Age and Vitamin E-Induced Changes in Gene Expression Profiles of T Cells

Han, Sung Nim; Adolfsson, Oskar; Lee, Cheol Koo; Prolla, Tomas A.; Ordovás, José M.; Meydani, Simin Nikbin

doi:10.4049/jimmunol.177.9.6052

Cited by 64 publications

(54 citation statements)

References 40 publications

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“…is is in contrast to studies done by other groups [9,12,47]; however, higher levels of vita- [16][17][18]. Epidemiological reports and dose-response studies on animals showed that the infectious dose for L. monocytogenes can be low.…”

Section: Discussioncontrasting

confidence: 54%

Immune Status and the Development of Listeria monocytogenes Infection in Aged and Young Guinea Pigs

Pang²,

Matthews³

2012

CIM

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Purpose: Consuming even low numbers of the foodborne pathogen, Listeria monocytogenes, places the elderly at risk for severe illness. e impact of immunomodulation on the development of listerial infection within a young and aged population a er low dose challenge with L. monocytogenes was investigated.Methods: Animals received daily supplementation of vitamin E for a period of 21 days to promote immunomodulation, and were then orally challenged with 100 CFU of L. monocytogenes. Levels of CD8 + , CD4 + and CD3 + T cells were used as markers to determine the in uence of daily supplementation with vitamin E on immune response; the spleen and liver were harvested for microbiological analysis.Results: Higher numbers of animals became infected in control groups than in vitamin Etreated group. During the post-challenge period, vitamin E-treated aged animals showed faster CD8 + T cell proliferation than control aged animals. Conclusion:Daily supplementation with vitamin E was more bene cial in young compared with aged animals in mitigating listerial infection. Results suggest exposure to even low numbers of L. monocytogenes can result in infection in both healthy young and aged populations.

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Section: Discussioncontrasting

confidence: 54%

Immune Status and the Development of Listeria monocytogenes Infection in Aged and Young Guinea Pigs

Pang²,

Matthews³

2012

CIM

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“…The antioxidant activity is due not only to the de-activation of free radicals produced by the decomposition of lipid hydroperoxides, but also to the inhibition of lipid hydroperoxide decomposition (Pokorny and Parkányiová, 2005;Makinen et al, 2001). In addition, previous studies have shown that tocopherols have substancial health benefits such as hypocholesteremic, hypolipidemic, anticancer, antiinflamatory and antioxidant properties and slow down the aging process (Ghaffari et al, 2011;Singh and Devaraj 2007;Hau et al, 2006).…”

Section: Tocopherolsmentioning

confidence: 99%

Amazonian Buriti oil: chemical characterization and antioxidant potential

et al. 2016

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SUMMARY:Buriti oil is an example of an Amazonian palm oil of economic importance. The local population uses this oil for the prevention and treatment of different diseases; however, there are few studies in the literature that evaluate its properties. In this study, detailed chemical and antioxidant properties of Buriti oil were determined. The predominant fatty acid was oleic acid (65.6%) and the main triacylglycerol classes were tri-unsaturated (50.0%) and di-unsaturated-mono-saturated (39.3%) triacylglycerols. The positional distribution of the classes of fatty acids on the triacylglycerol backbone indicated a saturated and unsaturated fatty acid relationship similar in the three-triacylglycerol positions. All tocopherol isomers were present, with a total content of 2364.1 mg·kg −1 . α-tocopherol constitutes 48% of the total tocopherol content, followed by γ-tocopherol (45%). Total phenolic (107.0 mg gallic acid equivalent·g −1 oil) and β-carotene (781.6 mg·kg −1 ) were particularly high in this oil. The highest antioxidant activity against the free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) was obtained at an oil concentration of 50 mg·mL −1 (73.15%). The antioxidant activity evaluated by the Oxygen Radical Absorbance Capacity (ORAC) was 95.3 μmol Trolox equivalent·g −1 oil. These results serve to present Buriti oil as an Amazonian resource for cosmetic, food and pharmaceuticals purposes. KEYWORDS: Fatty acid; Minor compound; Radical scavenging activity; Regio-specific distribution; TriacylglycerolRESUMEN: Aceite de buriti de la Amazonia: Caracterización química y potencial antioxidante. El aceite de Buriti es un ejemplo de aceite de palma amazónica de gran importancia económica. La población local utiliza este aceite para la prevención y el tratamiento de diferentes enfermedades; sin embargo, hay pocos estudios científicos que evalúen sus propiedades. En este estudio, se determinaron las propiedades antioxidantes del aceite de Buriti. El ácido graso predominante fue el oleico (65,6 %) y las principales clases de triglicéridos fueron tri-insaturadas (50,0 %) y Di-insaturados-mono-saturada (39,3 %). La distribución posicional de las clases de ácidos grasos en el esqueleto de triacilglicerol indicó una relación de ácidos grasos saturados e insaturados similar en las tres posiciones del triacilglicerol. Todas las isoformas de tocoferol estaban presentes, con un contenido total de 2364.1 mg·kg ) fueron particularmente altos en este aceite. La mayor actividad antioxidante contra el radical 1,1-difenil-2-picrilhidrazil libre (DPPH) se obtuvo a una concentración de aceite de 50 mg·mL −1 (73,15 %). La actividad antioxidante evaluadas por la capacidad de absorción de radicales de oxígeno (ORAC) fue 95,3 mmol Trolox equivalente·g −1 de aceite. Estos resultados presentan al aceite de Buriti amazónico como buen recurso con fines cosmético, alimenticio y farmacéutico.

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“…Vitamin E has been shown to improve T cell functions in the old. It is reported that gene expression profiles of T cells to better understand the underlying mechanisms of age and vitamin E-induced changes in T cell function (129). According to performed experiments with young and old C57BL mice, 500 ppm of vitamin E supplementation for 4 wks resulted in higher expression of genes involved in cell cycle regulation (Ccnb2, Cdc2, Cdc6) in old T cells.…”

Section: Steroidmentioning

confidence: 99%

“…According to performed experiments with young and old C57BL mice, 500 ppm of vitamin E supplementation for 4 wks resulted in higher expression of genes involved in cell cycle regulation (Ccnb2, Cdc2, Cdc6) in old T cells. Gene expression profiles of T cells were assessed utilizing microarray analysis with/without anti-CD3/anti-CD28 stimulation (129). It has found that vitamin E supplementation resulted in higher up-regulation of IL-2 expression in young and old T cells whereas lower up-regulation of IL-4 expression in old T cells following stimulation and also resulted in higher up-regulation of IL-2 expression in young and old T cells whereas lower up-regulation of IL-4 expression in old T cells following stimulation (129).…”

Section: Steroidmentioning

confidence: 99%

“…Gene expression profiles of T cells were assessed utilizing microarray analysis with/without anti-CD3/anti-CD28 stimulation (129). It has found that vitamin E supplementation resulted in higher up-regulation of IL-2 expression in young and old T cells whereas lower up-regulation of IL-4 expression in old T cells following stimulation and also resulted in higher up-regulation of IL-2 expression in young and old T cells whereas lower up-regulation of IL-4 expression in old T cells following stimulation (129). It has suggested that aging has significant effects regarding the gene expression associated with signal transduction, transcriptional regulation and apoptosis pathways in T cells and vitamin E has a significant impact concerning the gene expression associated with cell cycle and Th1/Th2 balance in old T cells (129).…”

Section: Steroidmentioning

confidence: 99%

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Most fortificated nutraceutical vitamins: standpoint from biochemistry, functionality, utilization strategies and medical genomics

Tokuşoğlu

Müezzinoğlu

2015

Natural Science and Discovery

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Nutraceutical vitamins are micronutrients of foods and beverages that play an essential role in food science and technology. Most fortificated vitamin A, E, D and folic acid as antioxidative defence system components and that of with gene regulation functions have been considered. Up-to-date scientific overview of the biochemistry, functionality, utilization strategies and human genomics of above-mentioned most fortificated nutraceutical vitamins were emphasized

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Age and Vitamin E-Induced Changes in Gene Expression Profiles of T Cells

Cited by 64 publications

References 40 publications

Immune Status and the Development of Listeria monocytogenes Infection in Aged and Young Guinea Pigs

Immune Status and the Development of Listeria monocytogenes Infection in Aged and Young Guinea Pigs

Amazonian Buriti oil: chemical characterization and antioxidant potential

Most fortificated nutraceutical vitamins: standpoint from biochemistry, functionality, utilization strategies and medical genomics

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