Age-Appropriate Pediatric Dosage Forms in Japan: Insights into End-User Perceptions From an Observational Cross-Sectional Survey Assessing the Acceptability of Oral Formulation

Saito, Jumpei; Akabane, Miki; Komura, Makoto; Nakamura, Hidefumi; Ishikawa, Yoichi

doi:10.1177/2168479018791133

Cited by 11 publications

(5 citation statements)

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“…') by drug type and dosage the capsule in this survey based on available antivirals in market. The size of oral drugs is reportedly an important factor when choosing treatments for children [7,17,18], which is associated with higher preference for tablet in previous reports from Japan [18] and the United Kingdom [17]. Our survey results indicate that difficulty swallowing the drug was the most frequent reason children had trouble taking both capsules and tablets and the percentage was larger for capsules than for tablets (21.7% vs. 16.3%).…”

Section: Discussionmentioning

confidence: 53%

“…Different preferences were observed among the oral drugs; capsules and dry syrup were less preferred, whereas tablets were preferred over inhalants. While the administration route, oral and inhalant, has been compared in a previous study for adults [5], the current study also looked at the type of formulation in addition to administration route, because formulation is considered an important factor affecting acceptability in pediatric patients [6,7,[16][17][18]. One of the reasons for the higher preference for tablets than capsules may be associated with its size, which was set smaller for the tablet than Fig.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Inconvenience Costs Between Influenza Antivirals for Japanese Pediatric Patients: A Conjoint Analysis of Parental Responses

et al. 2022

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Introduction: Certain drug characteristics, including dosage and form, are associated with either convenience or inconvenience for the patients taking them, and any inconvenience can be considered as a ''cost'' in disease treatment. Multiple antivirals are available for influenza in Japan, with various dosages and forms. This study evaluated the inconvenience costs associated with influenza antivirals for pediatric patients by using conjoint analysis on responses from their parents. Methods: An online survey (May 2021) was conducted for parents whose child took antivirals for influenza at 6-11 years during the 3 years until March 2021. Attributes of the

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Comparison of Inconvenience Costs Between Influenza Antivirals for Japanese Pediatric Patients: A Conjoint Analysis of Parental Responses

et al. 2022

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“…In further study in Japan, it may be better to advise caregivers to administer multiple minitablets all at once. As reported by Saito et al [17], parents and nurses often dissolve or disperse powder formulations in water for children. Alessandrini et al also reported that liquid formulations were widely selected by children less than 12 years and granules were not appreciated, particularly by adolescents [18].…”

Section: Discussionmentioning

confidence: 99%

Swallowability of Minitablets among Children Aged 6–23 Months: An Exploratory, Randomized Crossover Study

et al. 2022

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Minitablets have garnered interest as a new paediatric formulation that is easier to swallow than liquid formulations. In Japan, besides the latter, fine granules are frequently used for children. We examined the swallowability of multiple drug-free minitablets and compared it with that of fine granules and liquid formulations in 40 children of two age groups (n = 20 each, aged 6–11 and 12–23 months). We compared the percentage of children who could swallow minitablets without chewing with that of children who could swallow fine granules or liquid formulations without leftover. The children who visited the paediatric department of Showa University Hospital were enrolled. Their caregivers were allowed to choose the administration method. In total, 37 out of 40 caregivers dispersed the fine granules in water. Significantly more children (80%, 95% CI: 56–94%) aged 6–11 months could swallow the minitablets than those who could swallow all the dispersed fine granules and liquid formulations (22%, 95% CI: 6–47% and 35%, 95% CI: 15–59%, respectively). No significant differences were observed in children aged 12–23 months. Hence, minitablets may be easier to swallow than dispersed fine granules and liquid formulations in children aged 6–11 months.

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“…The pediatric population may also prefer nonsolid oral dosage forms for easier ingestion. 56 Liquid formulations allow more precise dosing to maximize efficacy and decrease AEs. Moreover, age-related health complications in the older patients, such as dysphagia, may require alternate or modified dosage forms.…”

Section: Safety Considerations/adverse Effectsmentioning

confidence: 99%

Zonisamide

Gidal,

Resnick,

Smith

et al. 2024

Neur Clin Pract

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Purpose of ReviewZonisamide (ZNS) was first approved in the United States in 2000 for the adjunctive treatment of patients aged 16 years or older with partial (focal) seizures. Although ZNS has been proven to treat multiple seizure types, it has been largely underutilized in US clinical practice.Recent FindingsPublished literature demonstrated that antiseizure medications (ASMs) acting on Na+and Ca2+channels may add beneficial effects in many seizure types by reducing seizure frequency and leading to overall improvements. In addition, effects of ZNS may lead to clinical improvements in Parkinson disease, alcohol and sleep disorders, pain, and migraine. ZNS is available in multiple formulations and is a safe and effective, broad spectrum ASM.SummaryThe purpose of this review was to provide an update to what is known about the efficacy of ZNS and where it shows benefits in the treatment of patients with epilepsy and other CNS disorders through its many unique mechanisms of action.

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Age-Appropriate Pediatric Dosage Forms in Japan: Insights into End-User Perceptions From an Observational Cross-Sectional Survey Assessing the Acceptability of Oral Formulation

Abstract: The difference in caregivers' perception of the acceptability of oral formulations between Japan and Europe was small. The powder form was found to be more acceptable in Japan. Further intervention studies are needed to assess the preferred pediatric formulation worldwide.

Cited by 11 publications

References 22 publications

Comparison of Inconvenience Costs Between Influenza Antivirals for Japanese Pediatric Patients: A Conjoint Analysis of Parental Responses

Comparison of Inconvenience Costs Between Influenza Antivirals for Japanese Pediatric Patients: A Conjoint Analysis of Parental Responses

Swallowability of Minitablets among Children Aged 6–23 Months: An Exploratory, Randomized Crossover Study

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