Age and sex differences in microRNAs expression during the process of thymus aging

Guo, Dongguang; Ye, Yaqiong; Qi, Junjie; Tan, Xiaojie; Zhang, Yuan; Ma, Yue; Li, Yugu

doi:10.1093/abbs/gmx029

Cited by 33 publications

(21 citation statements)

References 60 publications

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“…MicroRNAs (miRNAs) may be considered as potential biomarkers for the study of sex-and age-related differences in involution of the thymus. 15 In albino rats, of both sexes, no significant sex-differences were observed in fibronectin immunolocalization and in the histology of the thymus. In these animals, there were agerelated increases in the fibronectin content in the thymic capsule, the interlobular connective tissue, the perivascular tissue, and in the medulla and cortex.…”

Section: Aging and Thymus Glandmentioning

confidence: 94%

Aging of thymus gland and immune system

Haroun¹

2018

MOJAP

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Aging is an inevitable, progressive and irreversible process that is manifested with multiple organ dysfunction. Reactive oxygen species (ROS) is considered the main etiological factor of aging. The thymus gland is the primary site of T cell production and it represents a key organ of the immune system. It is endodermal in origin and lies in the anterior mediastinum behind the sternum. Thymic involution with aging results in less efficient T-cell development and decreased emigration of naïve T cells to the periphery. Deterioration of the immune system with aging contributes to increased incidence of infection, autoimmunity, and cancer, thus increasing the rates of morbidity and mortality in elderly humans.

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Section: Aging and Thymus Glandmentioning

confidence: 94%

Aging of thymus gland and immune system

Haroun¹

2018

MOJAP

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“…Despite the important role of the thymus, it undergoes involution during the ageing process in humans and most mammals . The age‐related changes observed in the thymus are generally associated with a dramatic decrease in its size and structural complexity, characterized by the loss of thymocytes and TECs.…”

Section: Introductionmentioning

confidence: 99%

Integrated microRNA and mRNA sequencing analysis of age‐related changes to mouse thymic epithelial cells

et al. 2018

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MicroRNAs (miRNAs) play key roles in the regulation of gene expression during multiple physiological processes, including early development, differentiation, and ageing. However, their involvement in age-related thymic involution is not clear. In this study, we profiled the global transcriptome and miRNAome of thymic epithelial cells in 1- and 3-month-old male and female mice, and predicted the possible transcription factors and target genes of the four most significantly differentially expressed miRNAs (DEMs) (miR-183-5p, miR-199b-5p, miR-205-5p, and miR-200b-3p) by performing bioinformatics analyses. We also evaluated the relationships between the significantly DEMs and mRNAs. We performed quantitative polymerase chain reaction to confirm the changes in the expression of the miRNAs and their predicted target genes. We found that miR-183-5p, miR-199b-5p, miR-205-5p, and miR-200b-3p can be used as a biomarker group for mouse thymus development and involution. In addition, the predicted target genes (Ptpn4, Slc2a9, Pkib, Pecam1, and Prkdc), which were identified by mRNA sequencing analysis, were mainly involved in growth, development, and accelerated senescence. In conclusion, miRNAs and their predicted target genes likely play important roles in thymus development and involution. To the best of our knowledge, this is the first study to systematically analyze the relevance of miRNAs and their targets by mRNA sequencing in mouse thymic epithelial cells. © 2018 IUBMB Life, 70(7):678-690, 2018.

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“…In our study, the logistic regression results also show that females tend to EH more strongly than males. In comparison with males, the downregulation of vascular-related miRNAs in females may be associated with the rate of thymus aging, menstrual cycle, chronic inflammation, and physical activity level [Tritten et al, 2016;Guo et al, 2017;Kwekel et al, 2017]. However, the mechanism of the sexrelated different expression remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension

Liu¹,

Gu²,

Bao³

et al. 2019

Cytogenet Genome Res

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Essential hypertension (EH), a major cause of cardiovascular diseases, is an important public health issue. However, the molecular mechanisms involved in EH remain unknown. Circular RNA (circRNA) is a novel promising biomarker for the disease. The purpose of the present study was to determine the expression of circRNAs in the blood of EH patients and to evaluate the performance of circRNA for early diagnosis of EH. A total of 178 subjects were recruited in the case-control study. Initial screening was done by using the Agilent human circRNA microarray followed by qRT-PCR validation. Finally, miRNAs were combined with circRNAs to create a new early prediction model for EH. The expression level of hsa_circ_0126991 in EH patients was significantly higher in comparison with healthy controls (p < 0.0001). Using the interaction of miR-10a-5p in combination with hsa_circ_0126991 led to a sensitivity of 0.708, a specificity of 0.764, and combined area under the curve of 0.774 (95% CI: 0.705-0.843) for early diagnosis of EH. In summary, the present study uncovered a novel perspective that hyperexpression of hsa_circ_0126991 is correlated with the risk of EH and may serve as a stable biomarker for early diagnosis of EH.

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Age and sex differences in microRNAs expression during the process of thymus aging

Cited by 33 publications

References 60 publications

Aging of thymus gland and immune system

Aging of thymus gland and immune system

Integrated microRNA and mRNA sequencing analysis of age‐related changes to mouse thymic epithelial cells

Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension

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