Ag@TiO₂ Nanoprisms with Highly Efficient Near‐Infrared Photothermal Conversion for Melanoma Therapy

Abstract

Melanoma is ap rimary reason of death from skin cancer and associated with high lethality.P hotothermalt herapy (PTT) has been developed into ap owerful cancer treatment technique in recenty ears. Here, we createdalow-cost and high-performance PTT agent,A g@TiO 2 NPs, which possesses ah igh photothermal conversion efficiency of % 65 % and strong near-infrared (NIR) absorption about8 08 nm. Ag NPs were synthesized using at wo-step methoda nd coated with TiO 2 to obtain Ag@TiO 2 NPs by af acile sol-gel method. Because of the oxide, Ag@TiO 2 NPs exhibit remarkable high photothermal conversion efficiencies and biocompatibility in vivo and in vitro. Cytotoxicity and therapeutic efficiency of photothermal cytotoxicity of Ag@TiO 2 NPs were tested in B16-F10c ells and C57BL/6J mice. Under light irradiation, the elevated temperature causes cell death in Ag NPs-treated (100 mgmL À1 )c ells in vitro (both p < 0.01). In the case of subcutaneous melanoma tumor model, Ag@TiO 2 NPs (100 mgmL À1 )w ere injected into the tumor and irradiated with a8 08 nm laser of 2Wcm À2 for 1minute. As ac onsequence, the tumor volumeg radually decreased by NIRl aser irradiation with only as ingle treatment. The results demonstrate that Ag@TiO 2 NPs are biocompatible and an attractive photothermal agent for cutaneous melanoma by local delivery.[a] Dr.

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

“…One of the most widely used stimuli is light, which, combined with NPs, triggers the so-called photothermal effect. In this approach, either cell cultures or laboratory animal tissues exposed to NPs (e.g., AgNPs or titanium dioxide) are treated with radiation, usually a 808 nm NIR laser [ 122 ]. In nanostructures such as gold nanorods (AuNR) [ 107 ], NIR radiation causes a local temperature increase that damages and kills cells.…”

“…On the other hand, photothermal therapy kills cancer cells by using the heat generated from absorbed near-infrared energy with minimum damage between the tumor and the surrounding tissues [ 207 ]. AgNPs coated with TiO 2 , produced by a sol-gel two-step technique, demonstrated their capability of eliminating subcutaneous melanoma tumor in vitro and in vivo in B16-F10 cells and C57BL/6J mice, respectively, when exposed to near-infrared radiation [ 122 ]. Recently, bovine serum albumin (BSA)-coated silver NPs (BSA-AgNPs) have been developed to generate free radicals that were likely derived by oxidative stress to B16F10 cells [ 206 ].…”

Recent Trends in Photoacoustic Imaging Techniques for 2D Nanomaterial-Based Phototherapy

“…TMDs can be formed with various materials including molybdenum disulfide (MoS 2 ) [70][71][72][73], tungsten disulfide (WS 2 ) [74][75][76][77], and molybdenum diselenide (MoSe 2 ) [78][79][80]. Transition metal oxides (TMOs) are compounds of oxygen atoms and transition metals such as titanium (TiO 2 ) [81,82] and manganese (MnO 2 ) [83][84][85]. Their wide bandgap results in excellent photochemical and electric properties [86,87].…”

Treatment of malignant melanoma - a review of the literature

“…Inspired by these facts, the authors of one of this year's studies attempted to deliver an Ag NP-based PTT agent for in vivo cancer therapy [30]. In order to avoid the side effect from external media, there is a need to introduce a protective layer on the outside of Ag NPs such as Au, [31] self-organized monolayers (SAMs) of organic thiols [32] and silica or titanium [33].…”

“…The designed silver nanoparticles coated with titanium dioxide (TiO2) layer did not undergo silver nanoparticle aggregation, showed good chemical stability and good biocompatibility. Oxide coatings have not only increased the stability of Ag nanoparticles, but may also provide a binding site for targeting and tagging molecules in future studies [30] In another study utilizing the therapeutic properties of precious metals, researchers synthesized and applied platinum nanoparticles (PtNPs) for anti-cancer therapy using 808 nm laser light and X-rays or a combination thereof [H]. Two laser power densities (1.…”