of this system in targeted photothermal/chemotherapy of prostate cancer without side effect to normal organs.

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“…17 Meanwhile, MSR-DDSs can accurately locate and diagnose tumor by magnetic resonance or optical imaging property. 19 Integration of diagnosis and treatment with NPs mediated by exogenous stimuli will be introduced in subsequent chapters. Exogenous stimuli could be regarded as a "switch" to seal the pores of NPs with little leakage of drug and a burst release at targeted sites by triggers, such as a magnetic field, light or heat.…”

Section: Msr-ddss Responsive To Exogenous and Tumor-tissue Triggersmentioning

confidence: 99%

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Jia¹,

Teng²,

Lingyu³

et al. 2021

IJN

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Nanomedicines afford unique advantages in therapeutic intervention against tumors. However, conventional nanomedicines have failed to achieve the desired effect against cancers because of the presence of complicated physiological fluids and the tumor microenvironment. Stimuli-responsive drug-delivery systems have emerged as potential tools for advanced treatment of cancers. Versatile nano-carriers co-triggered by multiple stimuli in different levels of organisms (eg, extracorporeal, tumor tissue, cell, subcellular organelles) have aroused widespread interest because they can overcome sequential physiological and pathological barriers to deliver diverse therapeutic “payloads” to the desired targets. Furthermore, multiple stimuli-responsive drug-delivery systems (MSR-DDSs) offer a good platform for co-delivery of agents and reversing multidrug resistance. This review affords a comprehensive overview on the “landscape” of MSR-DDSs against tumors, highlights the design strategies of MSR-DDSs in recent years, discusses the putative advantage of oncotherapy or the obstacles that so far have hindered the clinical translation of MSR-DDSs.

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Ag@Fe3O4@C nanoparticles for multi-modal imaging-guided chemo-photothermal synergistic targeting for cancer therapy

Cited by 48 publications

References 43 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Zinc Ion-Stabilized Aptamer-Targeted Black Phosphorus Nanosheets for Enhanced Photothermal/Chemotherapy Against Prostate Cancer

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

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