Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: Consequences of treatment with antioxidant pyridoindole

Şakul, Arzu; Cumaoğlu, Ahmet; Aydin, Ertan; Arı, Nuray; Dilsiz, Nihat; Karasu, Çi̇men

doi:10.1016/j.exger.2013.02.028

Cited by 22 publications

(19 citation statements)

References 62 publications

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“…Under the "OLEA project" the olive leaf polyphenolic mixture has demonstrated cytoprotective and anti-inflammatory properties in cardiomyocytes, insulin releasing β-cell or skin cell cultures stimulated by H 2 O 2 , 4-HNE or a cytokine cocktail [56,57,89,90]. Our studies using diabetic models showed improved insulin sensitivity [57,85], ameliorated antioxidant enzyme activity [27,34,35,39,41,72], dysregulated glycated protein levels and lipid peroxidation products [34,37,41] by natural antioxidants.…”

Section: The Natural Regulators Of Cellular Redox Homeostasis and Promentioning

confidence: 72%

“…The results obtained from the mimetic aging model rats shows that various anatomical regions of the brain have different susceptibility to oxidative damage of proteins, lipids and DNA [33,34]. In addition to the brain, there are many studies that report increased advanced oxidative and glyco-oxidative protein damage markers in kidney [35,36], heart [27,34,37], pancreas [38], aorta [39,40], liver [41] and serum [42] by aging or accelerated aging models such as diabetes. Advanced oxidation protein products represent dityrosine-containing cross-linked protein modifications formed mainly via myeloperoxidase reaction, and have been demonstrated to accelerate the uremiaassociated atherogenesis and renal fibrosis in children and adolescents [43].…”

Section: Response To Carbonyl Stress: Impaired Cellular Redox Homeostmentioning

confidence: 94%

“…Serum AGEs [N(epsilon)-carboxymethyl-lysine (CML) or methylglyoxal (MG) derivatives] have been found to be higher in older compared to younger subjects [32]. The results obtained from the mimetic aging model rats shows that various anatomical regions of the brain have different susceptibility to oxidative damage of proteins, lipids and DNA [33,34]. In addition to the brain, there are many studies that report increased advanced oxidative and glyco-oxidative protein damage markers in kidney [35,36], heart [27,34,37], pancreas [38], aorta [39,40], liver [41] and serum [42] by aging or accelerated aging models such as diabetes.…”

Section: Response To Carbonyl Stress: Impaired Cellular Redox Homeostmentioning

confidence: 95%

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Natural products and the aging process

Ergin

Bali²,

Hariry

et al. 2013

Hormone Molecular Biology and Clinical Investigation

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Literature surveys show that the most of the research that have been conducted on the effect of herbal remedies on many tissue pathologies, including metabolic disturbances, cardiovascular decline, neurodegeneration, cataract, diabetic retinopathy and skin inflammation, all lead to an accelerated aging process. The increased carbonylation of proteins (carbonyl stress) disturbing their function has been indicated as an underlying mechanism of cellular senescence and age-related diseases. Because it is also linked to the carbonyl stress, aging chronic disease and inflammation plays an important role in understanding the clinical implications of cellular stress response and relevant markers. Greater knowledge of the molecular and cellular mechanisms involved in several pathologies associated with aging would provide a better understanding to help us to develop suitable strategies, use specific targets to mitigate the effect of human aging, prevent particularly chronic degenerative diseases and improve quality of life. However, research is lacking on the herbal compounds affecting cellular aging signaling as well as studies regarding the action mechanism(s) of natural products in prevention of the age-related disease. This review provides leads for identifying new medicinal agents or potential phytochemical drugs from plant sources for the prevention or delaying cellular aging processes and the treatment of some disorders related with accelerated body aging.

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Section: The Natural Regulators Of Cellular Redox Homeostasis and Promentioning

confidence: 72%

Section: Response To Carbonyl Stress: Impaired Cellular Redox Homeostmentioning

confidence: 94%

Section: Response To Carbonyl Stress: Impaired Cellular Redox Homeostmentioning

confidence: 95%

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Natural products and the aging process

Ergin

Bali²,

Hariry

et al. 2013

Hormone Molecular Biology and Clinical Investigation

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“…Similarly, Lee (2006) showed that soy protein and genistein were seemed to be beneficial for correcting hyperglycemia and preventing diabetic complications in diabetes induced rats 37 . Şakul et al (2013) demonstrated that antioxidant pyridoindole reversed the effects of diabetes in rat brain and peripheral tissues 38 . The aqueous extract of Anchusa strigosa flowers (250 mg/kg and 500 mg/kg) caused a dose-dependent fall in blood glycose, cholesterol and triglyceride levels in STZ induced diabetic rats 39 .…”

Section: Diabetes Oxidative Stress and Antioxidantsmentioning

confidence: 99%

Beneficial effects of commonly used phytochemicals in diabetes mellitus

Bacanlı¹,

Göktaş²,

Başaran³

et al. 2016

actapharm

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Diabetes mellitus, a metabolic disorder, is characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycemia. The prevalence of diabetes is increasing worldwide, especially in developing countries. The diabetes treatment has higher costs, limited efficacy and side effects. As a result of these factors, patients often have used alternative forms of therapy such as herbal medicines. Plants often contain various amounts of phenolics, flavonoids and tannins and most of the studies are focused on the antidiabetic effects of these phytochemicals due to their antioxidant properties. In this review, the role of oxidative stress on diabetes and the effects of different phytochemicals (limonene, sinnamic acid and ursolic acid) to diabetes mellitus therapy will be discussed.

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“…The species (ROS) are an attraction with component of cells, such as proteins, lipids, and sugars. This link causes the accumulation of ROS, which leads to cell damage, pathogenic disorders, and diabetes [13,14,15]. The pentose phosphate pathway has two main functions: synthesis of RNA, DNA, and ribose-5-phosphate required for nucleotide synthesis in the cell and the synthesis of NADPH, which is a reducing power in reductive biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Impact of Diabetes Mellitus Type 2 in the Activity of Glucose-6-Phosphate Dehydrogenase in Human Erythrocyte

Hamzah

Hamza²,

Rahman

2018

KJAR

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-Diabetes mellitus is a metabolic affliction saunter that is characterized by a nobler than normal blood glucose poise. Glucose-6-phosphate dehydrogenase (G6PD) enzyme code (E.C.1.1.1.49) is an underlying enzyme in the phosphogluconate pathway. In this study, G6PD vitality in the mortal erythrocyte of male and female patients with type 2 diabetes mellitus was assessed utilizing a spectrophotometer at 340 nm. The activity of the enzyme increased with elevated glycated haemoglobin (HbA1C) levels. G6PD activity was found to be significantly associated with type 2 diabetes mellitus. The association between G6PD and diabetes mellitus was significant (P < 0.001). Moreover, G6PD was positively correlated with HbA1C levels (r = 0.572). The following mean ± standard deviation values were obtained: G6PD activity (IU/g Hb), 3.1103 ± 0.79349; HbA1C (%), 8.6600 ± 1.63120; Hb (g/dL), 13.4933 ± 1.38836; platelet count (103/µl), 283.4667 ± 58.59312; WBC (103/µl), 7.4890 ± 1.49842; HCT (%), 45.0100 ± 2.63430; and BS (mg/dL), 230.2667 ± 75.67760. The results showed that an elevated HbA1C up leads to increased G6PD performance in the human erythrocyte, which is concerning to glucose levels in the special (blood).

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Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: Consequences of treatment with antioxidant pyridoindole

Cited by 22 publications

References 62 publications

Natural products and the aging process

Natural products and the aging process

Beneficial effects of commonly used phytochemicals in diabetes mellitus

Impact of Diabetes Mellitus Type 2 in the Activity of Glucose-6-Phosphate Dehydrogenase in Human Erythrocyte

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