Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

Dai, Chengjun; Wang, Chaoban; Xia, Fang-Qin; Liu, Zishuo; Mo, Yiqi; Shan, Xiaoou; Zhou, Yanfang

doi:10.3389/fped.2021.560720

Cited by 23 publications

(17 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Females and children whose mothers had high education levels were less likely to have hyperuricemia. The level of uric acid increased with age in children aged 5-14 years in southeast China [47]. One study showed that boys had higher mean serum uric acid concentrations than girls [19], and this difference was consistent with our results.…”

Section: Discussionsupporting

confidence: 91%

Multilevel Analysis of the Nutritional and Health Status among Children and Adolescents in Eastern China

et al. 2022

View full text Add to dashboard Cite

We aimed to identify multiple nutritional health problems and the relevant factors among children and adolescents aged 7–17 years. This study was part of the China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016–2017, conducted in Jiangsu Province in eastern China. After sampling, 3025 school-age children and adolescents were enrolled into this study. Demographic information collections and anthropometric measurements were conducted by trained local Center for Disease Control and Prevention (CDC) staff. Venous blood in the amount of 6 mL was drawn from each participant in the morning and used for testing biochemical and nutritional indicators. Multivariate logistic regression analysis and Poisson regression analysis were used for overnutrition- and undernutrition-related disorders to test relevant personal, parental, and household factors. The prevalence of wasting, overweight, and obesity was 5.5%, 14.8%, and 12.7%, respectively. Metabolic syndrome (MetS) was prevalent among 5.1% of participants. Among the study participants, 29.5% had hyperuricemia. The overall prevalence of high low-density lipoprotein (LDL) and high total cholesterol (TC) of all participants was 4.8% and 7.4%, respectively. 0.9% of the participants had vitamin A deficiency (VAD) and 14.6% had marginal vitamin A deficiency; 25.1% had vitamin D deficiency (VDD) and 54.5% had inadequate vitamin D levels. Anemia was present in 4.0% of all participants. The prevalence of zinc deficiency was 4.8%. Demographic characteristics, behavioral characteristics, parents’ characteristics, and family characteristics were associated with these multiple malnutrition disorders. The double burdens of malnutrition, which includes overnutrition- and undernutrition-related diseases, were prevalent among the school-age children and adolescents in Jiangsu Province in eastern China. There were various factors related to different nutritional problems. Thus, health education focusing on behavior intervention and nutrition education are necessary in containing nutritional problems among children.

show abstract

Section: Discussionsupporting

confidence: 91%

Multilevel Analysis of the Nutritional and Health Status among Children and Adolescents in Eastern China

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It has been reported that the levels of UA were similar between genders before puberty, but UA levels are higher in boys after puberty than in girls due to the action of sex hormones. It is generally believed that testosterone can inhibit the excretion of UA while estrogen can promote the excretion of UA ( 55 ). In our study, there was no statistical difference between genders.…”

Section: Discussionmentioning

confidence: 99%

Altered Gut Microbiota in Children With Hyperuricemia

et al. 2022

View full text Add to dashboard Cite

BackgroundIn adults, gut dysbiosis may contribute to the pathogenesis of gout. However, the characteristics of gut microbiota in children with hyperuricemia (HUA) in the absence of clinical gout have not been explored.ObjectiveThis present study analyzed the gut microbiota in children with HUA as compared to controls (Con) and explored bacterial associations that may account for differences.MethodsA total of 80 children were enrolled in this study; they were divided into HUA and Con according to the level of serum uric acid (UA). The composition of gut microbiota was investigated by 16S rRNA high-throughput sequencing.ResultsPrincipal coordinate analysis revealed that gut microbiota of the HUA group was clustered together and separated partly from the Con group. There was no difference in alpha-diversity between the two groups. However, Spearman’s correlation analysis revealed that serum UA level positively correlated with genera Actinomyces, Morganella, and Streptococcus, and negatively associated with the producers of short-chain fatty acids (SCFAs), such as Alistipes, Faecalibacterium, and Oscillospira, and the sulfidogenic bacteria Bilophila. The members of the genera Alistipes and Bilophila in the Con group were significantly more prevalent than the HUA subjects. Compared to the Con cohort, metabolic pathway predictions found that the superpathways of purine nucleotide de novo biosynthesis were decreased in HUA subjects, whereas the superpathway of purine deoxyribonucleoside de gradation was increased.ConclusionThe composition of the gut microbiota in children with HUA differs from Con. Although causality cannot be established, modification in the microbiota that produces SCFA and sulfide may promote HUA.

show abstract

“…In childhood, high values of UA are in uenced by ethnicity, age and sex, so a universal de nition of abnormal UA levels is lacking. In non-obese youths values above 6 or 7 mg/dL in boys and 5 or 6 mg/dL in girls were previously been considered "elevated" [18,19].…”

Section: Discussionmentioning

confidence: 99%

Uric acid and cardiometabolic risk profile in youths with type 1 diabetes: sex-related associations

Bonito¹,

Rosanio

Marcovecchio

et al. 2022

Preprint

View full text Add to dashboard Cite

The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youths with type 1 diabetes (T1D). Retrospective data collected from 1323 youths (5-18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA1c, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). The distribution of CMRFs was analyzed in sex-specific tertiles of UA. In the whole study population, statistically significant differences were found across UA tertiles for age, BMI, daily insulin dose, HbA1c, HDL, TG, TG/HDL ratio, TC/HDL ratio, SPISE index, N/L ratio, systolic BP, eGFR (p =0.01-0.0001). The highest tertile of UA was associated with 1,5-3,6 fold increased risk of high TG/HDL ratio, TC/HDL ratio, high BP, and MRGFR, compared to the lowest tertile in boys. Instead, in girls the highest tertile of UA was associated with two-fold increased risk of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and association appears to vary by sex.

show abstract

Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

Cited by 23 publications

References 18 publications

Multilevel Analysis of the Nutritional and Health Status among Children and Adolescents in Eastern China

Multilevel Analysis of the Nutritional and Health Status among Children and Adolescents in Eastern China

Altered Gut Microbiota in Children With Hyperuricemia

Uric acid and cardiometabolic risk profile in youths with type 1 diabetes: sex-related associations

Contact Info

Product

Resources

About