Age associated decrease of sialin in salivary glands

Li, L; Wang, H; Hu, Lei; Wu, Xiaoshan; Zhao, Bi; Fan, Zhipeng; Zhang, C; Wang, J; Wang, S

doi:10.1080/10520295.2018.1463453

Cited by 18 publications

(12 citation statements)

References 22 publications

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“…For example, in rodents the effects of dietary NO3are more prominent in fast-vs. slow-twitch muscle (4,5), and some (25,26), but not all (27), studies of humans have found that aging results in a reduction in the percentage of fast-twitch muscle fibers. Alternatively and/or in addition, an age-related decrease in the ability of salivary glands to concentrate NO3 - (28) or more rapid destruction of NO due to increased production of reactive oxygen species in aged muscle (29,30) could limit the beneficial effects of dietary NO3in older persons.…”

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confidence: 99%

A single dose of dietary nitrate increases maximal muscle speed and power in healthy older men and women

Coggan

Hoffman

Gray

et al. 2019

Preprint

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Background Aging results in reductions in maximal muscular strength, speed, and power, which often lead to functional limitations highly predictive of disability, institutionalization, and mortality in the elderly. This may be partially due to reduced nitric oxide (NO) bioavailability. We therefore hypothesized that dietary nitrate (NO3 -), a source of NO via the NO3 -→ nitrite (NO2 -) → NO enterosalivary pathway, could increase muscle contractile function in older subjects.Methods Twelve healthy older (age 71±1 y) subjects were studied using a randomized, doubleblind, placebo-controlled, crossover design. After fasting overnight, subjects were tested 2 h after ingesting beetroot juice containing or devoid of 13.4±0.5 mmol NO3 -. Plasma NO3and NO2and breath NO were measured periodically, and muscle function was determined using isokinetic dynamometry.Results NO3ingestion increased (P<0.001) plasma NO3 -, plasma NO2 -, and breath NO by 1050%, 140%, and 110%, respectively. Maximal velocity of knee extension increased (P<0.01) by 1.1±0.3 rad/s, or by 10.9±3.5%. Maximal knee extensor power increased (P<0.05) by 0.14±0.06 W/kg, or by 4.4±2.3%.Conclusions Acute dietary NO3intake improves muscle contractility in older individuals. These findings have important implications for this population, in whom diminished muscle function can lead to functional limitations, dependence, and even premature death.

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mentioning

confidence: 99%

A single dose of dietary nitrate increases maximal muscle speed and power in healthy older men and women

Coggan

Hoffman

Gray

et al. 2019

Preprint

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“…One of these proteins is sialin, a small peptide produced by parotids with an alkalinizing effect that contributes to the increased oral pH. The production of this peptide decreases with aging, 25 and although we have not measured the concentration of sialin in saliva, we suggest that a decrease in salivary pH with aging is associated with a decrease in the amount of sialin in saliva. Another factor that is associated with reduced salivary flow is a higher BMI.…”

Section: Discussionmentioning

confidence: 69%

Salivary pH and oral health of Brazilian para‐athletes: Saliva and oral health of para‐athletes

Brancher

Morodome

Madalena

et al. 2021

Special Care in Dentistry

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Aims This study aimed to investigate the association of the salivary pH and parameters of oral health in Brazilian para‐athletes. Methods and results The sample was composed of 271 Brazilian para‐athletes (147 athletics, 61 powerlifting, and 63 swimming); mean age was 31.2 ± 11.7 years. Data collected during anamnesis, clinical examination, and saliva collection revealed that salivary pH was different among sports (p = .01) and tends to decrease as age and body mass index (BMI) increase (p = .026, .027, respectively). The mean decay missing filled teeth was 8.8 (±0.57), but there is no correlation with salivary pH (R2 = −0.0852; CI 95%, −0.215–0.047; p = .194) as habits of grinding, clenching teeth, or bruxism was not associated with salivary pH (p = .317, .932, and .444, respectively). Regarding breathing, para‐athletes that have buccal breathing had significantly higher salivary pH (p = .04). This data were confirmed by multiple logistic regression (p = .05). Open bite, lip seal, geographic or fissured tongue also were not associated with variation of salivary pH (p > .05). Conclusions This study provided evidence of an association between salivary pH with age, BMI, type of breathing, and type of sport practiced by the para‐athletes

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“…Sialin is a versatile anion transporter expressed in salivary glands [258] that transports glutamate, NO 3 − , and other anions from blood to saliva. We hypothesize that salivary epithelium sequesters the PSMA ligands by uptake through the sialin anion/ H + symporter on the basolateral side of these cells but is not able to secrete the ligands into the saliva at the apical side.…”

Section: Introductionmentioning

confidence: 99%

“…In support of this hypothesis, sialin transports NAAG and a variety of glutamate containing xenobiotics, as well as NO 3 − and glutamate, into epithelial cells [259] , [260] , [261] . Salivary glands also express the most sialin in mammals [258 , 261] whereas the other conduit for PSMA ligand uptake, PSMA, is expressed at very low levels in these glands [10 , 36 , 89] . Moreover, PSMA expression is restricted to intercalated epithelium of these glands [36] .…”

Section: Introductionmentioning

confidence: 99%