Age as a cause of chronic mountain sickness (Monge's disease)

Sime, Francisco; Monge, Carlos; Whittembury, J

doi:10.1007/bf01463864

Cited by 50 publications

(27 citation statements)

References 6 publications

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“…Although PH is an essential feature of chronic mountain sickness (or Monge disease), children are seldom affected. 554 In contrast, HAPE and symptomatic high-altitude PH (SHAPH) affect infants and children as well as adults.…”

Section: Hypobaric Hypoxia and High Altitude-related Illnessesmentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

949

405

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Abstract-Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patients with pulmonary hypertension have been limited by the lack of consensus guidelines from experts in the field. In a joint effort from the American Heart Association and American Thoracic Society, a panel of experienced clinicians and clinician-scientists was assembled to review the current literature and to make recommendations on the diagnosis, evaluation, and treatment of pediatric pulmonary hypertension. This publication presents the results of extensive literature reviews, discussions, and formal scoring of recommendations for the care of children with pulmonary hypertension. Key Words: AHA Scientific Statements ◼ bronchopulmonary dysplasia ◼ congenital diaphragmatic hernia ◼ congenital heart disease ◼ genetics ◼ persistent pulmonary hypertension of the newborn ◼ sickle cell disease © 2015 by the American Heart Association, Inc., and the American Thoracic Society.Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0000000000000329 †Deceased. The American Heart Association and the American Thoracic Society make every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This document was approved by the American Heart Association Science Advisory and Coordinating Committee on May 12, 2015, the American Heart Association Executive Committee on July 22, 2015, and the American Thoracic Society on July 24, 2015.The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000329/-/DC1. The American Heart Association requests that this document be cited as follows: Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; on behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia, and the American Thoracic Society. Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation. 2015;132:2037-2099 Copies: This document is available on the World Wide Web site of the American Heart Associat...

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Section: Hypobaric Hypoxia and High Altitude-related Illnessesmentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

949

405

View full text Add to dashboard Cite

show abstract

“…4,6,24,25 Our study also identifi ed potentially new risk factors for EE, including having metabolic syndrome and a decreased vital capacity. Th e former is consistent with previous studies that have reported both altered lipid profi les and glucose metabolism in high-altitude dwellers.…”

Section: Discussionmentioning

confidence: 72%

Prevalence, Clinical Profile, Iron Status, and Subject-Specific Traits for Excessive Erythrocytosis in Andean Adults Living Permanently at 3,825 Meters Above Sea Level

Ferrari

Miranda

Gilman

et al. 2014

Chest

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“…This may be due to the nature of the sickness. AMS occurs in climbers within a few days of arrival at high altitudes and therefore may involve fewer affected genes then found in patients with CMS, which is an illness that manifests its self with age [37,38] and thereby reflects a broader array of genes. Eight of the first nine miRNAs in the AMS patients upregulate either angiogenesis or hypoxia genes where the most down regulated miRNA (miR-195-5p) also regulates hypoxia genes ( Table 2, Supplements 1 and 2) which possibility counter balances the upregulation surge in hypoxia genes.…”

Section: Resultsmentioning

confidence: 99%

Circulating miRNAs from Dried Blood Spots are Associated with High Altitude Sickness

Buroker

Ning²,

Zhou³

et al. 2013

J Med Diagn Meth

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Circulating miRNAs isolated from dried blood spots (DBS) were found to be associated with high altitude sickness (HAS) patients in Tibet. HAS arises from two different diseases which are acute (AMS) and chronic (CMS) mountain sickness. Circulating miRNAs differences were found between AMS Han Chinese patients and normal Han controls and between CMS Tibetan Chinese patients and normal Tibetan controls. HAS arises from hypoxia which afflicts some high altitude inhabitants or visitors and not others. The difference results from each individual's genetic makeup where hypoxia related genes have been shown to be a major contributor to these sicknesses. Several fold changes increases (up regulation) were found in the hypoxia associated miRNAs let-7f-5p, miR-9-5p, miR-19a-3p, miR-23a-3p, miR-98-5p, miR-125a-5p, miR-181b-5p, mir-202-3p, miR-372, miR-381-3p, miR-519d, miR-520d-3p, and miR-656 for both HAS groups compared to their controls. Other miRNAs (miR-19a-3p, 302c-3p and 875-3p) were found to be up regulated in one HAS group and down regulated in the other HAS group indicating the genetic differences between the two sickness groups.

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Age as a cause of chronic mountain sickness (Monge's disease)

Cited by 50 publications

References 6 publications

Pediatric Pulmonary Hypertension

Pediatric Pulmonary Hypertension

Prevalence, Clinical Profile, Iron Status, and Subject-Specific Traits for Excessive Erythrocytosis in Andean Adults Living Permanently at 3,825 Meters Above Sea Level

Circulating miRNAs from Dried Blood Spots are Associated with High Altitude Sickness

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