Age and education adjusted normative data and discriminative validity for Rey’s Auditory Verbal Learning Test in the elderly Greek population

Abstract

Rey's Auditory Verbal Learning Test (RAVLT) is a widely used neuropsychological test to assess episodic memory. In the present study we sought to establish normative and discriminative validity data for the RAVLT in the elderly population using previously adapted learning lists for the Greek adult population. We administered the test to 258 cognitively healthy elderly participants, aged 60-89 years, and two patient groups (192 with amnestic mild cognitive impairment, aMCI, and 65 with Alzheimer's disease, AD). From the statistical analyses, we found that age and education contributed significantly to most trials of the RAVLT, whereas the influence of gender was not significant. Younger elderly participants with higher education outperformed the older elderly with lower education levels. Moreover, both clinical groups performed significantly worse on most RAVLT trials and composite measures than matched cognitively healthy controls. Furthermore, the AD group performed more poorly than the aMCI group on most RAVLT variables. Receiver operating characteristic (ROC) analysis was used to examine the utility of the RAVLT trials to discriminate cognitively healthy controls from aMCI and AD patients. Area under the curve (AUC), an index of effect size, showed that most of the RAVLT measures (individual and composite) included in this study adequately differentiated between the performance of healthy elders and aMCI/AD patients. We also provide cutoff scores in discriminating cognitively healthy controls from aMCI and AD patients, based on the sensitivity and specificity of the prescribed scores. Moreover, we present age- and education-specific normative data for individual and composite scores for the Greek adapted RAVLT in elderly subjects aged between 60 and 89 years for use in clinical and research settings.

Focal white matter disruptions along the cingulum tract explain cognitive decline in amnestic mild cognitive impairment (aMCI)

“…Further, our aMCI sample had a marginally higher education level compared with HC that could explain the lack of significant group differences in RAVLT performance in our study. This is supported by previous reports that suggest a significant association between education level and RAVLT performance in older populations 26 .…”

Normative data of the Brazilian elderly in Logical Memory subtest of WMS-R

“…These results are consistent with those of Nitrini (2008), and other studies also showed positive correlations between education and VEM tasks (Gabriel & Conboy, 2010;Messinis et al, 2016). In the study of Angel et al (2010) four groups were assessed according to age (young and elderly) and education (low and high) in a VEM test.…”

Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI

“…RAVLT performance is influenced by subjects’ demographic characteristics, including age, education, and sex [15]. The RAVLT delayed recall score has been reported to have adequate discrimination in older adults with normal cognition vs. MCI (AUC = 0.71) and good discrimination for normal cognition vs. dementia (AUC = 0.93) [16].…”