Age‐ and gender‐specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China

Yin, Junhua; Song, Zi-Xia; Shan, Peng-Fei; Jin, Xu; Ye, Zhimin; Xiao-min, XU; Zhang, Songzhao; Qin, Liang; Zhao, Yi; Ren, Zhen; Yu, Yiping

doi:10.1111/j.1365-2265.2011.04198.x

Cited by 36 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other words, MetS predicted the occurrence of new carotid plaque and may be correlated with changes in IMT over time. These results are consistent with the findings of several longitudinal 15,16,23,24) and cross-sectional studies 14,25,26) that addressed the relationships between MetS, carotid plaque and C-IMT. In the present study, the presence of carotid plaque was associated with accelerated C-IMT changes (Cont Table 1 stress and proinflammatory signaling in the vessel wall 38) .…”

Section: Discussionsupporting

confidence: 81%

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Jung

Kwon

Han

et al. 2014

JAT

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 81%

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Jung

Kwon

Han

et al. 2014

JAT

View full text Add to dashboard Cite

“…Men were likely to have extracranial atherosclerosis, which has been proved in other population. 26 These results are similar to those of Flora et al, 10 who found that the frequency of cerebral atherosclerosis increases more rapidly in women after the sixth decade. In our study, elderly women have more diabetes mellitus, hypertension, hyperlipidemia, and history of heart disease, which can help explain the difference.…”

Section: Sex Difference In Icassupporting

confidence: 82%

Geographic and Sex Difference in the Distribution of Intracranial Atherosclerosis in China

Liu

Wang

et al. 2013

Stroke

View full text Add to dashboard Cite

Background and Purpose-Geographic variation and sex difference in the distribution of intracranial atherosclerosis (ICAS) have not been fully discussed before in Chinese patients with cerebral ischemia. We performed this study with the aim to investigate geographic and sex difference in the distribution of ICAS in China. Methods-In this prospective multicenter study, we evaluated 2864 consecutive patients who experienced an acute cerebral ischemia within 7 days of symptom onset in 22 hospitals in China. All the inclusive patients underwent 3-dimensional time-of-flight MR angiography and duplex color Doppler ultrasound or contrast-enhanced MR angiography to document the presence of intracranial or extracranial stenosis. Intracranial large-artery atherosclerosis was defined as ≥50% diameter reduction on MR angiography. Results-The proportion of patients with ICAS was significantly higher in north China than in south China (50.22% versus 41.88%; P<0.0001). Patients in the north were likely to consume more alcohol and smoke more cigarettes and had significantly higher proportion of diabetes mellitus, family history of stroke, history of cerebral ischemia, heart disease, and higher body mass index. In patients aged >63 years, the percentage of ICAS in women was notably higher than in men (51.51% versus 45.40%; P=0.028). In elderly patients, women had higher proportion of diabetes mellitus, hypertension, hyperlipidemia, and heart disease than men. Conclusions-There exists geographic and sex difference in the distribution of symptomatic ICAS in China. Public health measures should strengthen improving social determinants of health and risk factor prevention/control in high-risk populations for decreasing stroke risk. (Stroke. 2013;44:2109-2114.)

show abstract

“…To compare our results with previous studies, we searched PubMed to identify population‐based studies that reported the prevalence of CA detected by ultrasound in China, and summarized findings are shown in Table 4. Of these previous studies,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 only the CKB (China Kadoorie Biobank) study included a large sample of participants (N=24 822) from multiple geographic regions in China16; all other studies were geographically local. The CKB study reported that the overall prevalence of carotid plaque was 31%, which was much higher than the prevalence of 13.9% in the present study; however, the CKB study included participants with stroke (5.4%) or coronary heart disease (7.5%).…”

Section: Discussionmentioning

confidence: 99%

Carotid Atherosclerosis Detected by Ultrasonography: A National Cross‐Sectional Study

Wang¹,

Li²,

Song

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundCarotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrasonography and related risk factors based on a national survey in China.Methods and ResultsA total of 107 095 residents aged ≥40 years from the China National Stroke Prevention Project underwent carotid ultrasound examination. Participants with carotid endarterectomy or carotid stenting and those with stroke or coronary heart disease were excluded. Data from 84 880 participants were included in the analysis. CA was defined as increased intima–media thickness (IMT) ≥1 mm or presence of plaques. Of the 84 880 participants, 46.4% were men, and the mean age was 60.7±10.3 years. The standardized prevalence of CA was 36.2% overall, increased with age, and was higher in men than in women. Prevalence of CA was higher among participants living in rural areas than in urban areas. Approximately 26.5% of participants had increased IMT, and 13.9% presented plaques. There was an age‐related increase in participants with increased IMT, plaque presence, and stenosis. In multiple logistic regression analysis, older age, male sex, residence in rural areas, smoking, alcohol consumption, physical inactivity, obesity, hypertension, diabetes mellitus, and dyslipidemia were associated with CA.Conclusions CA was highly prevalent in a middle‐aged and older Chinese population. This result shows the potential clinical importance of focusing on primary prevention of atherosclerosis progression.

show abstract

Age‐ and gender‐specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China

Abstract: These results indicate that CA and CP have become a major public health problem in China. MetS and its components were associated with an increased prevalence of CA and CP.

Cited by 36 publications

References 35 publications

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Geographic and Sex Difference in the Distribution of Intracranial Atherosclerosis in China

Carotid Atherosclerosis Detected by Ultrasonography: A National Cross‐Sectional Study

Contact Info

Product

Resources

About