Ag Nanoparticles-enhanced Fluorescence of Terbium-Deferasirox Complexes for the Highly Sensitive Determination of Deferasirox

Abstract

We describe the effect of different sized gold and silver nanoparticles on the terbium sensitized fluorescence of deferasirox. It is indicated that silver nanostructures, especially 18 nm Ag nanoparticles (AgNPs), have a remarkable amplifying effect compared to Au nanoparticles. Based on this observation, a highly sensitive and selective method was developed for the determination of deferasirox. Effects of various parameters like AgNPs and Tb 3+ concentration and pH of media were investigated. Under the optimal conditions, a calibration curve was plotted as the fluorescence intensities versus the concentration of deferasirox in the range of 0.1 to 200 nmol L -1 , and detection limit of 0.03 nmol L -1 was obtained. The method has good linearity, recovery, reproducibility and sensitivity, and was satisfactorily applied for the determination of deferasirox in urine and pharmaceutical samples.

Ratiometric fluorescence assay based on carbon dots and Cu2+-catalyzed oxidation ofO-phenylenediamine for the effective detection of deferasirox

“…Fluorescence technology has attracted extensive interests in drug monitoring ascribed to its sensitivity, facile operation, fast analysis and controllable sample pre-treatment. 11,12 Using the copper ion or terbium ion as a ligand, uorescence strategies through single changed intensity have been fabricated on the basis of a formed DEF-copper chelator 13,14 or DEF-terbium complex 1,15 at the specic testing conditions, such as incubation under alkaline conditions. 13 In general, most uorescence sensing systems containing the uorescence assay for DEF rely on the change of the uorescence intensity from a single emission centre through a "switch-off" or "signal-on" strategy.…”

Silver Nanoparticles

“…Recently, Abolhasani et al reported that the energytransfer luminescence of Tb(III)-deferasirox complexes was enhanced in the presence of AgNPs. 11 As a result, deferasirox was detected with a detection limit of 0.03 nM. Taking advantage of the enhanced field, AgNPs have been utilized in SERS to improve the sensitivity of Raman spectroscopy.…”