Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism

Haag, Markus; Hamann, Tina; Kulle, Alexandra; Riepe, Felix G.; Blatt, Thomas; Wenck, Horst; Holterhus, Paul‐Martin; Peirano, Reto I.

doi:10.4161/derm.19201

Cited by 8 publications

(4 citation statements)

References 38 publications

(50 reference statements)

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“…Sebocytes can synthesize de novo cholesterol from acetate [36,37] and possess enzymatic machinery to produce sex steroids as well as glucocorticoids [38]. Confluent immortalized sebocytes [39] but not fibroblasts or keratinocytes express the enzyme 3β-HSD 1, which is responsible for the catalyzation of androstenedione from DHEA, as the first step for in situ testosterone formation. Hydrolysis of the circulating DHEA-S to DHEA through steroid sulfatase, takes mainly place in the sebaceous gland and the terminal hair follicle.…”

Section: Hs and The Pilosebaceous Unitmentioning

confidence: 99%

Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder?

Karagiannidis

Nikolakis

Sabat

et al. 2016

Rev Endocr Metab Disord

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Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis. Furthermore, the common comorbidity with metabolic syndrome points to possible interactions between endocrinological and metabolic alterations in the development of HS. Taking into account the endocrine functions of the human skin, several studies investigated the effects of hormones and the behavior of the pilosebaceous unit in the skin of patients with HS. In this review we describe the current view on the hormonal dysregulation and metabolic syndrome and their role in HS.

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Section: Hs and The Pilosebaceous Unitmentioning

confidence: 99%

Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder?

Karagiannidis

Nikolakis

Sabat

et al. 2016

Rev Endocr Metab Disord

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“…The normal skin development and function is influenced by hormones: for example, the growth hormone stimulates keratinocyte proliferation [ 39 ], and thyroid hormones act directly on hair follicles [ 40 ]. The skin is a neuroendocrine organ, capable of hormone synthesis and release [ 41 ]: corticosteroids and sex hormones are synthesized and transformed [ 42 ] (with sebocytes playing a central role in cutaneous androgen metabolism [ 43 ]); catecholamines are synthesized by keratinocytes and melanocytes [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

The role of hormones in the pathogenesis of psoriasis vulgaris

Roman

Constantin

Marina

et al. 2015

Medicine and Pharmacy Reports

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Psoriasis vulgaris is a chronic, common skin disease, which affects the patient’s quality of life to the highest degree. Several exogenous factors and endogenous hormonal changes may act as triggers for psoriasis.The skin possesses a true endocrine system, which is very important in multiple systemic diseases. A number of conditions are associated with psoriasis, and its severity can also be influenced by hormones. Even though the sex hormones and prolactin have a major role in psoriasis pathogenicity, there are a lot of other hormones which can influence the psoriasis clinical manifestations: glucocorticoids, epinephrine, thyroid hormones, and insulin.

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“…In the following paper, Marina Rodriguez-Martin et al 10 discuss the question When are laboratory tests indicated in patients with vitiligo? In the next laboratory contribution, Markus Haag et al 11 investigate age and skin site related differences in steroid metabolism in male skin that point to a key role of sebocytes in cutaneous hormone metabolism. In the following clinical paper, Gerhard Lutz 12 reports on the association of Hair loss and hyperprolactinemia in women.…”

mentioning

confidence: 99%