Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body

Gehring, Katrin B.; Heufelder, Karin; Depner, Harald; Kersting, Isabella; Sigrist, Stephan J.; Eisenhardt, Dorothea

doi:10.1371/journal.pone.0175894

Cited by 7 publications

(5 citation statements)

References 58 publications

(87 reference statements)

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“…It turns out that the presynaptic AZs in the MB calyx become larger during ageing, as measured in EM images of the calycal AZs and after super-resolution imaging of the localization of BRP [ 138 ]. Interestingly, a similar increase in BRP accumulation was observed in bees as well [ 139 ]. The increased size of AZs correlated with augmented SV release.…”

Section: Plasticity During Adult Life and Ageingsupporting

confidence: 71%

Structural aspects of plasticity in the nervous system of Drosophila

2018

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Neurons extend and retract dynamically their neurites during development to form complex morphologies and to reach out to their appropriate synaptic partners. Their capacity to undergo structural rearrangements is in part maintained during adult life when it supports the animal’s ability to adapt to a changing environment or to form lasting memories. Nonetheless, the signals triggering structural plasticity and the mechanisms that support it are not yet fully understood at the molecular level. Here, we focus on the nervous system of the fruit fly to ask to which extent activity modulates neuronal morphology and connectivity during development. Further, we summarize the evidence indicating that the adult nervous system of flies retains some capacity for structural plasticity at the synaptic or circuit level. For simplicity, we selected examples mostly derived from studies on the visual system and on the mushroom body, two regions of the fly brain with extensively studied neuroanatomy.

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Section: Plasticity During Adult Life and Ageingsupporting

confidence: 71%

Structural aspects of plasticity in the nervous system of Drosophila

2018

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“…In both cases, this effect on BRP levels is accompanied by a partial compensation for memory decline. This is consistent with previous findings showing that maintaining adaptive levels of BRP expression is necessary for proper memory function in flies ( 21 , 44 ) and arguably in bees as well ( 45 ). Why might BRP levels matter for memory function?…”

Section: Discussionsupporting

confidence: 93%

Memory enhancement by ferulic acid ester across species

et al. 2018

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“…They die about 6 weeks after emersion. Honeybee brain anatomy [ 164 ] and the expression levels of certain proteins like CREB [ 165 ], bruchpilot [ 166 ] vitellogenin [ 167 ], synapsin [ 168 ] or neuropeptides [ 169 ] vary with age and experience. Seasonal changes in gene expression were also observed [ 170 – 172 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization

et al. 2018

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BackgroundFoxP transcription factors play crucial roles for the development and function of vertebrate brains. In humans the neurally expressed FOXPs, FOXP1, FOXP2, and FOXP4 are implicated in cognition, including language. Neural FoxP expression is specific to particular brain regions but FoxP1, FoxP2 and FoxP4 are not limited to a particular neuron or neurotransmitter type. Motor- or sensory activity can regulate FoxP2 expression, e.g. in the striatal nucleus Area X of songbirds and in the auditory thalamus of mice. The DNA-binding domain of FoxP proteins is highly conserved within metazoa, raising the possibility that cellular functions were preserved across deep evolutionary time. We have previously shown in bee brains that FoxP is expressed in eleven specific neuron populations, seven tightly packed clusters and four loosely arranged groups.ResultsThe present study examined the co-expression of honeybee FoxP (AmFoxP) with markers for glutamatergic, GABAergic, cholinergic and monoaminergic transmission. We found that AmFoxP could co-occur with any one of those markers. Interestingly, AmFoxP clusters and AmFoxP groups differed with respect to homogeneity of marker co-expression; within a cluster, all neurons co-expressed the same neurotransmitter marker, within a group co-expression varied. We also assessed qualitatively whether age or housing conditions providing different sensory and motor experiences affected the AmFoxP neuron populations, but found no differences.ConclusionsBased on the neurotransmitter homogeneity we conclude that AmFoxP neurons within the clusters might have a common projection and function whereas the AmFoxP groups are more diverse and could be further sub-divided. The obtained information about the neurotransmitters co-expressed in the AmFoxP neuron populations facilitated the search of similar neurons described in the literature. These comparisons revealed e.g. a possible function of AmFoxP neurons in the central complex. Our findings provide opportunities to focus future functional studies on invertebrate FoxP expressing neurons. In a broader context, our data will contribute to the ongoing efforts to discern in which cases relationships between molecular and phenotypic signatures are linked evolutionary.

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Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body

Cited by 7 publications

References 58 publications

Structural aspects of plasticity in the nervous system of Drosophila

Structural aspects of plasticity in the nervous system of Drosophila

Memory enhancement by ferulic acid ester across species

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization

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