Age at diagnosis indicated poor prognosis in locoregionally advanced nasopharyngeal carcinoma

Abstract

Background: Effect of age at diagnosis on treatment failure and mortality was

Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004‐2013

“…These differences in outcomes for older patients can likely be attributed in some part to an increased burden of co-morbid disease, 28,36 which could allow a tumour to metastasise more freely. 37 In the light of our finding that Chinese ethnicity is associated with shorter OS and NPCSS among older patients in the US, we suggest that other factors may have as strong influence on outcomes as do comorbid diseases. One of the most prevalent of these is infection with EBV.…”

“…Their analysis of more than 13 000 patients revealed not only that older (over 60) patients had worse 5‐ and 8‐year survival than did younger (under 40) patients, but also that survival of older patients decreased more than that of younger patients between 5 and 8 years after diagnosis. These differences in outcomes for older patients can likely be attributed in some part to an increased burden of co‐morbid disease, which could allow a tumour to metastasise more freely …”

The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

“…In particular, age has been found to play a role for the prognosis of OPC with a cut-off point of 65 years [ 37 , 45 , 46 ]. Similarly to OPC, for NPC patients age significantly impacts on survival [ 47 , 48 ].…”